(Press-News.org) SAN ANTONIO (March 21, 2023) — Researchers from The University of Texas Health Science Center at San Antonio (UT Health San Antonio) have developed a small-molecule drug that prevents weight gain and adverse liver changes in mice fed a high-sugar, high-fat Western diet throughout life.
“When we give this drug to the mice for a short time, they start losing weight. They all become slim,” said Madesh Muniswamy, PhD, professor of medicine in the health science center’s Joe R. and Teresa Lozano Long School of Medicine.
Findings by the collaborators, also from the University of Pennsylvania and Cornell University, were published Feb. 27 in the high-impact journal Cell Reports. Muniswamy, director of the Center for Mitochondrial Medicine at UT Health San Antonio, is the senior author.
Fourth most common element
The research team discovered the drug by first exploring how magnesium impacts metabolism, which is the production and consumption of energy in cells. This energy, called ATP, fuels the body’s processes.
Magnesium is the fourth most abundant element in the body after calcium, potassium and sodium, and plays many key roles in good health, including regulating blood sugar and blood pressure and building bones. But the researchers found that too much magnesium slows energy production in mitochondria, which are cells’ power plants.
“It puts the brake on, it just slows down,” said co-lead author Travis R. Madaris, doctoral student in the Muniswamy laboratory at UT Health San Antonio.
Deleting MRS2, a gene that promotes magnesium transport into the mitochondria, resulted in more efficient metabolism of sugar and fat in the power plants. The result: skinny, healthy mice.
Liver and adipose (fat) tissues in the rodents showed no evidence of fatty liver disease, a complication related to poor diet, obesity and type 2 diabetes.
The drug, which the researchers call CPACC, accomplishes the same thing. It restricts the amount of magnesium transfer into the power plants. In experiments, the result was again: skinny, healthy mice. UT Health San Antonio has filed a patent application on the drug.
The mice served as a model system of long-term dietary stress precipitated by the calorie-rich, sugary and fatty Western diet. The familiar results of this stress are obesity, type 2 diabetes and cardiovascular complications.
“Lowering the mitochondrial magnesium mitigated the adverse effects of prolonged dietary stress,” said co-lead author Manigandan Venkatesan, PhD, postdoctoral fellow in the Muniswamy lab.
Joseph A. Baur, PhD, of the University of Pennsylvania and Justin J. Wilson, PhD, of Cornell are among the collaborators. “We came up with the small molecule and Justin synthesized it,” Madaris said.
“These findings are the result of several years of work,” Muniswamy said. “A drug that can reduce the risk of cardiometabolic diseases such as heart attack and stroke, and also reduce the incidence of liver cancer, which can follow fatty liver disease, will make a huge impact. We will continue its development.”
Funders of this project include the National Institutes of Health, the U.S. Department of Defense and the San Antonio Partnership for Precision Therapeutics.
Limiting Mrs2-Dependent Mitochondrial Mg2+ Uptake Induces Metabolic Programming in Prolonged Dietary Stress
Travis R. Madaris, Manigandan Venkatesan, Soumya Maity, Miriam C. Stein, Neelanjan Vishnu, Mridula K. Venkateswaran, James G. Davis, Karthik Ramachandran, Sukanthathulse Uthayabalan, Cristel Allen, Ayodeji Osidele, Kristen Stanley, Nicholas P. Bigham, Terry M. Bakewell, Melanie Narkunan, Amy Le, Varsha Karanam, Kang Li, Aum Mhapankar, Luke Norton, Jean Ross, M. Imran Aslam, W. Brian Reeves, Brij B. Singh, Jeffrey Caplan, Justin J. Wilson, Peter B. Stathopulos, Joseph A. Baur and Muniswamy Madesh
First published: Feb. 27, 2023, Cell Reports
The University of Texas Health Science Center at San Antonio (UT Health San Antonio), a primary driver for San Antonio’s $44.1 billion health care and biosciences sector, is the largest academic research institution in South Texas with an annual research portfolio of $360 million. Driving substantial economic impact with its six professional schools, a diverse workforce of 7,900, an annual operating budget of $1.08 billion and clinical practices that provide 2.6 million patient visits each year, UT Health San Antonio plans to add more than 1,500 higher-wage jobs over the next five years to serve San Antonio, Bexar County and South Texas. To learn about the many ways “We make lives better®,” visit UTHealthSA.org.
Stay connected with The University of Texas Health Science Center at San Antonio on Facebook, Twitter, LinkedIn, Instagram and YouTube.
Novel drug makes mice skinny even on sugary, fatty diet
Compound limits magnesium transport in cellular power plants called mitochondria.
ELSE PRESS RELEASES FROM THIS DATE:
Department of Energy announces $150 million for research on the science foundations for Energy Earthshots
WASHINGTON, D.C. - Today, the U.S. Department of Energy (DOE) announced $150 million for research into the crosscutting foundational science for multiple Energy Earthshots. This funding, provided by the Office of Science, will support fundamental research to accelerate breakthroughs in support of the Energy Earthshots Initiative. “Our Energy Earthshot solutions start with science,” said Asmeret Asefaw Berhe, DOE’s Director of the Office of Science. “The Office of Science is working to find those solutions by supporting research that will target the remaining and emerging scientific challenges underlaying ...
Turn up your favorite song to improve medication efficacy
EAST LANSING, Mich. – While listening to a favorite song is a known mood booster, researchers at Michigan State University have discovered that music-listening interventions also can make medicines more effective. “Music-listening interventions are like over-the-counter medications,” said Jason Kiernan, an assistant professor in the College of Nursing. “You don’t need a doctor to prescribe them.” While previous research studies have used music-listening interventions as a tool to treat pain and anxiety, Kiernan took a novel approach by studying the effects of music-listening interventions ...
Local manure regulations can help reduce water pollution from dairy farms
URBANA, Ill. – Animal agriculture is a major source of water pollution in the United States, as manure runoff carries excess nutrients into rivers and lakes. Because of their non-point source nature, most farms are not regulated under the federal Clean Water Act. This leaves pollution control up to the states, resulting in a patchwork of different approaches that are difficult to evaluate. A new study from the University of Illinois focuses on local manure management regulations in Wisconsin and how they affect water ...
Analysis by NYUAD researchers offers new insights into causes of persistent inequities affecting non-white scientists and their research
Abu Dhabi, UAE, March 21, 2023 – A team of NYU Abu Dhabi (NYUAD) researchers, including data and computational social scientists, is reporting new findings that highlight previously unknown ways through which non-White scientists suffer from inequalities when it comes to the process of having their research considered, published, and cited, potentially hindering the advancement of their academic careers. Specifically, the NYUAD team’s analysis found fewer non-White editors than would be expected based on their share of authorship. In addition, non-White scientists endure longer waiting times between the submission ...
New compact and low-cost lensless radiomicroscope developed for nuclear medicine imaging
Reston, VA—A novel imaging modality that can visualize the distribution of medical radiopharmaceuticals with very fine resolution has been developed and successfully tested, according to research published in the March issue of The Journal of Nuclear Medicine. Known as the lensless radiomicroscope, the palm-sized instrument offers the same level of imaging performance as its closest imaging equivalent but comes with significantly larger field of view and costs less than $100. “While many nuclear medicine imaging modalities can quantitively measure ...
Patients with baclofen pumps may safely undergo transcutaneous spinal stimulation
East Hanover, NJ. March 21, 2023. Researchers from Kessler Foundation and Kessler Institute for Rehabilitation (collectively “Kessler”) conducted the first prospective study to assess whether transcutaneous spinal stimulation (TSS) interacts with implanted intrathecal baclofen (ITB) pump delivery systems for managing spasticity. The article, "Transcutaneous spinal stimulation in patients with intrathecal baclofen pump delivery system: A preliminary safety study," (doi: 10.3389/fnins.2022.1075293), was published December 21, 2022, in Frontiers in Neuroscience. It is ...
Co-infection with ‘superbug’ bacteria increases SARS-CoV-2 replication up to 15 times, Western study finds
Global data shows nearly 10 per cent of severe COVID-19 cases involve a secondary bacterial co-infection – with Staphylococcus aureus, also known as Staph A., being the most common organism responsible for co-existing infections with SARS-CoV-2. Researchers at Western have found if you add a ‘superbug’ – methicillin-resistant Staphylococcus aureus (MRSA) – into the mix, the COVID-19 outcome could be even more deadly. The mystery of how and why these two pathogens, when combined, ...
Advisory role: New research suggests peer-advisor relationship is key to success
Collaborative research across the country has shown that strengthening the relationship between the student and advisor can increase retention rates in engineering doctoral studies. Dr. Marissa Tsugawa, along with professors from Penn State, The University of Oregon, Indiana University Bloomington, University of Reno, Nevada and North Carolina State University, recently published a study with the Journal of Engineering Education on March 17. The study connects an engineering student’s identity and the intention to complete a Ph.D. in engineering. Identity is a role that students give themselves during their experiences in the lab and classroom. The authors argue ...
Researchers get to the “bottom” of how beetles use their butts to stay hydrated
Beetles are champions at surviving in extremely dry environments. In part, this property is due to their ability to suck water from the air with their rear ends. A new collaborative study by researchers from the University of Copenhagen and the University of Edinburgh explains just how. Beyond helping to explain how beetles thrive in environments where few other animals can survive, the knowledge could eventually be used for more targeted and delicate control of global pests such as the grain weevil and red flour beetle. Insect pests eat their way through thousands of tons of food around the world every year. Food security in developing ...
New MU study shapes understanding of adaptive clothing customer needs
With the growth of the niche adaptive clothing market comes new challenges for retailers, including making the process of online shopping more inclusive for people with varying degrees of disability as well as expanding the functionality and aesthetic appeal of individual garments. This study involved mining online reviews to understand the perspectives of adaptive clothing customers. University of Missouri researchers identified two main challenges for adaptive clothing consumers. Customers said ...
LAST 30 PRESS RELEASES:
Cancer survivors who quit smoking have 36% lower cardiovascular risk than continuers
More depressed patients than previously estimated could have increased activation of their immune system
Shedding light on the complex flow dynamics within the small intestine
UK cardiology societies issue joint policy statement to stamp out bullying, harassment, and discrimination in the specialty
Predominance of young Asian men among large UK case series of laughing gas users
Ketamine nasal spray may prove safe and effective treatment for refractory migraine
The clams that fell behind, and what they can tell us about evolution and extinction
Medical school does not equip new doctors for the real working world, junior doctor warns
Unique “bawdy bard” act discovered, revealing 15th-century roots of British comedy
Saved from extinction, Southern California’s Channel Island Foxes now face new threat to survival
Genetic change increased bird flu severity during U.S. spread
New Jersey Health Foundation awards grants to Kessler Foundation to advance research in brain and spinal cord stimulation methods
Extracting a clean fuel from water
NJIT researchers awarded $4.6m to unlock mysteries of solar eruptions
Extended lymph node removal does not benefit patients with clinically localized muscle-invasive bladder cancer
Study finds sex education tool improves reproductive health knowledge among adolescent girls
No-till revolution could stop Midwest topsoil loss in its tracks
Computational method uncovers the effects of mutations in the noncoding genome
Extreme precipitation in northeast to increase 52% by the end of the century
Lung infection may be less transmissible than thought
Experimental decoy protects against SARS-CoV-2 infection
Light conveyed by the signal transmitting molecule sucrose controls growth of plant roots
Mitigating climate change through restoration of coastal ecosystems
Flexible nanoelectrodes can provide fine-grained brain stimulation
Teens with irregular sleep patterns have higher risk of school problems
Genetic risk information may help people avoid alcohol addiction
Advances in technology are driving popularity of EVs
Newborns with higher hair cortisol levels take longer to fall asleep
That’s not nuts: Almond milk yogurt packs an overall greater nutritional punch than dairy-based
Using AI to create better, more potent medicines[Press-News.org] Novel drug makes mice skinny even on sugary, fatty diet
Compound limits magnesium transport in cellular power plants called mitochondria.