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Testing tool can quickly distinguish between viral and bacterial infections

The approach could help clinicians know when to correctly prescribe antibiotics

2021-05-04
(Press-News.org) DURHAM, N.C. - When patients complain of coughing, runny nose, sneezing and fever, doctors are often stumped because they have no fundamental tool to identify the source of the respiratory symptoms and guide appropriate treatments.

That tool might finally be on its way. In a study proving feasibility, researchers at Duke Health showed that their testing technology can accurately distinguish between a viral and a bacterial infection for respiratory illness - a critical difference that determines whether antibiotics are warranted. And, importantly, the test provided results in under an hour.

"This is exciting progress," said study lead Ephraim Tsalik, associate professor in the departments of Medicine and Molecular Genetics and Microbiology at Duke University School of Medicine.

"We've been working on this for over a decade," Tsalik said. "We knew in 2016 that our test worked in the research setting, but it's always been our goal to have a test that could produce results rapidly, while patients are at their doctor's office. It's important that the distinction can be made quickly to ensure that antibiotics are not inappropriately prescribed."

Tsalik and colleagues published results of their study in the journal Critical Care Medicine, which confirm the test's accuracy with results available in under an hour.

The researchers have developed a gene expression method that diverges from current diagnostic strategies, which focus on identifying specific pathogens. The current tests are time-consuming and can only identify a pathogen if it's specifically targeted by the test in the first place.

Host gene expression, however, looks for a distinct immune signal that is unique to the type of infection the body is fighting. The immune system activates one set of genes when fighting bacterial infections and a different set of genes in response to a viral infection. After the team discovered these gene expression signatures for bacterial and viral infection, they collaborated with BioFire Diagnostics, a company that specializes in molecular diagnostics, to develop this first-of-its kind test.

In a multisite study of more than 600 patients presenting to hospital emergency departments with respiratory infections, the tests identified bacterial infections with 80% accuracy and viral infections with nearly 87% accuracy. The current standard tests have about 69-percent accuracy. Tests provided results in less than an hour, and their accuracy was confirmed retrospectively using two different methods.

"Acute respiratory illness is the most common reason that people visit a health care provider when feeling sick," Tsalik said. "Patients with these symptoms are inappropriately treated with antibiotics far too often due to challenges in discriminating the cause of illness, fueling antibiotic resistance. Our study shows that a rapid test to distinguish between these two sources of illness is possible and could improve clinical care."

Tsalik said additional studies are underway to validate this approach in additional groups of patients. The researchers are also working to adapt the technology to produce more specific information, including whether the virus causing illness is influenza or SARS-CoV-2.

INFORMATION:

In addition to Tsalik, study authors include Ricardo Henao, Jesse L. Montgomery, Jeff W. Nawrocki, Mert Aydin, Emily C. Lydon, Emily R. Ko, Elizabeth Petzold, Bradly P. Nicholson, Charles B. Cairns, Seth W. Glickman, Eugenia Quackenbush, Stephen F. Kingsmore, Anja K. Jaehne, Emanuel P. Rivers, Raymond J. Langley, Vance G. Fowler, Micah T. McClain, Robert J. Crisp, Geoffrey S. Ginsburg, Thomas W. Burke, Andrew C. Hemmert, Christopher W. Woods and The Antibacterial Resistance Leadership Group.

The study received support in part from the National Institute of Allergy and Infectious Diseases of the National Institute of Health (U01AI066569, UM1AI104681) and the U.S. DARPA (N66001-09-C2082).

Among other conflicts listed in the study manuscript, Tsalik, Henao, McClain, Ginsburg, Burke and Woods have filed for patents pertaining to the gene signatures; Tsalik, Ginsburg and Woods are co-founders of Predigen, Inc., to develop the technology.



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[Press-News.org] Testing tool can quickly distinguish between viral and bacterial infections
The approach could help clinicians know when to correctly prescribe antibiotics