PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Revolutionary breakthrough: human stomach micro-physiological system unveiled

The study findings have been published ahead of their official publication in the online version of Advanced Science on July 31, 2023

Revolutionary breakthrough: human stomach micro-physiological system unveiled
2023-09-27
(Press-News.org) A groundbreaking development in biomedical engineering has led to the creation of a human stomach micro-physiological system (hsMPS), representing a significant leap forward in understanding and treating various gastrointestinal diseases, including stomach cancer. The research team, led by Professor Tae-Eun Park from the Department of Biomedical Engineering at UNIST and Professor Seong-Ho Kong from Seoul National University Hospital, has successfully developed a biomimetic chip that combines organoid and organ-on-a-chip technologies to simulate the complex defense mechanisms of the human gastric mucosa.

Organoids, which mimic human organs using stem cells, have shown great potential as in vitro models for studying specific functions. However, they lack the ability to replicate mechanical stimulation or cell-to-cell interactions found within the human body. This limitation prompted researchers to develop an innovative biochip capable of recreating real-life gastric mucosal protection systems.

The newly developed biochip incorporates fluid flow within its microfluidic channels to simulate mechanical stimuli and facilitate cell-to-cell interactions. Mesenchymal substrate cells exposed to fluid flow activate gastric stem cell proliferation while promoting cellular differentiation balance. This process ultimately mimics key features necessary for developing functional gastric mucosal barriers at a biologically relevant level.

One remarkable achievement demonstrated by this hsMPS is its ability to uncover previously unseen defense mechanisms against Helicobacter pylori—a pathogen associated with various stomach diseases—in ways that were not possible with existing models. Gastric mucosal peptide known as TFF1 was observed forming mosaic-like structures within groups infected with Helicobacter pylori—forming a protective barrier essential for establishing an efficient defense system against external infectious factors. Suppression of gastric mucosal peptide expression resulted in more severe inflammatory reactions.

“This study presents our model’s potential for observing dynamic interactions between epithelial cells and immune cells in chips infected with Helicobacter pylori, contributing to a comprehensive understanding of gastric mucosal barrier stability,” explained Professor Park.

The research findings, supported by the Basic Research Laboratory (BRL) research grant from the National Research (NRF), funded by the Ministry of Science and ICT (MSIT), have been published online on July 31 in Advanced Science—a prestigious journal published by Wiley.

These groundbreaking advancements in hsMPS open up new avenues for studying host-microbe interactions, developing therapeutic strategies for gastric infections, and gaining a deeper understanding of gastrointestinal diseases. This innovative biochip technology has the potential to reduce reliance on animal experimentation while providing valuable insights into complex physiological processes within the human stomach.

Journal Reference
Hye-Jin Jeong, Ji-Hyeon Park, Joo H. Kang, et al., “Organoid-based human stomach micro-physiological system to recapitulate the dynamic mucosal defense mechanism,” Adv. Sci., (2023).

END

[Attachments] See images for this press release:
Revolutionary breakthrough: human stomach micro-physiological system unveiled Revolutionary breakthrough: human stomach micro-physiological system unveiled 2 Revolutionary breakthrough: human stomach micro-physiological system unveiled 3

ELSE PRESS RELEASES FROM THIS DATE:

ORNL launches Center for AI Security Research to study AI’s impacts on society, security

ORNL launches Center for AI Security Research to study AI’s impacts on society, security
2023-09-27
The Department of Energy’s Oak Ridge National Laboratory announced the establishment of its Center for AI Security Research, or CAISER, to address threats already present as governments and industries around the world adopt artificial intelligence and take advantage of the benefits it promises in data processing, operational efficiencies and decision-making. In partnership with federal agencies such as the Air Force Research Laboratory’s Information Directorate and the Department of Homeland Security (DHS) Science and Technology Directorate ...

Extreme weight loss: Star sheds unexpected amounts of mass just before going supernova

Extreme weight loss: Star sheds unexpected amounts of mass just before going supernova
2023-09-27
Cambridge, Mass. — A newly discovered nearby supernova whose star ejected up to a full solar mass of material in the year prior to its explosion is challenging the standard theory of stellar evolution. The new observations are giving astronomers insight into what happens in the final year prior to a star’s death and explosion.   SN 2023ixf is a new Type II supernova discovered in May 2023 by amateur astronomer Kōichi Itagaki of Yamagata, Japan shortly after its progenitor, or origin star, ...

Target: BP™ intitiative helps more than 8.6 million Americans with hypertension improve heart health

2023-09-27
DALLAS, September 27, 2023 — The American Heart Association and American Medical Association (AMA) nationally recognized 1,709 health care organizations (HCOs) — 400 more than in 2022 — for their efforts to prioritize control of their patients’ blood pressure (BP), a leading preventable risk factor for heart disease, stroke and premature death. According to the 2022 American Heart Association Statistical Update, nearly half of U.S. adults — 121.5 million ...

Tiny CRISPR tool could help shred viruses

Tiny CRISPR tool could help shred viruses
2023-09-27
HOUSTON – (Sept. 27, 2023) Small and precise: These are the ideal characteristics for CRISPR systems, the Nobel-prize winning technology used to edit nucleic acids like RNA and DNA. Rice University scientists have described in detail the three-dimensional structure of one of the smallest known CRISPR-Cas13 systems used to shred or modify RNA and employed their findings to further engineer the tool to improve its precision. According to a study published in Nature Communications, the molecule works differently than other proteins in the same family. “There are different types of CRISPR systems, and the one ...

Plastic cloud: New study analyzes airborne microplastics in clouds

Plastic cloud: New study analyzes airborne microplastics in clouds
2023-09-27
Plastic particles less than 5 mm in size are called “microplastics.” These tiny bits of plastic are often found in industrial effluents, or form from the degradation of bulkier plastic waste. Research shows that large amounts of microplastics are ingested or inhaled by humans and animals alike and have been detected in multiple organs such as lung, heart, blood, placenta, and feces. Ten million tons of these plastic bits end up in the ocean, released with the ocean spray, and find their way into the atmosphere. This implies that microplastics may have become an essential component of clouds, ...

Winners of the ASTRO-Sumitomo Pharma-Pfizer Alliance new combination therapy challenge announced

2023-09-27
ARLINGTON, Va., September 27, 2023 — The American Society for Radiation Oncology (ASTRO) today announced the three winning research proposals for the 2022 ASTRO-Myovant Sciences (now known as Sumitomo Pharma)-Pfizer Alliance New Combination (Relugolix-Radiation) Therapy Challenge. The Challenge aims to identify research that addresses ways prostate cancer treatments can be improved with the gonadotropin-releasing hormone (GnRH) receptor antagonist relugolix in patients who received radiation therapy. The Challenge invited researchers to propose the study of relugolix in different scenarios: ...

New evidence for sub-network specializations within the Default Mode Network and the Special Role of Facial Movements in Brain Activation and Self-Perception

New evidence for sub-network specializations within the Default Mode Network and the Special Role of Facial Movements in Brain Activation and Self-Perception
2023-09-27
Recent advancements in neuroscience have unveiled new insights into the neural processes responsible for self-referential cognition. This research has brought particular attention to a critical neural network known as the Default Mode Network (DMN), comprising brain regions such as the medial prefrontal cortex (mPFC), posterior cingulate cortex, temporoparietal junction (TPJ), and both lateral and medial temporal lobes. Central to self-related processing, is the information associated with one’s ...

Ultrasound enables gene delivery throughout the brain

Ultrasound enables gene delivery throughout the brain
2023-09-27
HOUSTON – (Sept. 27, 2023) – Rice University researchers tested the safety and feasibility of gene delivery to multiple brain regions using a noninvasive, ultrasound-based technique in rodents, and their findings suggest that the efficiency of gene delivery improves within each targeted site when more sites are opened. Shirin Nouraein, a doctoral student working in the lab of Rice bioengineer Jerzy Szablowski, is the lead author on the study recently published in the journal Gene Therapy. The paper, “Acoustically Targeted Noninvasive Gene Therapy in Large Brain Volumes,” ...

Elevating biogas upgrading performance on renewable aqueous ammonia solution via a novel “membrane method”

Elevating biogas upgrading performance on renewable aqueous ammonia solution via a novel “membrane method”
2023-09-27
Biogas is usually produced by anaerobic digestion of organic waste such as animal manures and straw wastes, which is a typical green renewable energy and can be used as a fuel for power generation and heat production. China has owned large scale of biogas production, with an annual output of about 15 billion m3 biogas, and the biogas development and utilization provide a new choice for coping with the energy crisis. Factually, biogas contains about 60% CH4 and about ...

Golden Goose Award announces 2023 awardees for discoveries in DNA sequencing technique, a bacteria-inspired method that saves crops and chicken pedigree lines

Golden Goose Award announces 2023 awardees for discoveries in DNA sequencing technique, a bacteria-inspired method that saves crops and chicken pedigree lines
2023-09-27
WASHINGTON, D.C. – The Golden Goose Award, which celebrates federally funded research that sounds silly, but ultimately benefits society, has selected five researchers across the fields of biology, agriculture and genomics for their unexpected breakthroughs as 2023 awardees. On September 27, 2023, the American Association for the Advancement of Science (AAAS), the world’s largest multidisciplinary scientific society, will co-host the 12th annual Golden Goose Award ceremony with the Association of American Universities, a founding member of the Golden Goose Award, at the Library ...

LAST 30 PRESS RELEASES:

Heat and heavy metals are changing the way that bees buzz

What’s behind the enormous increase in early-onset gastrointestinal cancers?

Pharmacogenomics expert advances precision medicine for bipolar disorder

Brazilian researcher explores centenarian stem cells for aging insights

Dr. Xuyu Qian's breakthrough analysis of 18 million brain cells advances understanding of human brain development

Gene networks decode human brain architecture from health to glioma

How artificial light at night damages brain health and metabolism

For ultrasound, ultra-strength not always a good thing

Matching your workouts to your personality could make exercising more enjoyable and give you better results

Study shows people perceive biodiversity

Personality type can predict which forms of exercise people enjoy

People can accurately judge biodiversity through sight and sound

People diagnosed with dementia are living longer, global study shows

When domesticated rabbits go feral, new morphologies emerge

Rain events could cause major failure of Waikīkī storm drainage by 2050

Breakthrough in upconversion luminescence research: Uncovering the energy back transfer mechanism

Hidden role of 'cell protector' opens cancer treatment possibilities

How plants build the microbiome they need to survive in a tough environment

Depression due to politics and its quiet danger to democracy addressed in new book 'The Sad Citizen'

International experts and patients unite to help ensure all patients are fully informed before consenting to new surgical procedures

Melting glaciers could trigger more explosive eruptions globally, finds research

Nearly half of U.S. grandchildren live within 10 miles of a grandparent

Study demonstrates low-cost method to remove CO₂ from air using cold temperatures, common materials

Masonic Medical Research Institute (MMRI) welcomes 13 students to prestigious Summer Fellowship program

Mass timber could elevate hospital construction

A nuanced model of soil moisture illuminates plant behavior and climate patterns

$2.6 million NIH grant backs search for genetic cure in deadly heart disease

Pennsylvania’s medical cannabis program changed drastically when anxiety was added as a qualifying condition

1 in 5 overweight adults could be reclassified with obesity according to new framework

Findings of study on how illegally manufactured fentanyl enters U.S. contradict common assumptions, undermining efforts to control supply

[Press-News.org] Revolutionary breakthrough: human stomach micro-physiological system unveiled
The study findings have been published ahead of their official publication in the online version of Advanced Science on July 31, 2023