PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Novel therapeutic strategy against melanoma: combined targeting of hedgehog signaling and BRD4

Novel therapeutic strategy against melanoma: combined targeting of hedgehog signaling and BRD4
2023-07-19
(Press-News.org)

“This evidence strengthens the relevance of the findings by Pietrobono et al., shedding light on the potential application of SMO inhibitors in concert with BRD4 inhibitors.”

BUFFALO, NY- July 19, 2023 – A new editorial paper was published in Oncotarget's Volume 14 on May 26, 2023, entitled, “Combined targeting of HEDGEHOG signaling and BRD4 as a novel therapeutic option against melanoma.”

The Hedgehog-GLI (HH/GLI) pathway is aberrantly activated in several types of cancer. Canonical HH/ GLI pathway is triggered by binding of HH ligands to the twelve-pass transmembrane receptor Patched 1 (PTCH1), which retrieves its inhibition on the seven-pass transmembrane G protein-coupled receptor Smoothened (SMO), leading to the activation of the GLI transcription factors. Small molecules inhibitors targeting the essential pathway transducer SMO (e.g., vismodegib, sonidegib) have demonstrated therapeutic efficacy in HH-dependent tumors, such as basal cell carcinoma (BCC) and medulloblastoma (MB). 

However, the therapeutic efficacy of these SMO antagonists is limited by the development of acquired resistance and recurrence after drug withdrawal, and by additional oncogenic signals responsible for noncanonical activation of GLI transcription factors [1]. In this new editorial, researchers Silvia Pietrobono and Barbara Stecca from the University of Verona and the Institute for Cancer Research and Prevention (CRL-ISPRO) state that they subscribe to the idea that targeting non-canonical HH/GLI signaling will improve the response rate and durability of therapeutic effects exerted by SMO inhibition. Therefore, they propose that the identification of novel targetable regulators that function downstream of SMO, especially those acting at the transcriptional level, is of critical importance to effectively inhibit the HH pathway and prevent tumor relapse.

“Collectively, the findings presented by Pietrobono et al. pave the path for the development of a novel therapeutic strategy in tumors having both canonical and non-canonical HH/GLI signaling activation, such as melanoma.”
 

Read the full editorial: DOI: https://doi.org/10.18632/oncotarget.28441 

Correspondence to: Silvia Pietrobono, Barbara Stecca

Emails: silvia.pietrobono@univr.it, b.stecca@ispro.toscana.it 

Keywords: melanoma, hedgehog signaling, BRD4, SOX2, GLI1
 

About Oncotarget: Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

To learn more about Oncotarget, visit Oncotarget.com and connect with us on social media:

Twitter  Facebook  YouTube  Instagram  LinkedIn  Pinterest  LabTube Soundcloud

 

Sign up for free Altmetric alerts about this article: https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28441

Click here to subscribe to Oncotarget publication updates.

For media inquiries, please contact: media@impactjournals.com.

 

Oncotarget Journal Office

6666 East Quaker Str., Suite 1A

Orchard Park, NY 14127

Phone: 1-800-922-0957 (option 2)

###

END


[Attachments] See images for this press release:
Novel therapeutic strategy against melanoma: combined targeting of hedgehog signaling and BRD4 Novel therapeutic strategy against melanoma: combined targeting of hedgehog signaling and BRD4 2

ELSE PRESS RELEASES FROM THIS DATE:

Large study finds small associations between systemic inflammation and later dementia

Large study finds small associations between systemic inflammation and later dementia
2023-07-19
A study of data from about 500,000 people in the UK Biobank has uncovered small but statistically significant associations between signs of systemic inflammation and later risk of dementia. Dr. Krisztina Mekli of The University of Manchester, UK, and colleagues present these findings in the open-access journal PLOS ONE on July 19, 2023. Millions of people around the world have Alzheimer’s disease or other types of dementia, and researchers are working to tease out the complex mechanisms behind these conditions. Prior research has suggested that inflammation—activation of the body’s innate immune system—may ...

STEM instructors who are women drive disclosure of concealable stigmatized identities to undergraduates

STEM instructors who are women drive disclosure of concealable stigmatized identities to undergraduates
2023-07-19
Women working as STEM instructors are more likely than men in the same profession to disclose to their undergraduate students identities which could carry stigma, such as depression or growing up in a low-income household. In the new study, published July 19, 2023 in the open-access journal PLOS ONE, Carly Busch of Arizona State University, USA, and colleagues suggest that these decisions to disclose may be in order to act as role models for students. Concealable stigmatized identities (CSIs) are identities that ...

Researchers used a LEGO robotics kit as a cheap, effective way to purify self-assembling DNA origami

Researchers used a LEGO robotics kit as a cheap, effective way to purify self-assembling DNA origami
2023-07-19
Article URL:  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0283134 Article Title: Gradient-mixing LEGO robots for purifying DNA origami nanostructures of multiple components by rate-zonal centrifugation Author Countries: USA Funding: The research in Hariadi lab was supported by the National Institutes of Health Director’s New Innovator Award (1DP2AI144247), National Science Foundation SemiSynBio II (2027215), and Arizona Biomedical Research Consortium (ADHS17-00007401). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. END ...

A 300,000 year-old double-pointed wooden stick was produced by Middle Pleistocene humans using sophisticated woodworking techniques and was likely used for throwing during hunts

A 300,000 year-old double-pointed wooden stick was produced by Middle Pleistocene humans using sophisticated woodworking techniques and was likely used for throwing during hunts
2023-07-19
Article URL:  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0287719 Article Title: A double-pointed wooden throwing stick from Schöningen, Germany: Results and new insights from a multianalytical study Author Countries: UK, Germany Funding: T.T. and this project are funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) – project number 447423357. https://www.dfg.de/. The project is further funded by the Lower Saxony Ministry for Science and Culture, with funds from the Future Lower Saxony Programme of the Volkswagen Foundation – project ...

1 in 5 rabbit owners in the UK report painful or debilitating ear disease in their pet, though it may be under-diagnosed and under-treated, with lop-eared and older rabbits being most at risk

1 in 5 rabbit owners in the UK report painful or debilitating ear disease in their pet, though it may be under-diagnosed and under-treated, with lop-eared and older rabbits being most at risk
2023-07-19
Article URL:  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0285372 Article Title: Ear health and quality of life in pet rabbits of differing ear conformations: A UK survey of owner-reported signalment risk factors and effects on rabbit welfare and behaviour Author Countries: UK Funding: The authors received no specific funding for this work. M.R.D.K included some of this questionnaire in part-fulfilment of her Bachelor of Veterinary Medicine at Royal Veterinary College. ...

CHOP researchers reveal how NSAIDs worsen C. difficile infections

2023-07-19
Philadelphia, July 19, 2023—Why do nonsteroidal anti-inflammatory drugs (NSAIDs) exacerbate gastrointestinal infections by Clostridioides difficile, the leading cause of antibiotic-associated diarrhea worldwide? In a new paperpublished in Science Advances, researchers at Children’s Hospital of Philadelphia (CHOP) have begun to answer that question, showing that NSAIDs disrupt the mitochondria of cells lining the colon, sensitizing them to damage by pathogenic toxins.  Clostridioides ...

Early humans were weapon woodwork experts, study finds

Early humans were weapon woodwork experts, study finds
2023-07-19
A 300,000-year-old hunting weapon has shone a new light on early humans as woodworking masters, according to a new study. State-of-the-art analysis of a double-pointed wooden throwing stick, found in Schöningen in Germany three decades ago, shows it was scraped, seasoned and sanded before being used to kill animals. The research indicates early humans’ woodworking techniques were more developed and sophisticated than previously understood. The findings, published today (Wednesday, 19 July) in PLOS ONE, also suggest the ...

New therapeutic target for Parkinson’s disease discovered

2023-07-19
·  Contacts between lysosomes and mitochondria are broken due to Parkinson’s mutation ·  Lysosomes cannot ‘feed’ mitochondria with essential metabolites  CHICAGO --- Northwestern Medicine scientists have uncovered a new mechanism by which mutations in a gene parkin contribute to familial forms of Parkinson's disease. The discovery opens a new avenue for Parkinson’s therapeutics, scientists report in a new study.  The Northwestern scientists discovered that mutations in parkin result in a breakdown ...

Enabling autonomous exploration

Enabling autonomous exploration
2023-07-19
A research group in Carnegie Mellon University's Robotics Institute is creating the next generation of explorers — robots. The Autonomous Exploration Research Team has developed a suite of robotic systems and planners enabling robots to explore more quickly, probe the darkest corners of unknown environments, and create more accurate and detailed maps. The systems allow robots to do all this autonomously, finding their way and creating a map without human intervention. "You can set it in any environment, like a department store or a residential building after a disaster, and off it goes," ...

More than just lifestyle and genes: New factor influencing excess body weight discovered

More than just lifestyle and genes: New factor influencing excess body weight discovered
2023-07-19
What determines whether we become overweight? Aside from lifestyle, predisposition plays a role, but genes cannot fully explain the inherited propensity to accumulate excess weight. A new study by Charité – Universitätsmedizin Berlin in Science Translational Medicine* shows that a kind of formatting of the DNA code in one gene that is associated with satiety is implicated in a slightly elevated risk of excess body weight – at least in women. This “epigenetic marking” is established early on during the embryonic stage. People who are overweight, especially those who ...

LAST 30 PRESS RELEASES:

Indra's internet

Lymph nodes found to be key to successful cancer immunotherapy

Room-temperature terahertz device opens door to 6G networks

A hard look at geoengineering reveals global risks

When smoke signals danger: How Australian lizards evolved to escape fire

Beyond the surface: Atopic eczema linked to significantly higher risk of suicidal thoughts, major study finds

After weight loss regular exercise rather than GLP-1 weight-loss drug reduces leading cause of heart attack and strokes

EASD launches its first ever clinical practice guideline – the world’s first to focus on diabetes distress

Semaglutide provides powerful protection against diabetic retinopathy, the leading cause of blindness in working-age adults, Greek study suggests

Orforglipron taken orally once daily leads to significant body weight loss (ATTAIN-1 Study)

U of I researchers trace genetic code’s origins to early protein structures

Disease experts team up with Florida Museum of Natural History to create a forecast for West Nile virus

Researchers: Targeted efforts needed to stem fentanyl crisis

New UMaine research could help lower prescription drug costs

Molecular movie shows how mitochondria read their DNA

Loss of key male fertility gene leads to changes in expression of hundreds of other genes

Water’s density is key to sustainable lithium mining

Pioneering research reveals problem gambling quadruples the risk of suicide among young people four years later

New method improves the accuracy of machine-learned potentials for simulating catalysts

Astronomers discover rare Einstein cross with fifth image, revealing hidden dark matter

UCalgary researchers show brain shunts significantly benefit older adults with hydrocephalus

UCalgary researchers pursue new approach to manage deadly lung scarring

Psychotherapy can be readily integrated into brief “med-check” psychiatry visits

‘Wiggling’ atoms may lead to smaller, more efficient electronics

Alliance webinar highlights latest advances in cancer treatment

Climate change could drastically reduce aquifer recharge in Brazil

$1.7M DOD grant funds virtual cancer center to support research into military health

Brain organoids could unlock energy-efficient AI

AI-powered CRISPR could lead to faster gene therapies, Stanford Medicine study finds

Shared genetic mechanisms underpin social life in bees and humans

[Press-News.org] Novel therapeutic strategy against melanoma: combined targeting of hedgehog signaling and BRD4