PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

When small epigenomic signals matter

A new study has compared broad-spectrum epigenetic signals in cell lines of humans and other primates and identified some specific regulatory elements in humans that are directly involved in neuronal functions in the brain

2021-06-16
(Press-News.org) Although each organism has a unique genome, a single gene sequence, each individual has many epigenomes. An epigenome consists of chemical compounds and proteins that can bind to DNA and regulate gene action, either by activating or deactivating them or producing organ- or tissue-specific proteins. As it is a highly dynamic material, it can provide a large amount of information to shed light on the evolution of the various tissues and organs that make up the body.

Now, a team from the Institute of Evolutionary Biology (IBE), a joint centre of the Spanish National Research Council (CSIC) and Pompeu Fabra University, has carried out the largest study to date on the regulatory elements in the genome of primates. The exhaustive analysis conducted by the research team led by Tomas Marquès-Bonet, principal investigator of the Comparative Genomics research group at the IBE, has analysed a wide spectrum of signals regulating genes in the great apes and in humans, including weak activity signals that have been overlooked in previous studies. The study, co-led by the researcher David Juan of the IBE, has revealed that in humans, the weakest regulatory signals, that are not usually studied, play an important role in the regulation of genes linked to brain. The research opens the door to deciphering the impact that these signals may have on the evolution of humans and other primates.

The research lab has carried out the largest study to date on the regulatory elements in the genome of primates.

The research team used high resolution to analyse epigenomic signals in cell lines of great apes and humans. In particular, the research provides new epigenomic data for four species of great apes and other primates: chimpanzees, gorillas, orangutans and macaques.

"In the study we used lymphoblastoid cell lines from humans and other primates because they provide a solid foundation as a model. Then we compared epigenomic signals between the different species, including the weakest activity signals in our analysis", comments Raquel García, a PhD with the Comparative Genomics group of the IBE and first author of the article.

"When we focused on detecting those specific characteristics of humans in the weakest epigenomic signals, we saw that they are related to brain functions", explains Paula Esteller, a PhD student with Marquès-Bonet's group and study co-author. "This opens the door to studying the role of weak epigenomic signals in depth, as they may play an important role in various organs of humans and of other primates".

The study includes weak epigenomic signals, usually ignored, and it has been seen that in humans they are related to brain functions.

The study, carried out using lymphoblastoid cells, which are easily accessible and easy to culture, suggests that this model could provide information on other more inaccessible tissues, such as the brain. The research could help understand how primates' cells are regulated and which of these mechanisms have been conserved over the course of evolution. The study also provides a comprehensive resource of genomic and epigenomic data on primates that are made available to the entire scientific community.

INFORMATION:

Reference article:

García-Pérez, R. et.al. Nature Communications, 2021; Epigenomic profiling of primate lymphoblastoid cell lines reveals the evolutionary patterns of epigenetic activities in gene regulatory architectures; DOI: https://doi.org/10.1038/s41467-021-23397-1.



ELSE PRESS RELEASES FROM THIS DATE:

Sticky transparent wall coating can capture aerosols and droplets from the air

2021-06-16
By repurposing common ingredients in hair conditioner, scientists have designed an inexpensive, transparent coating that can turn surfaces like windows and ceilings into glue pads to trap airborne aerosol droplets. This new strategy is described June 16 in the journal Chem. "Facing a pandemic, we need to proactively leverage all of the different layers of defense mechanisms, including the physical barriers," says corresponding author Jiaxing Huang, a professor of materials science and engineering at Northwestern University. "After all, these viruses must travel through physical space before reaching and eventually infecting people." The ...

When testing Einstein's theory of general relativity, small modeling errors add up fast

2021-06-16
Small modeling errors may accumulate faster than previously expected when physicists combine multiple gravitational wave events (such as colliding black holes) to test Albert Einstein's theory of general relativity, suggest researchers at the University of Birmingham in the United Kingdom. The findings, published June 16 in the journal iScience, suggest that catalogs with as few as 10 to 30 events with a signal-to-background noise ratio of 20 (which is typical for events used in this type of test) could provide misleading deviations from general relativity, erroneously pointing to new physics where none exists. Because this is close to the size of current catalogs used to assess Einstein's ...

Researchers find human infant brains, bodies are active during new sleep stage

2021-06-16
Human babies do even more than we thought while sleeping. A new study from University of Iowa researchers provides further insights into the coordination that takes place between infants' brains and bodies as they sleep. The Iowa researchers have for years studied infants' twitching movements during REM sleep and how those twitches contribute to babies' ability to coordinate their bodily movements. In this study, the scientists report that beginning around three months of age, infants see a pronounced increase in twitching during a second major stage of sleep, called quiet sleep. "This was completely surprising and, for all we know, ...

Mystery solved: Dust cloud led to Betelgeuse's 'Great Dimming'

2021-06-16
When Betelgeuse, a bright orange star in the constellation of Orion, lost more than two-thirds of its brightness in late 2019 and early 2020, astronomers were puzzled. What could cause such an abrupt dimming? Now, in a new paper published Wednesday in Nature, an international team of astronomers reveal two never-before-seen images of the mysterious darkening --and an explanation. The dimming was caused by a dusty veil shading the star, which resulted from a drop in temperature on Betelgeuse's stellar surface. Led by Miguel Montargès at the Observatoire de Paris, the new images were taken in January and March of 2020 using the European Southern Observatory's Very Large Telescope. Combined with images previously taken in ...

Correlated errors in quantum computers emphasize need for design changes

Correlated errors in quantum computers emphasize need for design changes
2021-06-16
EMBARGOED UNTIL 11 A.M. ET WEDNESDAY, JUNE 16, 2021 MADISON, Wis. -- Quantum computers could outperform classical computers at many tasks, but only if the errors that are an inevitable part of computational tasks are isolated rather than widespread events. Now, researchers at the University of Wisconsin-Madison have found evidence that errors are correlated across an entire superconducting quantum computing chip -- highlighting a problem that must be acknowledged and addressed in the quest for fault-tolerant quantum computers. The researchers report their findings in a study published June 16 in the journal Nature, Importantly, their work also points to mitigation strategies. "I think people have been approaching the problem of error correction in an overly optimistic ...

Researchers translate a bird's brain activity into song

2021-06-16
It is possible to re-create a bird's song by reading only its brain activity, shows a first proof-of-concept study from the University of California San Diego. The researchers were able to reproduce the songbird's complex vocalizations down to the pitch, volume and timbre of the original. Published June 16 in Current Biology, the study lays the foundation for building vocal prostheses for individuals who have lost the ability to speak. "The current state of the art in communication prosthetics is implantable devices that allow you to generate textual output, writing up to 20 words per minute," said senior author Timothy Gentner, a professor of psychology and neurobiology ...

Mystery of Betelgeuse's dip in brightness solved

Mystery of Betelgeuses dip in brightness solved
2021-06-16
When Betelgeuse, a bright orange star in the constellation of Orion, became visibly darker in late 2019 and early 2020, the astronomy community was puzzled. A team of astronomers have now published new images of the star's surface, taken using the European Southern Observatory's Very Large Telescope (ESO's VLT), that clearly show how its brightness changed. The new research reveals that the star was partially concealed by a cloud of dust, a discovery that solves the mystery of the "Great Dimming" of Betelgeuse. Betelgeuse's dip in brightness -- a change noticeable even to the ...

Association of cannabis use during adolescence with neurodevelopment

2021-06-16
What The Study Did: Researchers examined to what extent cannabis use is associated with thickness in brain areas measured by magnetic resonance imaging in a study of adolescents. Authors: Matthew D. Albaugh, Ph.D., of the University of Vermont Larner College of Medicine in Burlington, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (10.1001/jamapsychiatry.2021.1258) Editor's Note: The article includes conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support. INFORMATION: Media advisory: The ...

Survival among adults with early-onset colorectal cancer

2021-06-16
What The Study Did: Survival among people with early-onset (diagnosed before age 50) colorectal cancer compared with later-onset colorectal cancer (diagnosed at ages 51 through 55) was compared using data from the National Cancer Database. Authors: Charles S. Fuchs, M.D., M.P.H., of the Yale School of Public Health in New Haven, Connecticut, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2021.12539) Editor's Note: The article includes conflicts of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and ...

Incidence of SARS-CoV-2 Infection in Health Care Workers After 1st Dose of Moderna Vaccine

2021-06-16
What The Study Did: This study demonstrated an association between receiving the mRNA-1273 (Moderna) vaccine and a reduction in SARS-CoV-2 infection in health care workers beginning eight days after the first dose. Authors: Michael E. Charness, M.D., of the VA Boston Healthcare System in West Roxbury, Massachusetts, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2021.16416) Editor's Note: The article includes conflict of interest ...

LAST 30 PRESS RELEASES:

New way to find “aged” cells marks fresh approach for research into ageing

From blood sugar to brain relief: GLP-1 therapy slashes migraine frequency

Variability in heart rate during sleep may reveal early signs of stroke, depression or cognitive dysfunction, new study shows

New method to study catalysts could lead to better batteries

Current Molecular Pharmacology impact factor rises to 2.9, achieving Q2 ranking in the Pharmacology & Pharmacy category in 2024 JCR

More time with loved ones for cancer patients spared radiation treatment

New methods speed diagnosis of rare genetic disease

Genetics of cardiomyopathy risk in cancer survivors differ by age of onset

Autism inpatient collection releases genetic, phenotypic data for more than 1,500 children with autism

Targeting fusion protein’s role in childhood leukemia produces striking results

Clear understanding of social connections propels strivers up the social ladder

New research reveals why acute and chronic pain are so different – and what might make pain last

Stable cooling fostered life, rapid warming brought death: scientists use high-resolution fusuline data reveal evolutionary responses to cooling and warming

New research casts doubt on ancient drying of northern Africa’s climate

Study identifies umbilical cord blood biomarkers of early onset sepsis in preterm newborns

AI development: seeking consistency in logical structures

Want better sleep for your tween? Start with their screens

Cancer burden in neighborhoods with greater racial diversity and environmental burden

Alzheimer disease in breast cancer survivors

New method revolutionizes beta-blocker production process

Mechanism behind life-threatening cancer drug side-effect revealed

Weighted vests might help older adults meet weight loss goals, but solution for corresponding bone loss still elusive

Scientists find new way to predict how bowel cancer drugs will stop working – paving the way for smarter treatments

Breast cancer patients’ microbiome may hold key to avoiding damaging heart side-effects of cancer therapies

Exercise-induced protein revives aging muscles and bones

American College of Cardiology issues guidance on weight management drugs

Understanding the effect of bedding on thermal insulation during sleep

Cosmic signal from the very early universe will help astronomers detect the first stars

With AI, researchers find increasing immune evasion in H5N1

Study finds hidden effects of wildfires on water systems

[Press-News.org] When small epigenomic signals matter
A new study has compared broad-spectrum epigenetic signals in cell lines of humans and other primates and identified some specific regulatory elements in humans that are directly involved in neuronal functions in the brain