Ludwig Cancer Research study reveals even transient chromosomal errors can initiate cancer

Washington, DC / New Delhi, India - Researchers at CDDEP recently published 'Improving vaccination coverage and timeliness through periodic intensification of routine immunization: evidence from Mission Indradhanush' where they evaluated the performance of India's Mission Indradhanush (MI) child vaccination campaign -- a periodic intensification of the routine immunization program. Each year, 1.2 million Indian children die, accounting for a fifth of global under-5 deaths. Over 400,000 of these deaths are from vaccine-preventable diseases. An estimated 38% of Indian children under the age of two years were not-fully-immunized in 2016. Additionally, vaccinated children received 23%-35% of the doses of polio, diphtheria-pertussis-tetanus ...

Main points Strong evidence that patients with pre-existent mental disorders are twice as likely to die or be hospitalised after SARS-CoV-2 infection Psychotic and mood disorders are linked with COVID-19-associated mortality, as are exposure to antipsychotic and anxiolytic treatments. Patients with substance use disorders are at increased risk of hospitalisation. In the largest systematic review and meta-analysis to date on COVID-19 outcomes in individuals with psychiatric disorders, the odds of dying or being hospitalized following COVID-19 ...

The team's findings, with important implications for ocean biogeochemistry and climate science, have been published by Nature Communications in a paper by Associate Professor Mark Holzer from UNSW Science's School of Mathematics & Statistics, with co-authors Tim DeVries (UCSB) and Casimir de Lavergne (LOCEAN). "The deep North Pacific is a vast reservoir of remineralized nutrients and respired carbon that have accumulated over centuries," says A/Prof. Holzer. "When these deep waters are returned to the surface, their nutrients support biological production and their dissolved CO2 can be released into the atmosphere. As such, the deep Pacific plays a key ...

Central nervous system (CNS) diseases such as Alzheimer's disease (AD) manifest early at the microscopic (i.e. cellular) level, deep in the brain. Yet, optical microscopes that can see cells in the living brain are superficial or invasive. Whole brain imaging techniques such as magnetic resonance imaging are deep and non-invasive, but lack cellular resolution. In a new paper published in Light Science & Application, a team of scientists, led by Professor Vivek J. Srinivasan from the Departments of Ophthalmology and Radiology and Tech4Health Institute, ...

Shizuoka, Japan - At Shikine Island, Japan, kelp forests and abalone fisheries were once common, but over the last twenty years they have disappeared. Now, researchers from Japan have discovered that these temperate coastal marine ecosystems are becoming more "simple", losing biodiversity, complexity and their aesthetic values. In a study published this month, researchers from the University of Tsukuba and international collaborators explored how the combined effects of ocean warming and acidification are changing temperate coastal marine ecosystems. Tropical coastal seas are synonymous with coral reefs. As ocean temperatures cool toward the poles, corals give way to kelp as the main habitat-forming species. The shift from coral to kelp can clearly be seen along the 2000 km ...

The laws of quantum physics rule the microcosm. They determine, for example, how easily electrons move through a crystal and thus whether the material is a metal, a semiconductor or an insulator. Quantum physics may lead to exotic properties in certain materials: In so-called topological insulators, only the electrons that can occupy some specific quantum states are free to move like massless particles on the surface, while this mobility is completely absent for electrons in the bulk. What's more, the conduction electrons in the "skin" of the material are necessarily spin polarized, and form robust, metallic surface states that could be utilized as channels in which to drive pure spin currents on femtosecond ...

An international research team led by YAO Zhonghua from the Institute of Geology and Geophysics of the Chinese Academy of Sciences (IGGCAS) has explained the cause of Jupiter's X-ray aurorae, a mystery that has puzzled scientists for 40 years. The findings were published in Science Advances on July 9. It is the first time planetary researchers have described the entire causality chain for Jupiter's X-ray auroral flares. The mechanism in producing X-ray auroral flares at Jupiter may have potential applications in X-ray astronomy. The X-ray auroral spectra tell us these aurorae are produced by heavy ions with energies in the ...

From the vocal cords that produce our voice, to our heartbeat, our body's cells are constantly subjected to mechanical forces that steadily change their response to these stimuli, regulating vital processes, in healthy individuals and in diseases such as cancer alike. Nevertheless, despite their importance, we remain largely ignorant of how cells sense and respond to these forces. Now, an international team co-led by the researcher Pere Roca-Cusachs, from the Institute for Bioengineering of Catalonia (IBEC), and Isaac Almendros, a researcher at the Respiratory Diseases Networking Biomedical Research Centre (CIBERES) and IDIBAPS, both professors at the Faculty of Medicine and Health Sciences of the University of Barcelona (UB), has proved that what determines mechanical ...

The article represents the transmission electron microscopy (TEM) and flow cytometry study of A-549 (human lung carcinoma) cellular uptake of Pr3+:LaF3 nanoparticles. The Pr3+:LaF3 nanoparticles are promising platforms for cell nano-sensors. The objective of the work was to study the influence of nanoparticle morphology (nanoplates and nanospheres) on cytotoxicity and the dynamic of cellular uptake. In the flow cytometry method, the cells go through a small tube (as a flow) and are irradiated by a laser. Cells scatter the laser light, and this scattering ...

Measurements of biomechanical properties inside living cells require minimally invasive methods. Optical tweezers are particularly attractive as a tool. It uses the momentum of light to trap and manipulate micro- or nanoscale particles. A team of researchers led by Prof. Dr. Cornelia Denz from the University of Münster (Germany) has now developed a simplified method to perform the necessary calibration of the optical tweezers in the system under investigation. Scientists from the University of Pavia in Italy were also involved. The results of the study have been published in the journal Scientific Reports. The calibration ensures that measurements of different samples and with different devices are comparable. ...