Neutralizing monoclonal antibody use and COVID-19 infection outcomes

JAMA Network Open

2023-04-24

(Press-News.org) About The Study: In this study that included 167,000 non-hospitalized patients, neutralizing monoclonal antibody (nMAb) treatment for COVID-19 was safe and associated with reductions in emergency department visits, hospitalization, and death, although it was not associated with reduced risk of hospitalization during the Omicron BA.1 epoch. These findings suggest that targeted risk stratification strategies may help optimize future nMAb treatment decisions.

Authors: Brian Anderson, M.D., of the MITRE Corporation in Bedford, Massachusetts, is the corresponding author.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamanetworkopen.2023.9694)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

# # #

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2023.9694?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=042423

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

END

ELSE PRESS RELEASES FROM THIS DATE:

New insights on the risk for atrial fibrillation in children and young adults

2023-04-24

Researchers at Karolinska Institutet in Sweden have investigated how preterm birth and foetal growth are related to the risk of atrial fibrillation up to middle-age. The study, which is published in JAMA Pediatrics, shows that being born preterm or large for gestational age was associated with increased risks of atrial fibrillation later in life. Being small for gestational age at birth was only associated with an increased risk of atrial fibrillation up to the age of 18. The incidence of atrial fibrillation in the young has increased over the past few decades, from low levels. “Atrial fibrillation at a young age may involve a heavy socioeconomic burden for the affected ...

Vaccine printer could help vaccines reach more people

2023-04-24

CAMBRIDGE, MA -- Getting vaccines to people who need them isn’t always easy. Many vaccines require cold storage, making it difficult to ship them to remote areas that don’t have the necessary infrastructure. MIT researchers have come up with a possible solution to this problem: a mobile vaccine printer that could be scaled up to produce hundreds of vaccine doses in a day. This kind of printer, which can fit on a tabletop, could be deployed anywhere vaccines are needed, the researchers say. “We could someday ...

Scientists have full state of a quantum liquid down cold

2023-04-24

A team of physicists has illuminated certain properties of quantum systems by observing how their fluctuations spread over time. The research offers an intricate understanding of a complex phenomenon that is foundational to quantum computing—a method that can perform certain calculations significantly more efficiently than conventional computing. “In an era of quantum computing it’s vital to generate a precise characterization of the systems we are building,” explains Dries Sels, an assistant ...

Massive iceberg discharges during the last ice age had no impact on nearby Greenland, raising new questions about climate dynamics

2023-04-24

CORVALLIS, Ore. – During the last ice age, massive icebergs periodically broke off from an ice sheet covering a large swath of North America and discharged rapidly melting ice into the North Atlantic Ocean around Greenland, triggering abrupt climate change impacts across the globe. These sudden episodes, called Heinrich Events, occurred between 16,000 and 60,000 years ago. They altered the circulation of the world’s oceans, spurring cooling in the North Atlantic and impacting monsoon rainfall around the world. But ...

New biologic effective against major infection in early tests

2023-04-24

Researchers at NYU Grossman School of Medicine and Janssen Biotech, Inc. have shown in early tests that a bioengineered drug candidate can counter infection with Staphylococcus aureus – a bacterial species widely resistant to antibiotics and a major cause of death in hospitalized patients. Experiments demonstrated that SM1B74, an antibacterial biologic agent, was superior to a standard antibiotic drug at treating mice infected with S. aureus, including its treatment-resistant form known as MRSA. Published ...

Researchers develop new tools for precise large DNA insertions

2023-04-24

GAO Caixia's group from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences (CAS) has developed a new genome editing technology that achieves efficient and precise targeted insertion of large DNA segments in plants. The new technology, called prime editing-mediated recombination of opportune targets (PrimeRoot), combines an optimized dual-ePPE editor protein previously published by the group with a highly efficient tyrosine site-specific recombinase, Cre. It can achieve ...

Researchers ID novel treatment pathway for deadly pancreatic cancers

2023-04-24

Researchers at the Johns Hopkins Kimmel Cancer Center identified a novel cell signaling pathway that potentially could be targeted in therapy for patients with aggressive pancreatic cancers. In laboratory studies with human pancreatic cancer cell lines and genetically engineered mouse models of pancreatic cancer, the investigators discovered that the High Mobility Group A1 (HMGA1) protein functions as a “molecular switch” that “flips on” genes required by tumor cells to grow in an uncontrolled fashion and form invasive tumors. One of these genes activated ...

Maternal and early-life high-fat diets result in a taste for salty food

2023-04-24

Tokyo, Japan – We are all aware of the importance of eating healthy food, especially during pregnancy. A high-fat diet has dramatic consequences on the metabolism. It can lead to obesity, diabetes, chronic liver disease, and possibly cancer. Previous works have demonstrated that eating high amounts of fat during pregnancy affects the taste preference and metabolism in offspring. In most households, children and parents eat the same food. In other words, mums eating a high-fat diet will likely feed their children fatty foods. What are the consequences of maternal ...

NFL PLAY 60 Fitness Break broadcast keeps kids active in advance of the NFL Draft

2023-04-24

DALLAS, April 24, 2023 — The American Heart Association and the National Football League (NFL), in collaboration with its 32 NFL clubs, are challenging kids to move more with an NFL PLAY 60 Fitness Break for the NFL Draft happening later this week. The free program on Wednesday, April 26 at 1 p.m. ET/ 12 p.m. CT/ 10 a.m. PT will offer a 15-minute synchronous broadcast to help students learn how to add movement to their day leading up to the live Draft coverage from Kansas City. Rooted in American Heart Association science, the Fitness Break broadcast helps students learn more about how physical activity supports ...

A panoramic view on lithium-mediated electrochemical dinitrogen reduction reaction

2023-04-24

The Haber-Bosch process is the industrial approach for NH3 production today, which must be operated at energy-intensive high temperatures and pressures. The reduction of dinitrogen (N2) by electrocatalysis offers an alternative way for NH3 production at ambient conditions and a variety of electrocatalysts have been studied over the past few years. However, even the best catalytic system reported could only get unsatisfied performance (such as the selectivity and production rate of NH3) due to the ...

LAST 30 PRESS RELEASES:

SwRI-led Lucy mission survey of main belt asteroid Donaldjohanson imminent

New bat cell lines and reagents help to study bat antiviral immune responses against hantaviruses and coronaviruses

Preterm birth might be predicted with high accuracy with new cheap, non-invasive test, based on cell-free DNA collected in standard early pregnancy testing