New machine learning methods could improve environmental predictions

In a cancer that has not seen new targeted therapies for over 20 years, MUSC Hollings Cancer Center researcher and oncologist Nancy Klauber-DeMore, M.D., is pioneering new discoveries. Using a combination of personal passion and expertise, Klauber-DeMore shifted her knowledge of the pro-angiogenic protein SFRP2 in breast cancer to address the lack of treatment options for patients with aggressive metastatic osteosarcoma. The results of the combination treatment with SFRP2 and PD-1 antibodies in a preclinical model were published in Cancers. Osteosarcoma expert William Tap, M.D., chief of the Sarcoma Medical Oncology Service at Memorial Sloan Kettering ...

Changes in climate resulting from carbon dioxide (CO2) emissions into the Earth's atmosphere are not equal to the climate changes from deliberate CO2 removals--and assuming such a balance could lead to different climate outcomes that may skew climate targets, according to new Simon Fraser University-led research. "Because of the complexity of the Earth's system, things are not as simple as "one ton of CO2 in, equals one ton of CO2 out," says Kirsten Zickfeld, a distinguished professor of climate science in SFU's Department of Geography, and lead author of a new paper published ...

The shift to home working brought about by the pandemic could cost the UK economy up to £32bn a year in lost personal income tax. Highly paid workers who live abroad but work in the UK will pay their income tax in their country of residence, rather than to HMRC - which researchers say could cost billions each year. This new mobility of the workforce can also affect where corporate income tax is paid and value created, as well as VAT and where goods and services are purchased. Professor Rita de la Feria, Chair in Tax Law in the University of Leeds' School of Law, co-led the new research with Dr Giorgia Maffini, Tax Policy expert, at PWC, ...

Legend has it that Marie Antoinette's hair turned gray overnight just before her beheading in 1791. Though the legend is inaccurate--hair that has already grown out of the follicle does not change color--a new study from researchers at Columbia University Vagelos College of Physicians and Surgeons is the first to offer quantitative evidence linking psychological stress to graying hair in people. And while it may seem intuitive that stress can accelerate graying, the researchers were surprised to discover that hair color can be restored when stress is eliminated, a finding that contrasts with a recent study in mice that suggested that stressed-induced gray hairs are permanent. The ...

WOODS HOLE, Mass. -- It's cold in the depths of the world's oceans; most of the seafloor is at a chilly 4°C. Not so the seafloor of Guaymas Basin in the Gulf of California. Here, tectonic plates drift apart and heat from Earth's interior can rise up -- so far up that it bakes large areas of the seafloor sediments, turning buried organic matter into methane and other energy-rich compounds. What kinds of organisms thrive in this oceanic hotspot? In two new studies, MBL Assistant Scientist END ...

Looking for better ways to treat patients with esophageal cancer, University of Colorado Cancer Center member Martin McCarter, MD, is investigating whether a new treatment sequence will result in better outcomes. As they await the results of a group of clinical trials -- including one at the CU Cancer Center -- McCarter and other University of Colorado researchers (led by surgery resident Bobby Torphy, MD, PhD) looked at data from the National Cancer Database to see if they could identify other patients who have undergone the new sequence, and what the outcomes for those patients were. The group published a paper in the Annals of Surgical Oncology in April ...

Rainfall associated with the Intertropical Convergence Zone (ITCZ), the belt of converging trade winds and rising air that encircles the Earth near the Equator, affects the food and water security of approximately 1 billion people worldwide. They include about 11% of the Brazilian population, concentrated in four states of the Northeast region - Rio Grande do Norte, Ceará, Piauí, and Maranhão. Large swathes of these states have a semi-arid climate, and about half of all their annual rainfall occurs in only two months (March and April), when the tropical rain belt reaches its southernmost position, over the north of the Northeast region. During the rest of the year, the tropical ...

(SACRAMENTO, Calif.) -- The secret to healthier skin and joints may reside in gut microorganisms. A study led by UC Davis Health researchers has found that a diet rich in sugar and fat leads to an imbalance in the gut's microbial culture and may contribute to inflammatory skin diseases such as psoriasis. ...

New research published in the Journal of Medicinal Food suggests eating prunes each day can improve risk factors for cardiovascular disease (CVD) including raising antioxidant capacity and reducing inflammation among healthy, postmenopausal women. Cardiovascular disease is the number one cause of death worldwide posing a significant public health challenge. The research led by San Diego State University reveals that prunes can positively affect heart disease risk. "When you look at our prior research and the research of others combined with this new data, you'll see consistent ...

"Workforce issues are the most significant challenges facing the long-term care industry," states the opening editorial of a new special issue of The Gerontologist titled " END ...