PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

UCI researchers announce publication of an open-label clinical trial suggesting that N-acetylglucosamine restores neurological function in Multiple Sclerosis patients

Researchers say this dietary supplement reduced inflammation and neurodegeneration markers in patients already on FDA-approved immune therapy.

UCI researchers announce publication of an open-label clinical trial suggesting that N-acetylglucosamine restores neurological function in Multiple Sclerosis patients
2023-09-14
(Press-News.org) Irvine, CA – Sept. 14, 2023 – UCI researchers have found that a simple sugar, N-acetylglucosamine, reduces multiple inflammation and neurodegeneration markers in people who suffer from multiple sclerosis (MS). In addition, they also found this dietary supplement improved neurological function in 30% of patients.

According to the World Health Organization, MS affects more than 1.8 million people, and while there are treatments to prevent relapses and improve quality of life, there is no cure.

The study, N-acetylglucosamine inhibits inflammation and neurodegeneration markers in multiple sclerosis: a mechanistic trial, was published in the Journal of Neuroinflammation. Michael Demetriou, MD, PhD, Chief of the Division of Multiple Sclerosis and Neuroimmunology at UCI, is the lead investigator of the study. Michael Y. Sy, MD, PhD, Director of the Neuroimmunology Fellowship at UCI School of Medicine, is the first author, and Barbara Newton, MD, Project Scientist at UCI, is the second author.

A major issue with current therapies in MS is the inability to treat chronic-active neuroinflammation in the brain and the associated failure to repair the loss of myelin that covers and protects axons, the electrical wires of the brain. Over time, this leads to permanent nerve cell damage and slow progressive loss of neurological function in patients.

“Our previous studies in mice and humans implicated N-acetylglucosamine in suppressing brain inflammation, promoting the re-growth of the myelin sheath and slowing brain degeneration,” said Michael Demetriou, MD, PhD, Professor of Neurology and Microbiology & Molecular Genetics at the UCI School of Medicine.

The new paper reports on the first clinical trial of N-acetylglucosamine in MS patients to directly investigate these potential activities. The trial was developed and performed exclusively in the Demetriou Lab at the UCI School of Medicine and UCI’s Institute of Clinical and Translational Science.

Researchers found that N-acetylglucosamine was safe and reduced multiple inflammation and neurodegeneration markers in MS patients despite the patients already being on the FDA approved immunomodulatory therapy Glatiramer Acetate, known to impact these pathways outside the brain.  

“We also observed a sustained reduction in neurological disability in 30% of the patients, an activity which has not been observed with current FDA approved therapies,” said Michael Y. Sy, MD, PhD, Associate Professor of Neurology, UCI School of Medicine. “They at best slow progression, not improve function.”

The data suggest that N-acetylglucosamine reduced untreated chronic-active neuroinflammation and/or promoted myelin repair.  However, the researchers stress that the trial was unblinded and therefore future blinded studies and additional parameters are essential to validate N-acetylglucosamine’s potential to improve residual chronic-active brain inflammation, myelin repair, neurodegeneration and neurological function in MS.

“Future studies demonstrating that N-acetylglucosamine can restore neurological function in MS patients would be a gamechanger and provide something that no other current therapy can do,” said Dr. Demetriou, MD, PhD.

 

UCI School of Medicine:

Each year, the UCI School of Medicine educates more than 400 medical students and nearly 150 PhD and MS students. More than 700 residents and fellows are trained at the UCI Medical Center and affiliated institutions. Multiple MD, PhD and MS degrees are offered. Students are encouraged to pursue an expansive range of interests and options. For medical students, there are numerous concurrent dual degree programs, including an MD/MBA, MD/MPH, or an MD/MS degree through one of three mission-based programs: the Health Education to Advance Leaders in Integrative Medicine (HEAL-IM), the Program in Medical Education for Leadership Education to Advance Diversity-African, Black and Caribbean (PRIME LEAD-ABC), and the Program in Medical Education for the Latino Community (PRIME-LC). The UCI School of Medicine is accredited by the Liaison Committee on Medical Accreditation and ranks among the top 50 nationwide for research. For more information, visit medschool.uci.edu.

  END

[Attachments] See images for this press release:
UCI researchers announce publication of an open-label clinical trial suggesting that N-acetylglucosamine restores neurological function in Multiple Sclerosis patients UCI researchers announce publication of an open-label clinical trial suggesting that N-acetylglucosamine restores neurological function in Multiple Sclerosis patients 2 UCI researchers announce publication of an open-label clinical trial suggesting that N-acetylglucosamine restores neurological function in Multiple Sclerosis patients 3

ELSE PRESS RELEASES FROM THIS DATE:

Vocal learning linked to problem solving skills and brain size

Vocal learning linked to problem solving skills and brain size
2023-09-14
The European starling boasts a remarkable repertoire. Versatile songbirds that learn warbles, whistles, calls, and songs throughout their lives, starlings rank among the most advanced avian vocal learners. Now a new study published in Science finds that starlings, along with other complex vocal learners, are also superior problem solvers. “There is a long-standing hypothesis that only the most intelligent animals are capable of complex vocal learning,” says Jean-Nicolas Audet, a research ...

Study finds spiritual coping behaviors may be key to enhanced trauma recovery of Black men who survive firearm injury

Study finds spiritual coping behaviors may be key to enhanced trauma recovery of Black men who survive firearm injury
2023-09-14
PHILADELPHIA (September 14, 2023) – High rates of firearm injury among urban Black men in the U.S. can lead to long physical and psychological recovery times, worsened by limited access to mental health services. In the face of firearm injury, urban Black men may feel they have lost control over their lives, leading to fear, paranoia, lack of forgiveness, and different dimensions of mental health challenges, which can be difficult to overcome. In a pilot study from the  University of Pennsylvania School of Nursing ...

In the “I” of the beholder: People believe self-relevant artwork is more beautiful

2023-09-14
People have fairly consistent preferences when it comes to judging the beauty of things in the real world—it’s well known, for example, that humans prefer symmetrical faces. But our feelings about art may be more personal, causing us to prefer art that speaks to our sense of self, research in Psychological Science suggests.  “When there is personal meaning in an image, that can dominate your aesthetic judgments way more than any image feature,” said Edward A. Vessel (The City College of New York) in an interview. Though self-relevant ...

Aspergillus fumigatus is a saprotrophic fungus that can cause serious life-threatening invasive infections in immunocompromised individuals

Aspergillus fumigatus is a saprotrophic fungus that can cause serious life-threatening invasive infections in immunocompromised individuals
2023-09-14
Aspergillus fumigatus is a saprotrophic fungus that can cause serious life-threatening invasive infections in immunocompromised individuals; by constructing a recombination map, this study shows that A. fumigatus produces the highest number of crossovers per chromosome ever described (~30 per chromosome pair). ##### In your coverage, please use this URL to provide access to the freely available paper in PLOS Biology:   http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002278 Article Title: The human fungal pathogen Aspergillus fumigatus can produce ...

During failure of core protein quality control in the nematode C. elegans, a specialized anti-aggregation mechanism relying on pathogen response factors and lysosomal mediated degradation is triggered

During failure of core protein quality control in the nematode C. elegans, a specialized anti-aggregation mechanism relying on pathogen response factors and lysosomal mediated degradation is triggered
2023-09-14
During failure of core protein quality control in the nematode C. elegans, a specialized anti-aggregation mechanism relying on pathogen response factors and lysosomal mediated degradation is triggered, promoting tissue-specific resilience to age-dependent protein aggregation and its proteotoxicity. ##### In your coverage, please use this URL to provide access to the freely available paper in PLOS Biology: http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002284 Article Title: A safety mechanism enables tissue-specific resistance to protein aggregation during aging in C. ...

How a molecule deletes neural chat might help treat Angelman syndrome

How a molecule deletes neural chat might help treat Angelman syndrome
2023-09-14
Researchers from the University of Tokyo reveal how the presynaptic Ube3a E3 ligase, a causal factor in Angelman syndrome, eliminates neural chat. The study helps find a better drug target for the Angelman syndrome treatment.  Neurons chat through electrical signals, transmitting information via connection sites between neurons—the synapses. After birth, the number of synapses increases. During childhood, the brain starts to mature and removes many unnecessary synapses. But sometimes, the development of the nervous system goes awry, leading to developmental disorders.  Kotaro ...

In songbirds, complex vocal learning predicts problem-solving abilities and brain size

2023-09-14
Vocal learning complexity, or the ability to imitate sounds, is associated with better problem-solving abilities and larger brains in songbird species, according to a new study. Whether vocal learning complexity was linked with such cognitive phenotypes was previously unknown. The approach used in the study, to study a lineage of birds, serves as a model for testing similar patterns in other vocal learning species. Complex vocal learning – the ability to imitate heard sounds – is a crucial component of human spoken language and has been assumed to be associated with more advanced cognitive abilities. Outside of humans, it has ...

Governance reforms could strengthen the Sustainable Development Goal implementation

2023-09-14
In a Policy Forum, Frank Biermann and colleagues outline demanding – yet realistic – policy reforms to strengthen the governance and implementation of the United Nations’ (UN) ambitious Sustainable Development Goals (SDGs). In 2015, the UN General Assembly agreed on 17 SDGs with 169 targets intended to be achieved by 2030. However, recent research has shown that the political impact of these goals has been limited and has not yet succeeded in reorienting political systems, institutions, or societies ...

Switching off the cytokine storm

Switching off the cytokine storm
2023-09-14
Constant exposure of cells to stressing agents, such as pathogens, may disturb an organism’s normal functioning. To fight stress, cells have developed several coping mechanisms, including the inflammatory response.  While inflammation is necessary, too much of it can impair cell and organ function. This is the case with cytokine storms – inflammatory cascades during an infection that can spiral out of control and lead to severe disease and even death, as recently highlighted during the COVID-19 pandemic. In a new paper published in Science, EMBL Grenoble and University ...

Specialised gut immune cells pinpointed that can limit progression of inflammatory bowel disease

2023-09-14
Researchers at the Francis Crick Institute, King’s College London and Guy’s and St Thomas’ NHS Foundation Trust have characterised a specialised type of immune cell, which plays a key role in protecting and repairing the cells in the healthy human gut. These protective immune cells are depleted in inflammatory bowel disease (IBD), leaving patients vulnerable to disease progression and severe complications. The findings could lead to better clinical management and treatment options for people living ...

LAST 30 PRESS RELEASES:

Tanzanian officials praise NEST360 contribution to newborn care

4D Medicine raises £3.4 million for unique biomaterial platform

Ancient marine animal had inventive past despite being represented by few species, new study finds

Quantum sensor for the atomic world developed through international scientific collaboration

The research was wrong: study shows moderate drinking won’t lengthen your life

Save your data on printable magnetic devices? New laser technique’s twist might make this reality

Early onset dementia more common than previously reported – the incidence of Alzheimer’s disease seems to be on the rise

Pesticides potentially as bad as smoking for increased risk in certain cancers

NUS researchers develop new battery-free technology to power electronic devices using ambient radiofrequency signals

New protein discovery may influence future cancer treatment

Timing matters: Scripps Research study shows ways to improve health alerts

New gene therapy approach shows promise for Duchenne muscular dystrophy

Chemical analyses find hidden elements from renaissance astronomer Tycho Brahe’s alchemy laboratory

Pacific Northwest launches clean hydrogen energy hub

Tiny deletion in heart muscle protein briefly affects embryonic ventricles but has long-term effects on adult atrial fibrillation

Harms of prescribing NSAIDs to high risk groups estimated to cost NHS £31m over 10 years

Wearing a face mask in public spaces cuts risk of common respiratory symptoms, suggests Norway study

Some private biobanks overinflating the value of umbilical cord blood banking in marketing to expectant parents

New research in fatty liver disease aims to help with early intervention

Genetics reveal ancient trade routes and path to domestication of the Four Corners potato

SNIS 2024: New study shows critical improvements in treating rare eye cancer in children

Wearable devices can increase health anxiety. Could they adversely affect health?

Addressing wounds of war

Rice researchers develop innovative battery recycling method

It’s got praying mantis eyes

Stroke recovery: It’s in the genes

Foam fluidics showcase Rice lab’s creative approach to circuit design

Montana State scientists publish evidence for new groups of methane-producing organisms

Daily rhythms depend on receptor density in biological clock

New England Journal of Medicine publishes outcomes from practice-changing E1910 trial for patients with BCR::ABL1-negative B-cell precursor acute lymphoblastic leukemia

[Press-News.org] UCI researchers announce publication of an open-label clinical trial suggesting that N-acetylglucosamine restores neurological function in Multiple Sclerosis patients
Researchers say this dietary supplement reduced inflammation and neurodegeneration markers in patients already on FDA-approved immune therapy.