(Press-News.org) SAN DIEGO, October 1, 2023 — Older adults diagnosed with kidney tumors that are not suitable for surgery may benefit from targeted, high-dose radiation, a new study from Australian and Dutch researchers suggests.
A multi-institutional phase II study – TransTasman Radiation Oncology Group (TROG) FASTRACK II – found 100% local control and cancer-specific survival for longer than three years among patients who were treated non-invasively for inoperable kidney cancer with stereotactic ablative body radiotherapy (SABR). Findings will be presented today at the American Society for Radiation Oncology (ASTRO) Annual Meeting.
Previous smaller, single institution studies showed promise for stereotactic radiation treatments with patients whose kidney tumors are inoperable, yet FASTRACK II is the first study to test SABR’s efficacy in a large, multi-institutional clinical trial.
“Our study demonstrated that a novel treatment delivered in an outpatient setting is able to achieve unprecedented efficacy for patients with inoperable kidney cancer,” said lead study author Shankar Siva, PhD, a radiation oncologist at the Peter MacCallum Cancer Centre and a professor at the University of Melbourne in Australia. “There’s an unmet need for curing this type of cancer, and our findings point to the potential of radiation therapy to address that need.”
As the population ages, the incidence of kidney cancer in older adults is increasing globally, with the greatest increase in people over 70, who also have lower rates of survival. Worldwide, kidney cancer is the sixth most diagnosed cancer in men and 10th in women. Surgery has been the standard of care, either to remove the tumor and surrounding margins or to remove the entire kidney and surrounding tissue.
Yet many older people with renal cell carcinoma have unique challenges that make it difficult to treat them surgically, said Dr. Siva. “People might have other medical issues such as high blood pressure or diabetes, things that place them at higher risk for complications from surgery. They may have tumors in areas that are difficult to operate on, or where surgery may lead to dialysis.”
He said, “our research clearly defines a new population of patients who will benefit from stereotactic radiation. These patients often don’t have other viable treatment options, so we are excited to see that radiation therapy can be effective for them.”
SABR, also known as stereotactic body radiation (SBRT), can shrink or destroy tumors by targeting them directly with high doses of radiation delivered in a small number of outpatient sessions.
In this non-randomized, prospective study, Dr. Siva and his colleagues treated 70 patients who were diagnosed with inoperable, high-risk kidney tumors or who declined surgery for their renal cell cancer. The median patient age was 77 years (range 47-91), and patients had a single lesion.
Participants in the trial were treated with SABR in one or three sessions at seven Australian centers and one in the Netherlands. Treated tumors were relatively large, said Dr. Siva, on average 4.7 centimeters. Patients with tumors smaller than 4 cm received a single fraction of radiation (n=23), and those with tumors larger than 4 cm received three fractions (n=47).
None of the patients experienced a local progression of their kidney cancer during the trial lifetime (median follow-up 43 months), nor did any patients die from cancer. Overall survival was 99% one year after SBRT and 82% at three years. One patient experienced a distant recurrence of their cancer.
Side effects were relatively modest, with no grade 4 or 5 toxicities observed. Seven patients (10%) experienced grade 3 adverse events, most commonly abdominal pain (3 patients). 51 patients (73%) had a grade 1-2 treatment-related event, and 11 patients (16%) experienced no adverse events.
Kidney function was assessed by measuring patients’ estimated glomerular filtration rate (eGFR); the average eGFR declined by 10.8 mLs/min at one year and 14.6 mLs/min at two years after treatment, indicating mild-to-moderate kidney stress. Only one patient required dialysis following treatment. Overall, said Dr. Siva, there was a modest drop in kidney function and that plateaued after two years.
Dr. Siva attributed the high efficacy rate and the ability to preserve kidney function to rigorous quality control, as well as the effectiveness of stereotactic radiation. He also said the findings of this phase II trial justify designing a randomized phase III trial to compare stereotactic radiation to surgery as the primary treatment modality for patients with operable kidney cancer.
“Given a choice between the two, I believe a lot of patients would opt for non-invasive radiation,” he said.
See this study presented:
News Briefing: Tuesday, October 3, 9:00 a.m. Pacific time. Details here. Register here.
Scientific Presentation: Sunday, October 1, 9:50 a.m. Pacific time, San Diego Convention Center. Email firstname.lastname@example.org for access to the livestream or recording.
Abstract Title: TROG 15.03/ANZUP international multicenter phase II trial of focal ablative stereotactic radiotherapy for cancers of the kidney (FASTRACK II) (Abstract 5)
Attribution to the American Society for Radiation Oncology (ASTRO) Annual Meeting is requested in all coverage. View our meeting press kit at www.astro.org/annualmeetingpress.
The American Society for Radiation Oncology (ASTRO) is the largest radiation oncology society in the world, with nearly 10,000 members who are physicians, nurses, biologists, physicists, radiation therapists, dosimetrists and other health care professionals who specialize in treating patients with radiation therapies. Radiation therapy contributes to 40% of global cancer cures, and more than a million Americans receive radiation treatments for cancer each year. For information on radiation therapy, visit RTAnswers.org. To learn more about ASTRO, visit our website and media center and follow us on social media.
High-dose radiation offers new treatment option for older patients with inoperable kidney tumors
Multi-center study achieves durable local control and cancer-specific survival after stereotactic radiation treatment
ELSE PRESS RELEASES FROM THIS DATE:
Liquid biopsies can rapidly detect residual disease following cervical chemoradiation, study finds
SAN DIEGO, October 1, 2023 — Two liquid biopsy tests that look for the presence of human papillomavirus (HPV) in the blood accurately identified patients with a high risk of cervical cancer recurrence after the completion of chemoradiation, a new study confirms. Findings will be presented today at the American Society for Radiation Oncology (ASTRO) Annual Meeting. The study compared two novel tests – a digital polymerase chain reaction (dPCR) test and a sequencing test for genetic material from HPV, the main cause of cervical cancer – and found they were equally effective at identifying residual disease in the blood of patients who ...
Metaphors for human fertilization are evolving, study shows
New Haven, Conn. — In a common metaphor used to describe human fertilization, sperm cells are competitors racing to penetrate a passive egg. But as critics have noted, the description is also a “fairy tale,” rooted in cultural beliefs about masculinity and femininity. A new study by Yale sociologist Rene Almeling provides evidence that this metaphor remains widely used despite the profound shift in recent decades in social and scientific views about gender, sex, and sexuality. But her findings, based ...
Study suggests threshold for type 2 diabetes diagnosis in women under 50 years should be lowered
New research to be presented at this year’s Annual Meeting of the European Association for the Study of Diabetes (EASD) in Hamburg, Germany (2-6 October) and published in the journal Diabetes Therapy suggests that the diagnosis threshold for type 2 diabetes (T2D) should be lowered in women aged under 50 years, since natural blood loss through menstruation could be affecting their blood sugar management. The study is by Dr Adrian Heald, Salford Royal Hospital, UK, and colleagues. Analysis of the national diabetes ...
Synergistic work of cations in anion exchange membranes for OH- transport in fuel cells
Anion exchange membrane fuel cells (AEMFCs) have gained attention in the process of fuel cell development because they operate in alkaline environments, the redox reaction rate at the electrodes is faster, and non-precious metal catalysts such as Ni, Co, and Ag can be used, which reduces the cost of fuel cells. However, the mobility of OH- is only 56.97% of that of H+ under the same conditions, and its stability is poor, so improving the ionic conductivity and mechanical properties of anion exchange membranes (AEM) is the key to the commercialization ...
Hairy polymer balls help get genetic blueprints inside T-cells for blood cancer therapy
Tokyo, Japan – Scientists from Tokyo Metropolitan University have realized a new polymer that can effectively transport plasmid DNA into T-cells during chimeric antigen receptor (CAR) T-cell therapy, a key treatment for blood cancer. Importantly, it can get genes into floating T-cells, not only ones fixed to surfaces. It is stable, non-toxic, and doesn’t use viruses. It outperforms polyion compounds considered a gold standard in the field, paving the way for new therapies. T-cells, or lymphocytes, are a type of white blood cell that helps our immune system fight germs and protect us from disease. Recently, technology has become available that helps reprogram T-cells to fight cancer. ...
Reducing fishing gear could save whales with low impacts to California’s crab fishermen
(Santa Barbara, Calif.) — Sometimes simple solutions are better. It all depends on the nature of the problem. For humpback whales, the problem is the rope connecting a crab trap on the seafloor to the buoy on the surface. And for fishermen, it’s fishery closures caused by whale entanglements. Managing this issue is currently a major item on California’s agenda, and it appears less fishing gear may be the optimal solution. So says a team of researchers led by Christopher Free, at UC Santa Barbara, after modeling the benefits and impacts that several management strategies would have on whales and fishermen. ...
Engineering researchers to study wireless communication and machine learning with NSF grant
A virtual reality (VR) game crashes. A robot rolls dangerously close to the edge of a cliff. An autonomous vehicle speeds toward a pedestrian. Without intelligent control happening every millisecond, accidents can occur. This control can mean applying the brake of an autonomous vehicle to save a life or creating a more user-friendly augmented reality experience. Two professors in the Department of Electrical and Computer Engineering at Texas A&M University are working to enhance and advance the future ...
Wheat's long non-coding RNAs unveiled: A leap in understanding grain development
Wheat is a global staple food and plays a pivotal role in the livelihoods of billions of people. Although long non-coding RNAs (lncRNAs) have been recognized as crucial regulators of numerous biological processes, our knowledge of lncRNAs associated with wheat (Triticum aestivum) grain development remains minimal. Seed Biology published an online paper entitled “A comprehensive atlas of long non-coding RNAs provides insight into grain development in wheat” on 04 September 2023. To ...
New study will examine irritable bowel syndrome as long COVID symptom
Researchers with the ongoing Arizona CoVHORT research study at the University of Arizona Mel and Enid Zuckerman College of Public Health were awarded $3.2 million by the National Institute of Diabetes and Digestive and Kidney Diseases for a five-year study of gastrointestinal symptoms, specifically irritable bowel syndrome, as a condition of long COVID. Led by epidemiologist Kristen Pogreba-Brown, PhD, MPH, the CoVHORT study is a longitudinal research study of COVID-19 and post-COVID conditions. The ...
Department of Energy announces up to $500 million for basic research to advance the frontiers of science
WASHINGTON, D.C. - The U.S. Department of Energy (DOE) today announced up to $500 million in funding for basic research in support of DOE’s clean energy, economic, and national security goals. The funding will advance the priorities of DOE’s Office of Science and its major programs, including Advanced Scientific Computing Research, Basic Energy Sciences, Biological and Environmental Research, Fusion Energy Sciences, High Energy Physics, Nuclear Physics, Isotope R&D and Production, and Accelerator R&D and Production. This funding opportunity will help achieve the Biden Administration’s ...
LAST 30 PRESS RELEASES:
Sacituzumab govitecan plus platinum-based chemotherapy in breast, bladder, and lung carcinomas
Global study unveils "problematic" use of porn
Newly discovered protein prevents DNA triplication
Less ice in the arctic ocean has complex effects on marine ecosystems and ocean productivity
Antarctica’s coasts are becoming less icy
New research shows migrating animals learn by experience
Modeling the origins of life: New evidence for an “RNA World”
Scientists put forth a smarter way to protect a smarter grid
An evolutionary mystery 125 million years in the making
Data science approach to identifying thermal conductivity-related structural factors in amorphous materials
Deciphering the male breast cancer genome
Detection of suicide-related emergencies among children using real-world clinical data: A free webinar from the Brain & Behavior Research Foundation
Editor-in-Chief of Sustainability and Climate Change Madhavi Venkatesan named USA TODAY Woman of the Year for Massachusetts for leading plastic bottle ban efforts
Tests show high-temperature superconducting magnets are ready for fusion
Zika vaccine safe, effective when administered during pregnancy
Firearm ownership is correlated with elevated lead levels in children, study finds
Role of African women and young people in agricultural service provision investigated in new CABI-led study
26th International Conference of the Redox Medicine Society Set for June 2024 in Paris, France
Geologists explore the hidden history of Colorado’s Spanish Peaks
Webb unlocks secrets of one of the most distant galaxies ever seen
3D-printed skin closes wounds and contains hair follicle precursors
Discovered a RNA molecule that helps prevent DNA replication errors
Small and overlooked: Amount of repetitive DNA in blood hints at cancer early
Study determines the original orientations of rocks drilled on Mars
Illinois study: Supporting disease-challenged broiler chickens through nutrition
Communities severed by roads and traffic experience a larger number of collisions in New York City
Study shows new class of antivirals that works against SARS-CoV-2
Cost of direct air carbon capture to remain higher than hoped
Unraveling the mystery of chiton visual systems
Case Western Reserve University-led research team discovers new method to test for oral cancer[Press-News.org] High-dose radiation offers new treatment option for older patients with inoperable kidney tumors
Multi-center study achieves durable local control and cancer-specific survival after stereotactic radiation treatment