Of lives and life years: 1918 influenza vs COVID-19

Next time, vaccination may be too little, too late

2021-07-19

(Press-News.org) From the onset of the COVID-19 pandemic there have been countless comparisons to the 1918 influenza pandemic in terms of overall medical impact. Many of the comparisons addressed overall cases which, given the lack of a confirmatory lab test in 1918 and no meaningful case definitions for both pandemics, make such comparisons patently invalid. Overall mortality comparisons, although methodologically flawed as well, do offer a reasonably comparative outcome measure and offers a greater degree of validity. This measure is further enhanced when adjusted for population and average life years lost (see accompanying table for mortality comparisons presented 3 ways). The resulting value(s) can also be used to assess and better quantify the cumulative health impacts of our interventions and give a more objective base for our decision-making. A concluding observation is presented on the impact of a rapidly developed vaccine on a 1918 type event.

INFORMATION:

[Attachments] See images for this press release:

ELSE PRESS RELEASES FROM THIS DATE:

Novel autoantibody adds fuel to COVID-19 'firestorm' of inflammation, blood clots

2021-07-19

Researchers at Michigan Medicine have discovered yet another functional autoantibody in COVID-19 patients that contributes to the disease's development and the "firestorm" of blood clots and inflammation it induces. A growing body of studies suggests COVID-19 emulates many aspects of systemic autoimmune disorders, including the release of a flurry of overactive immune cells that produce toxic webs of proteins and DNA called neutrophil extracellular traps, or NETs. For this study, the team analyzed serum from over 300 hospitalized COVID patients, searching for a novel autoantibody that shields the toxic NETs from being destroyed and produces a lasting ...

New study examines commuter characteristics and traffic pollution exposure among commuters

2021-07-19

The link between on-road traffic and air pollution is well-known, as are the negative health impacts of pollution exposure. However, the many factors that may influence commuters' exposure to pollutants - such as frequency, time, and duration of commute - and the overall impact of commuting remains a matter of on-going scientific discovery. Dr. Jenna Krall, assistant professor at the George Mason University College of Health and Human Services, is using statistical methods to better understand exposure to air pollution. Krall studies how commuting patterns impact exposure to fine particulate matter ...

A new, inexpensive way to heal chronic wounds

2021-07-19

EAST LANSING, Mich. - Tens of millions of patients around the world suffer from persistent and potentially life-threatening wounds. These chronic wounds, which are also a leading cause of amputation, have treatments, but the cost of existing wound dressings can prevent them from reaching people in need. Now, a Michigan State University researcher is leading an international team of scientists to develop a low-cost, practical biopolymer dressing that helps heal these wounds. "The existing efficient technologies are far too expensive for most health care systems, ...

New high-tech portal launched to speed hearing loss innovations

2021-07-19

Researchers at the University of Maryland School of Medicine (UMSOM) launched a new online tool that could more quickly advance medical discoveries to reverse progressive hearing loss. The tool enables easy access to genetic and other molecular data from hundreds of technical research studies involving hearing function and the ear. The research portal called gene Expression Analysis Resource (gEAR) was unveiled in a study last month in Nature Methods. It is operated by a group of physician-scientists at the UMSOM Institute for Genome Sciences (IGS) in collaboration with their colleagues at other institutions. The portal allows researchers to rapidly access data and provides easily interpreted visualizations of datasets. Scientists can also input ...

Curtin study challenges recommended wait time between pregnancies

2021-07-19

New Curtin University-led research has called into question existing health advice that mothers wait a minimum of two years after giving birth to become pregnant again, in order to reduce the risk of adverse pregnancy outcomes, such as preterm and small-for-gestational age births. The research found that a World Health Organization (WHO) recommendation to wait at least 24 months to conceive after a previous birth may be unnecessarily long for mothers in high-income countries such as Australia, Finland, Norway and the United States. Lead researcher ...

How cells control mitochondria

2021-07-19

Errors in the metabolic processes of mitochondria are responsible for a variety of diseases such as Parkinson's and Alzheimer's. Scientists needed to find out just how the necessary building blocks are imported into the complex biochemical apparatus of these cell areas. The TOM complex (translocase of the outer mitochondrial membrane) is considered the gateway to the mitochondrion, the proverbial powerhouse of the cell. The working group headed by Professor Chris Meisinger at the Institute of Biochemistry and Molecular Biology at the University of Freiburg has now demonstrated - in human cells - how signaling molecules control this gate. A signaling protein called DYRK1A modifies the molecular machinery of TOM and makes it more permeable ...

When money's tight, parents talk less to kids; could this explain the word gap?

2021-07-19

Three decades ago, child development researchers found that low-income children heard tens of millions fewer words in their homes than their more affluent peers by the time they reached kindergarten. This "word gap" was and continues to be linked to a socioeconomic disparity in academic achievement. While parenting deficiencies have long been blamed for the word gap, new research from the University of California, Berkeley, implicates the economic context in which parenting takes place -- in other words, the wealth gap. The findings, published this month in the journal Developmental Science, provide the first evidence that parents may talk less to their kids when experiencing financial scarcity. "We were interested in what happens when parents think about or experience financial scarcity ...

Sleep twitches facilitate motor cortex development in rats

2021-07-19

Electrical activity in the motor cortex of rats transforms from redundant to complex over the span of four days shortly after birth. Sleep twitches guide this metamorphosis, according to new research published in JNeurosci. Despite its name, the motor cortex doesn't control movement right off the bat. Early in development, this part of the brain is solely a sensory structure. Feedback from self-generated movements -- sleep twitches in particular -- may build representations of the body that will later orchestrate movement. To characterize this transition, Glanz et al. recorded electrical activity from the motor cortex of rat pups eight and 12 days after birth while monitoring their behavior. ...

Angry politicians make angry voters, new study finds

2021-07-19

Politicians may have good reason to turn to angry rhetoric, according to research led by political scientists from Colorado--the strategy seems to work, at least in the short term. In a new study, Carey Stapleton at the University of Colorado Boulder and Ryan Dawkins at the U.S. Air Force Academy discovered that political furor may spread easily: Ordinary citizens can start to mirror the angry emotions of the politicians they read about in the news. Such "emotional contagion" might even drive some voters who would otherwise tune out of politics to head to the polls. "Politicians want to get reelected, and anger is a powerful tool that they can use to make that happen," said Stapleton, who recently earned his PhD in political science at ...

Study may show why MS patients develop progressive disability

2021-07-19

ROCHESTER, Minn. -- Did you know multiple sclerosis (MS) means multiple scars? New research shows that the brain and spinal cord scars in people with MS may offer clues to why they developprogressive disability but those with related diseases where the immune system attacks the central nervous system do not. In a study published in Neurology, Mayo Clinic researchers and colleagues assessed if inflammation leads to permanent scarring in these three diseases: MS. Aquaporin-4 antibody positive neuromyelitis optica spectrum disorder (AQP4-NMOSD). Myelin oligodendrocyte glycoprotein antibody associated disorder (MOGAD). They also studied whether scarring may be a reason for ...

Beetles under climate stress lay larger male eggs: Wolbachia infection drives adaptive reproduction strategy in response to rising temperature and CO₂

Most patients with advanced melanoma who received pre-surgical immunotherapy remain alive and disease free four years later

Introducing BioEmu: A generative AI Model that enables high-speed and accurate prediction of protein structural ensembles

Replacing mutated microglia with healthy microglia halts progression of genetic neurological disease in mice and humans

[Press-News.org] Of lives and life years: 1918 influenza vs COVID-19
Next time, vaccination may be too little, too late

Of lives and life years: 1918 influenza vs COVID-19

ELSE PRESS RELEASES FROM THIS DATE:

LAST 30 PRESS RELEASES: