Paxlovid and COVID-19 mortality and hospitalization among patients with vulnerability to COVID-19 complications

JAMA Network Open

2023-10-02

(Press-News.org) About The Study: In this study of 6,866 individuals with COVID-19, nirmatrelvir and ritonavir (Paxlovid [Pfizer]) treatment was associated with reduced risk of COVID-19 hospitalization or death in clinically extremely vulnerable individuals, with the greatest benefit observed in severely immunocompromised individuals. No reduction in the primary outcome (death from any cause or emergency hospitalization with COVID-19 within 28 days) was observed in lower-risk individuals, including those age 70 or older without serious comorbidities.

Authors: Colin R. Dormuth, Sc.D., of the University of British Columbia in Vancouver, is the corresponding author.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamanetworkopen.2023.36678)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

# # #

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2023.36678?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=100223

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

END

ELSE PRESS RELEASES FROM THIS DATE:

Discrimination alters brain-gut ‘crosstalk,’ prompting poor food choices and increased health risks

2023-10-02

People frequently exposed to racial or ethnic discrimination may be more susceptible to obesity and related health risks in part because of a stress response that changes biological processes and how we process food cues. These are findings from UCLA researchers conducting what is believed to be the first study directly examining effects of discrimination on responses to different types of food as influenced by the brain-gut-microbiome (BGM) system. The changes appear to increase activation in regions of the brain associated with reward and self-indulgence – like seeking “feel-good” ...

Tablet-based AI app measures multiple behavioral indicators to screen for autism

2023-10-02

DURHAM, N.C. – Researchers at Duke University have demonstrated an app driven by AI that can run on a tablet to accurately screen for autism in children by measuring and weighing a variety of distinct behavioral indicators. Called SenseToKnow, the app delivers scores that evaluate the quality of the data analyzed, the confidence of its results and the probability that the child tested is on the autism spectrum. The results are fully interpretable, meaning that they spell out exactly which of the behavioral indicators led to its conclusions and why. This ability ...

Advanced bladder cancer patients could keep their bladder under new treatment regime, clinical trial shows

2023-10-02

New York, NY (October 2, 2023)—Mount Sinai investigators have developed a new approach for treating invasive bladder cancer without the need for surgical removal of the bladder, according to a study published in Nature Medicine in September. Removing the bladder is currently a standard approach when cancer has invaded the muscle layer of the bladder. In a phase 2 clinical trial that was the first of its kind, doctors found that some patients could be treated with a combination of chemotherapy and immunotherapy without the need to remove their bladder. ...

Plant chloroplasts promise potential therapy for Huntington’s disease

2023-10-02

Researchers at the University of Cologne’s CECAD Cluster of Excellence for Aging Research and the CEPLAS Cluster of Excellence for Plant Sciences have found a promising synthetic plant biology approach for the development of a therapy to treat human neurodegenerative diseases, especially Huntington’s disease. In their publication “In-planta expression of human polyQ-expanded huntingtin fragment reveals mechanisms to prevent disease-related protein aggregation” in Nature Aging, they showed that a synthetic enzyme derived from plants – stromal processing peptidase (SPP) – reduces the clumping of proteins responsible for the pathological changes ...

Contagious cancers in cockles sequenced, showing unexpected instability

2023-10-02

CONTAGIOUS CANCERS IN COCKLES SEQUENCED, SHOWING UNEXPECTED INSTABILITY Transmissible cancers in cockles — marine cancers that can spread through the water — have been sequenced for the first time, unearthing new insight into how these cancers have spread across animal populations for hundreds, possibly thousands, of years. The study, from researchers at the Wellcome Sanger Institute, the CiMUS research centre at the Universidade de Santiago de Compostela in Spain, and collaborators across multiple countries, found that these cockle tumours are highly genetically unstable. The cancer ...

Massive low earth orbit communications satellites could disrupt astronomy

2023-10-02

Observations of the BlueWalker 3 prototype satellite show it is one of the brightest objects in the night sky, outshining all but the brightest stars. Astronomers have raised concerns that without mitigation, groups of large satellites could disrupt our ability to observe the stars from Earth and perform radio astronomy. Several companies are planning ‘constellations’ of satellites – groups of potentially hundreds of satellites that can deliver mobile or broadband services anywhere in the world. However, these satellites need to be in ‘low-Earth’ orbit and can be relatively large, ...

Nerve cells can detect small numbers of things better than large numbers of things

2023-10-02

When two, three or four apples are placed in front of us, we are able to recognize the number of apples very quickly. However, we need significantly more time if there are five or more apples and we often also guess the wrong number. In fact, the brain does actually register smaller numbers of things differently than larger ones. This has been demonstrated in a recent study by the University of Tübingen, University of Bonn and the University Hospital Bonn. The results were published in the magazine Nature ...

Boston Children’s Hospital researchers uncover insights into the developmental trajectory of autism

2023-10-02

In a groundbreaking study published in JAMA Pediatrics on October 2, 2023, researchers at Boston Children’s Hospital shed new light on the evolving nature of Autism Spectrum Disorder (ASD) diagnoses in early childhood. Diagnosing ASD at a young age is important for early intervention and treatment, but this new study suggests that not all kids continue to meet the criteria for ASD as they get older. The team found that 37% of children diagnosed with ASD as toddlers no longer meet the criteria for ASD around the age of six. Children with lower adaptive skills—essential everyday abilities encompassing communication, self-care, and decision-making—tend ...

Sustainable protection of rapidly subsiding coastlines with mangroves

2023-10-02

Vulnerable coastlines Unfortunately, precisely in these rural densely populated Asian regions, mangroves have in the past been cleared to free up land for other uses such as aquaculture. This has made these coasts vulnerable to rapid erosion. Restoring mangroves seems a logical solution to reverse this process and protect these densely populated coastlines. However, this requires understanding if mangroves can cope with extreme rates of relative sea level rises, as experienced in these subsiding areas. Since 2015 NIOZ researcher Celine van Bijsterveldt visited Indonesia regularly during her studies and her Phd. ...

Boreal and temperate forests now main global carbon sinks

2023-10-02

Using a new analysis method for satellite images, an international research team, coordinated by the French Alternative Energies and Atomic Energy Commission (CEA) and INRAE, mapped for the first time annual changes in global forest biomass between 2010 and 2019. Researchers discovered that boreal and temperate forests have become the main global carbon sinks. Tropical forests, which are older and degraded by deforestation, fire and drought, are nearly carbon neutral. The findings, published in Nature Geoscience, highlight the importance of accounting for young forests and forest ...

Paxlovid and COVID-19 mortality and hospitalization among patients with vulnerability to COVID-19 complications

ELSE PRESS RELEASES FROM THIS DATE:

LAST 30 PRESS RELEASES: