Ludwig Cancer Research study reveals even transient chromosomal errors can initiate cancer
JULY 15, 2021, NEW YORK - A Ludwig Cancer Research study has found that inducing random chromosome instability (CIN) events in mice for as little as one week is enough to trigger harmful chromosomal patterns in cells that spur the formation of tumors.
"We show that you don't need chronic, lifelong chromosomal mistakes to produce tumorigenesis at a quite respectable frequency," said Don Cleveland, Member of the Ludwig Institute for Cancer Research, San Diego, who led the study with Floris Foijer of the University of Groningen, in The Netherlands. "A very transient exposure would likely be sufficient to drive a very substantial increase in tumorigenesis."
The finding, detailed this week in the journal END
"We show that you don't need chronic, lifelong chromosomal mistakes to produce tumorigenesis at a quite respectable frequency," said Don Cleveland, Member of the Ludwig Institute for Cancer Research, San Diego, who led the study with Floris Foijer of the University of Groningen, in The Netherlands. "A very transient exposure would likely be sufficient to drive a very substantial increase in tumorigenesis."
The finding, detailed this week in the journal END