BetaLife and A*STAR Collaborate to develop next generation cell-based therapy for diabetes treatment
(Press-News.org) Up-and-coming local biotech startup BetaLife Pte Ltd (“BetaLife”) is collaborating with the Agency for Science, Technology and Research (A*STAR) to accelerate the development of next generation cell-based therapy for diabetes. BetaLife, a stem cell therapy company focused on developing regenerative medicine for diabetes, has acquired the rights to human induced Pluripotent Stem Cell (iPSC) technology from A*STAR. This technology enables the generation of iPSCs, which are cells that have similar properties to embryonic stem cells, to provide a renewable and sustainable human stem cell resource to generate any mature cell type of interest. Such iPSC-derived cells can potentially be used to regenerate or replace defective tissues in human patients.
According to the International Diabetes Federation, over 530 million1 people worldwide live with diabetes, and human iPSC-based technology could potentially provide a curative treatment for this chronic disease. In a healthy individual, food that is taken in is broken down into sugar (glucose), which triggers the pancreas to release insulin. Insulin is produced by a specific cell type in the pancreatic islets known as beta cells, and is responsible for instructing cells in the body to utilise glucose for energy. Diabetes may arise when the beta cells do not release enough insulin. Prolonged periods of high glucose in the blood can give rise to diabetic complications that lead to heart disease, kidney failure and blindness.
“Pancreatic beta cells derived in the lab from human iPSCs not only provide a cell model for diabetes research, but may even be developed into a regenerative medicine product to help patients regain control of their blood glucose levels,” said Dr Adrian Teo, Principal Investigator at A*STAR Institute of Molecular and Cell Biology (A*STAR IMCB) and Scientific Co-Founder of BetaLife.
To accelerate development efforts, BetaLife and A*STAR are embarking on a research collaboration, with the goal of generating highly curated human iPSC banks that capture the genetic diversity of Asian ethnicities, and develop human iPSC-derived pancreatic islet cells. This collaboration combines A*STAR’s capabilities in stem cells and diabetes biology with BetaLife’s infrastructure and proprietary platforms for the scale up and therapeutic development of an off-the-shelf human iPSC-based therapy.
“This collaboration paves the way for a proof-of-concept that islet cell-based therapy can help treat diabetes. Our efforts to extend the excellent science from A*STAR will enable BetaLife to further develop the cells for future human trials,” said Dr Lim Kah Meng, Managing Director of BetaLife.
Professor Hong Wanjin, Executive Director at A*STAR IMCB, said, “Diabetes is very prevalent among Singaporeans. It is heartening to witness how A*STAR’s R&D is able to empower local biotech companies to advance treatment for diabetes patients and contribute towards better health and societal outcomes.”
– END –
[Attachments] See images for this press release:
ELSE PRESS RELEASES FROM THIS DATE:
The Cinereous Vulture (Aegypius monachus) - also known as Black Vulture, Monk Vulture or Eurasian Black Vulture - is the largest bird of prey in Europe.
Globally classified as Near Threatened, its populations in southern Europe, once abundant, have been experiencing a dramatic decline since the late 1800s. So dramatic, in fact, that by the mid-1900s, these birds had already been nowhere to be seen throughout most of their distributional range across the Old Continent. In Bulgaria, the species has been considered locally extinct since 1985.
Thanks to the re-introduction initiative that was started in 2015 by three Bulgarian non-governmental organisations: ...
Nine in ten women in England enter pregnancy with at least one indicator that may increase health risks to them and their baby, according to new research.
Common indicators were women not quitting smoking, failing to take folic acid before pregnancy or having a previous pregnancy loss.
Researchers from the NIHR Southampton Biomedical Research Centre, hosted by University Hospital Southampton and University of Southampton, analysed data from over 650,000 mothers.
They created a first national picture of women’s health before ...
"Have you ever wondered about life on a leaf?"
Great Lakes Bioenergy Research Center (GLBRC) researcher Ashley Shade asks a simple question, but it’s one well worth investigation. The aboveground part of plants where microbes reside, or the phyllosphere, represents the largest environmental surface area on the plant. Much of this area is grown as cultivated agriculture, and understanding the interactions between plants and the microorganisms that live on their surfaces may help us develop agricultural management practices that can increase crop productivity and resilience. In their newly published study, Department ...
ITHACA, N.Y. – Moderate levels of artificial light at night – like the fixture illuminating your backyard – bring more caterpillar predators and reduce the chance that these lepidoptera larvae grow up to become moths and serve as food for larger prey.
This ecological impact was demonstrated in a new Cornell University study published in the Proceedings of the Royal Society B: Biological Sciences.
The scientists placed more than 550 lifelike caterpillar replicas made of soft clay in a forest, setting to ascertain how the mockups were attacked and hunted by predators compared to a control group.
“We measured predation ...
The Fannie and John Hertz Foundation is proud to announce that Anne Kornahrens, Director of Community, has been selected as a 2023 U.S. delegate to the International Younger Chemists Network (IYCN) Assembly.
Kornahrens will attend the 52nd International Union of Pure and Applied Chemistry (IUPAC) General Assembly and World Chemistry Congress, to be held in The Hague, Netherlands, August 18–25, 2023.
The IUPAC Young Observer Program strives to introduce the work of IUPAC to a new generation of distinguished researchers and to provide them with an opportunity to address international science policy issues. IYCN, an affiliated ...
SAN ANTONIO (March 21, 2023) — Researchers from The University of Texas Health Science Center at San Antonio (UT Health San Antonio) have developed a small-molecule drug that prevents weight gain and adverse liver changes in mice fed a high-sugar, high-fat Western diet throughout life.
“When we give this drug to the mice for a short time, they start losing weight. They all become slim,” said Madesh Muniswamy, PhD, professor of medicine in the health science center’s Joe R. and Teresa Lozano Long School of Medicine.
Findings by the collaborators, also from the University of Pennsylvania and Cornell University, were published Feb. 27 in the high-impact journal Cell ...
WASHINGTON, D.C. - Today, the U.S. Department of Energy (DOE) announced $150 million for research into the crosscutting foundational science for multiple Energy Earthshots. This funding, provided by the Office of Science, will support fundamental research to accelerate breakthroughs in support of the Energy Earthshots Initiative.
“Our Energy Earthshot solutions start with science,” said Asmeret Asefaw Berhe, DOE’s Director of the Office of Science. “The Office of Science is working to find those solutions by supporting research that will target the remaining and emerging scientific challenges underlaying ...
EAST LANSING, Mich. – While listening to a favorite song is a known mood booster, researchers at Michigan State University have discovered that music-listening interventions also can make medicines more effective.
“Music-listening interventions are like over-the-counter medications,” said Jason Kiernan, an assistant professor in the College of Nursing. “You don’t need a doctor to prescribe them.”
While previous research studies have used music-listening interventions as a tool to treat pain and anxiety, Kiernan took a novel approach by studying the effects of music-listening interventions ...
URBANA, Ill. – Animal agriculture is a major source of water pollution in the United States, as manure runoff carries excess nutrients into rivers and lakes. Because of their non-point source nature, most farms are not regulated under the federal Clean Water Act. This leaves pollution control up to the states, resulting in a patchwork of different approaches that are difficult to evaluate.
A new study from the University of Illinois focuses on local manure management regulations in Wisconsin and how they affect water ...
Abu Dhabi, UAE, March 21, 2023 – A team of NYU Abu Dhabi (NYUAD) researchers, including data and computational social scientists, is reporting new findings that highlight previously unknown ways through which non-White scientists suffer from inequalities when it comes to the process of having their research considered, published, and cited, potentially hindering the advancement of their academic careers. Specifically, the NYUAD team’s analysis found fewer non-White editors than would be expected based on their share of authorship. In addition, non-White scientists endure longer waiting times between the submission ...
LAST 30 PRESS RELEASES:
[Press-News.org] BetaLife and A*STAR Collaborate to develop next generation cell-based therapy for diabetes treatment