Study reveals crucial details on skin-related side effects of cancer immune therapies
Investigators uncover 10 skin-related conditions linked to immune checkpoint inhibitors and identify which patients are more likely to develop them
2021-04-12
(Press-News.org) BOSTON - Immune checkpoint inhibitors, which boost the immune system's response against tumor cells, have transformed treatment for many advanced cancers, but short-term clinical trials and small observational studies have linked the medications with various side effects, most commonly involving the skin. A more comprehensive, population-level analysis now provides a thorough look at the extent of these side effects and provides insights on which patients may be more likely to experience them. The research was led by investigators at Massachusetts General Hospital (MGH) and is published in the END
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Researchers identify surface protein as a new osteosarcoma therapeutic target for antibody-drug conjugates
2021-04-12
Abstract #LB008
HOUSTON -- A preclinical study led by researchers at The University of Texas MD Anderson Cancer Center shows an antibody-drug conjugate (ADC) targeting surface protein MT1-MMP can act as a guided missile in eradicating osteosarcoma tumor cells without damaging normal tissues. This technology, using precision therapy targeting of cell-surface proteins through a Bicycle toxin conjugate (BTC), shows encouraging results for the treatment of osteosarcoma.
Findings from the study were presented today by Yifei Wang, M.D., a postdoctoral fellow of Pediatrics Research, at the virtual ...
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Blood taken from a small group of children before the COVID-19 pandemic contains memory B cells that bind SARS-CoV-2 and weakly cross-react with other coronaviruses, a new study finds, while adult blood and tissue showed few such cells. "Further study of the role of cross-reactive memory B cell populations... will be important for ongoing improvement of vaccines to SARS-CoV-2, its viral variants, and other pathogens," the authors say. As the COVID-19 pandemic has continued, children have often exhibited faster viral clearance and lower viral antigen loads than adults; whether B cell repertoires against SARS-CoV-2 (and other pathogens) differ between children and ...
Bottom-up is the way forward for nitrogen reduction at institutions
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WOODS HOLE, Mass. -- Nitrogen is an element basic for life -- plants need it, animals need it, it's in our DNA -- but when there's too much nitrogen in the environment, things can go haywire. On Cape Cod, excess nitrogen in estuaries and salt marshes can lead to algal blooms, fish kills, and degradation of the environment.
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Road salts and other human sources are threatening world's freshwater supplies
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When winter storms threaten to make travel dangerous, people often turn to salt, spreading it liberally over highways, streets and sidewalks to melt snow and ice. Road salt is an important tool for safety, because many thousands of people die or are injured every year due to weather related accidents. But a new study led by Sujay Kaushal of the University of Maryland warns that introducing salt into the environment--whether it's for de-icing roads, fertilizing farmland or other purposes--releases toxic chemical cocktails that create a serious and growing global threat to our freshwater supply and human health.
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2021-04-12
Researchers have genetically engineered a probiotic yeast to produce beta-carotene in the guts of laboratory mice. The advance demonstrates the utility of work the researchers have done to detail how a suite of genetic engineering tools can be used to modify the yeast.
"There are clear advantages to being able to engineer probiotics so that they produce the desired molecules right where they are needed," says Nathan Crook, corresponding author of the study and an assistant professor of chemical and biomolecular engineering at North Carolina State University. "You're not just delivering drugs or nutrients; you are effectively manufacturing the drugs or nutrients on site."
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Spanking may affect the brain development of a child
2021-04-12
Spanking may affect a child's brain development in similar ways to more severe forms of violence, according to a new study led by Harvard researchers.
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UConn researchers find bubbles speed up energy transfer
2021-04-12
Energy flows through a system of atoms or molecules by a series of processes such as transfers, emissions, or decay. You can visualize some of these details like passing a ball (the energy) to someone else (another particle), except the pass happens quicker than the blink of an eye, so fast that the details about the exchange are not well understood. Imagine the same exchange happening in a busy room, with others bumping into you and generally complicating and slowing the pass. Then, imagine how much faster the exchange would be if everyone stepped back and created a safe bubble for the pass to happen unhindered.
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Antidepressant use in pregnancy tied to affective disorders in offspring; no causal link
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Binge-eating is not caused by stress-induced impulsivity
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Stress alters brain activity in self-inhibition areas yet doesn't trigger binge-eating, according to new research published in JNeurosci.
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Stress does not lead to loss of self-control in eating disorders
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A unique residential study has concluded that, contrary to perceived wisdom, people with eating disorders do not lose self-control - leading to binge-eating - in response to stress. The findings of the Cambridge-led research are published today in the Journal of Neuroscience.
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[Press-News.org] Study reveals crucial details on skin-related side effects of cancer immune therapiesInvestigators uncover 10 skin-related conditions linked to immune checkpoint inhibitors and identify which patients are more likely to develop them