Comparing spending on common generic drugs by Medicare vs Costco members

Melbourne researchers have identified a way to improve the immune response in the face of severe viral infections. It is widely known that severe viral infections and cancer cause impairments to the immune system, including to T cells, a process called immune 'exhaustion'. Overcoming immune exhaustion is a major goal for the development of new therapies for cancer or severe viral infections. A team from the Peter Doherty Institute of Infection and Immunity (Doherty Institute) led by University of Melbourne's Dr Sarah Gabriel, Dr Daniel Utzschneider and Professor Axel Kallies has been able to identify why immune exhaustion occurs and how this may be overcome. The team had previously identified that while some T cells ...

Most human cells are able to repair damage by dividing at wounds. But mature nerve cells (neurons) in our brain are different. If they attempt division, they will likely die - and this is what happens during brain injury, or in conditions such as Alzheimer's Disease (AD). Now new research led by the University of Plymouth has uncovered a pathway that has shed new light on how these divisions may be triggered. The research, published today in Cell Reports, has focused on intracellular structures called microtubules - which are found in most animal cells, and can be damaged by a build-up of a protein called Tau in the brain during AD. The study was conducted in fruit flies, with comparison to postmortem brain samples ...

Can you remember the smell of flowers in your grandmother's garden or the tune your grandpa always used to whistle? Some childhood memories are seemingly engrained into your brain. In fact, there are critical periods in which the brain learns and saves profound cognitive routines and memories. The structure responsible for saving them is called the perineuronal net. This extracellular structure envelops certain neurons, thereby stabilizes existing connections - the synapses - between them and prevents new ones from forming. But what if we could remove the perineuronal net and restore the adaptability of a young brain? The neuroscientist Sandra Siegert and her research group at IST Austria now ...

Dinosaurs were generally huge, but a new study of the unusual alvarezsaurs show that they reduced in size about 100 million years ago when they became specialised ant-eaters. The new work is led by Zichuan Qin, a PhD student at the University of Bristol and Institute of Vertebrate Paleontology and Paleoanthropology in Beijing. He measured body sizes of dozens of specimens and showed that they ranged in size from 10-70 kg, the size of a large turkey to a small ostrich, for most of their existence and then plummeted rapidly to chicken-sized animals at the same time as they adopted a remarkable ...

An international team of scientists has used high-powered X-rays at the European Synchrotron, the ESRF, to show how an extinct South African 200-million-year-old dinosaur, Heterodontosaurus tucki, breathed. The study is published in eLife on 6 July 2021. In 2016, scientists from the Evolutionary Studies Institute at the University of the Witwatersrand in Johannesburg, South Africa, came to the ESRF, the European Synchrotron in Grenoble, France, the brightest synchrotron light source, for an exceptional study: to scan the complete skeleton of a small, 200-million-year-old plant-eating dinosaur. The dinosaur specimen is the most complete fossil ever discovered of a species known as Heterodontosaurus tucki. The fossil was found in ...

At the end of life, people may have to rely on others for help with showering, dressing and going to the toilet. This loss of privacy and independence can be confronting and difficult. Now Australian occupational therapy (OT) researchers have interviewed 18 people receiving palliative care about how they feel about losing independence with self-care, specifically their intimate hygiene, as function declines with disease progression. The study aims to raise awareness of how to provide better care for people at the end of life. Lead researcher Dr Deidre Morgan, a Flinders University occupational ...

A research team at POSTECH has uncovered a promising new zeolite, anticipated to be a turning point for the oil refining and petrochemical industries. This research was recently published in the scientific journal Science on July 2, 2021. The team of researchers led by Suk Bong Hong, a professor in the Division of Environmental Science and Engineering at POSTECH, synthesized two thermally stable three-dimensional (3D) large-pore (12-ring)1 zeolites - PST-32 (POSTECH No. 32) and PST-2, the hypothetical SBS/SBT intergrowth structure2 - by using the "multiple inorganic cation" and the "charge density mismatch" synthetic strategies, respectively. The research team identified their structures by using both powder X-ray diffraction ...

New research in BMC Cancer has shown myelosuppressive chemotherapy destabilises gut microbiome in patients with solid organ cancers. The study from SAHMRI and Flinders University assessed the gut health of men and women who underwent conventional chemotherapy on cancers, such as breast and lung cancer, without exposure to antibiotics. "We know that myelosuppressive chemotherapy reduces white blood cell count significantly during the first seven to 10 days of treatment, making the body more vulnerable to infection," says lead author Dr Lito Papanicolas, an infectious diseases expert and clinical microbiologist. "In this study we focused on how much the individual's microbiome changed over this period, when the ...

Scientists at UC San Francisco have shown that gene-edited cellular therapeutics can be used to successfully treat cardiovascular and pulmonary diseases, potentially paving the way for developing less expensive cellular therapies to treat diseases for which there are currently few viable options. The study, in mice, is the first in the emerging field of regenerative cell therapy to show that products from specially engineered induced pluripotent stem cells called "HIP" cells can successfully be employed to treat major diseases while evading the ...

A 15-year reciprocal transplant study on Guam's native cycad tree, Cycas micronesica, by the Plant Physiology Laboratory at the University of Guam's Western Pacific Tropical Research Center has revealed that acute adaptation to local soil conditions occurs among the tree population and is important in the survival rate of transplanted cycads. The results show that 70% to 100% of cycads that were transplanted in local conditions survived versus less than 10% that were transplanted in foreign conditions. The article describing the study has been published in the peer-reviewed journal Diversity (doi: 10.3390/d13060237). Transplantation ...