(Press-News.org) We all know how important sleep is for mental health, but a meta-analysis publishing in the journal Current Biology on March 13 found that getting good shut-eye also helps our immune systems respond to vaccination. The authors found that people who slept less than six hours per night produced significantly fewer antibodies than people who slept seven hours or more, and the deficit was equivalent to two months of antibody waning.
“Good sleep not only amplifies but may also extend the duration of protection of the vaccine,” says senior author Eve Van Cauter, professor emeritus at the University of Chicago who, along with lead author Karine Spiegel at the French National Institute of Health and Medicine, published a landmark study on the effects of sleep on vaccination in 2002.
When the COVID-19 pandemic hit, and mass-vaccination became an international priority, Spiegel and Van Cauter set out to summarize our current knowledge about the effect of sleep duration on vaccine response.
To do this, they combed the literature and then combined and re-analyzed the results of seven studies that vaccinated for viral infections (influenza and hepatitis A and B). In their analysis, the team compared the antibody response for individuals who slept a “normal” amount (7–9 hours, as per the National Sleep Foundation’s recommendation for healthy adults) with “short sleepers” who slept less than 6 hours per night. They compared the effect for men versus women and adults over the age of 65 years versus younger adults.
Overall, they found strong evidence that sleeping less than 6 hours per night reduces the immune response to vaccination. When they analyzed men and women separately, though, the result was only significant in men, and the effect of sleep duration on antibody production was much more variable in women. This difference is probably due to fluctuating sex hormone levels in women, the authors say.
“We know from immunology studies that sex hormones influence the immune system,” says Spiegel. “In women, immunity is influenced by the state of the menstrual cycle, the use of contraceptives, and by menopause and post-menopausal status, but unfortunately, none of the studies that we summarized had any data about sex hormone levels.”
The negative effect of insufficient sleep on antibody levels was also greater for adults aged 18–60 compared with people over the age of 65. This was not surprising because older adults tend to sleep less in general; going from seven hours of sleep per night to less than six hours is not as big of a change as going from eight hours to less than six per night.
Some of the studies measured sleep duration directly, either via motion-detecting wristwatches or in a sleep lab, while others relied on self-reported sleep duration. In both cases, short sleep duration was associated with lower levels of antibodies, but the effect was stronger for the studies that used objective measures of sleep, likely because people are notoriously bad at estimating the amount of sleep they have had.
Knowing that sleep duration impacts vaccination might give people some degree of control over their immunity, the authors say. “When you see the variability in protection provided by the COVID-19 vaccines—people who have pre-existing conditions are less protected, men are less protected than women, and obese people are less protected than people who don't have obesity. Those are all factors that an individual person has no control over, but you can modify your sleep,” says Van Cauter.
However, there’s a lot more to be known about sleep and vaccination, the authors say. “We need to understand the sex differences, which days around the time of vaccination are most important, and exactly how much sleep is needed so that we can give guidance to people,” says Spiegel. “We are going to be vaccinating millions and millions of people in the next few years, and this is an aspect that can help maximize protection.”
###
Current Biology, Spiegel et al. ‘Impact of sleep duration on the antibody response to vaccination: A meta-analysis’, https://www.cell.com/current-biology/fulltext/S0960-9822(23)00156-2
Current Biology (@CurrentBiology), published by Cell Press, is a bimonthly journal that features papers across all areas of biology. Current Biology strives to foster communication across fields of biology, both by publishing important findings of general interest and through highly accessible front matter for non-specialists. Visit: http://www.cell.com/current-biology. To receive Cell Press media alerts, contact press@cell.com.
END
The arrival of the new year is a prime time for Antarctic birds like the south polar skua, Antarctic petrel, and snow petrel to build nests and lay their eggs. However, from December 2021 to January 2022, researchers did not find a single skua nest on Svarthamaren, one of the regions where the birds go to raise their young. Similarly, the number of Antarctic petrel and snow petrel nests dropped to almost zero.
In these regions, climate change caused snowfall and snow accumulation to be significantly higher than in previous years. Now, a study published on March 13 in the journal Current Biology shows that these unusually strong snowstorms ...
About The Study: In this study of 398,000 adult outpatients with COVID-19, the absolute risk of venous thromboembolism (VTE) was low. Several patient-level factors were associated with higher VTE risk; these findings may help identify subsets of patients with COVID-19 who may benefit from more intensive surveillance or VTE preventive strategies.
Authors: Margaret C. Fang, M.D., M.P.H., of the University of California, San Francisco, is the corresponding author.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi:10.1001/jamanetworkopen.2023.2338)
Editor’s ...
BOSTON – Hypertension is the leading risk factor for death worldwide. During the COVID-19 pandemic, routine blood pressure assessments decreased because of global disruptions to medical care delivery. However, new research has found that a remote hypertension program, operated by Mass General Brigham since 2019, successfully supported patients through the pandemic in achieving their blood pressure goals, with patients who enrolled during the pandemic reaching and maintaining their goal blood pressures an average of two months earlier than in the pre-pandemic period. The results, published in Journal ...
How strongly a vaccine protects you may depend on getting enough sleep in the days before and after inoculation, finds a new meta-analysis examining the relationship between sleep duration and the body’s response to vaccination.
Sleeping fewer than six hours per night around the time of vaccination was associated with a robust decrease in antibody response, according to the multi-institution study published March 13 in Current Biology. Adults are typically recommended to get between seven and nine hours of sleep per night.
The meta-analysis included data on the association between sleep duration and antibody responses for the ...
In reviewing data from previous studies, a team lead by researchers at the University of Chicago and the French National Institute of Health and Medical Research (Inserm) found that individuals who had fewer than six hours of sleep per night in the days surrounding vaccination had a blunted antibody response. That indicates efforts to promote heathy sleep duration ahead of an immunization could be an easy way to improve vaccine effectiveness. The study was published March 13 in Current Biology.
The latest work builds off a 2002 study by members of the team showing that restricting sleep ...
While drugs are on the market to slow the progression of neurodegenerative diseases, there are still no cures. But researchers at Boston Children’s Hospital and Harvard Medical School are looking for new pathways for slowing neuronal dysfunction and treating amyotrophic lateral sclerosis (ALS), a fatal motor neuron disease. The team found that proteins involved in the innate immune system could be at the root of the disease.
“The unmet need for therapies for neurodegenerative diseases is huge, and our work opens up a whole new ...
SAN FRANCISCO, CA (March 13, 2023) — In a paper published today in Current Biology, researchers from the California Academy of Sciences Hope for Reefs initiative, along with Brazilian collaborators from the University of São Paulo, Federal University of Espírito Santo, and the Instituto Nacional da Mata Atlântica, show that mesophotic coral reefs function much differently than their shallower counterparts and are unlikely to offer a refuge for shallow water fishes trying to escape climate-change driven warming on the ocean’s surface.
The research is based on hundreds of dives totaling ...
Achieving the goals of the Paris Climate Agreement will require the combined efforts of states and companies around the world. How can developing countries achieve carbon neutrality and boost their resilience while pursuing economic growth and improved living standards? A study by the Research Institute for Sustainability (RIFS) draws on the example of Nepal to analyse the benefits of a net-zero emissions strategy.
Nepal is among the 10 countries most vulnerable to climate-change-related disasters and risks. However, its contribution to global greenhouse gas emissions is minor. As Nepal prepares to graduate ...
In 1957, Maurice Raben successfully isolated and purified the growth hormone (GH) from the pituitary gland, opening up a potential avenue of GH therapies. Children who were born with a deficiency of this hormone could now receive medical intervention in the form of daily injections to substitute the product into their body, thus avoiding the ill-effects of GH deficiency. However, given that it was a product that had to be meticulously extracted from the pituitary of dead bodies, and was time-consuming as well as labor- and resource-intensive process, it remained ...
Materials science is constantly evolving research area as researchers strive to discover and synthesize novel functional materials with desirable properties suited to a variety of applications. One example on this front is furnished by covalent organic frameworks (COFs), a class of materials characterized by crystalline porous polymers connected in the form of a network via covalent bonds.
Owing to their structural diversity, high porosity, and easily accessible active sites, COFs can be designed for a range of applications such as gas storage and separation, catalysis, and drug delivery. ...
