Innovative research aims to improve wound healing and cancer therapy
Freiburg researcher Priscilla Briquez receives ERC Starting Grant for innovative approach to protein engineering
2023-10-27
(Press-News.org)
Jun.-Prof. Dr. Priscilla Briquez, junior professor at the Department of General and Visceral Surgery at the Freiburg University Medical Center and member of the Medical Faculty at the University of Freiburg, has received a European Research Council (ERC) Starting Grant from the European Commission. Her DRESSCODE project will receive a total of 1.5 million euros funding for five years. The project focuses on modifying proteins and developing new disease therapies.
“This support is a major opportunity for me to put together my own team and drive forward my research,” says Briquez. The focus of the project is on equipping protein cell membranes with therapeutic receptors. This produces cells which can perform specific healing functions, such as targeted bonding to medicines or pathogens. “The research project opens up new, significant opportunities for both regenerative medicine and cancer immunotherapy,” says Prof. Dr. Lutz Hein, Dean of the Medical Faculty of the University of Freiburg.
Innovations for wound healing and cancer immunotherapy
In the field of regenerative medicine, Briquez’s research approach can specifically alter the vascular endothelial growth factor (VEGF) receptor-2. This promotes the formation of blood vessels in chronic wounds and assists wound healing. In connection with cancer immunotherapy the project is researching the development of chimeric antigen receptors (CAR) on T-cells. These are receptors that are placed on immune cells in order to identify and attack cancer cells.
Briquez gained her PhD in 2016 at the Ecole Polytechnique Federale of Lausanne (EPFL), where she investigated the development of therapeutic proteins and biomaterials for wound healing. After that she was a postdoc at the Pritzker School of Molecular Engineering of the University of Chicago. There, she devoted herself to the field of molecular immunoengineering and cancer immunotherapy, before moving to the Department of General and Visceral Surgery at the Freiburg University Medical Center in 2021 where she was appointed junior professor.
With its Starting Grant funding line the ERC supports junior researchers who have already done outstanding work and who have the potential to assume a leading role in research.
Contact:
Corporate Communications
Freiburg University Medical Center
Tel. +49 761 270-84830
email: kommunikation@uniklinik-freiburg.de
University and Science Communication
University of Freiburg
Tel. +49 761 203-4302
email: kommunikation@zv.uni-freiburg.de
END
[Attachments] See images for this press release:
ELSE PRESS RELEASES FROM THIS DATE:
2023-10-27
Despite rising global mobility, the state of migrant and refugee health data in European health systems is a concern, a new study shows. The analysis by an international coalition of universities, UN organizations, government representatives, and European institutions published in the journal The Lancet Regional Health Europe reveals that coverage of migrant and refugee data remains inconsistent and of suboptimal quality. According to the study this issue is not due to a lack of knowledge or technological resources ...
2023-10-27
WASHINGTON (October 27, 2023) – Boys with Duchenne muscular dystrophy (DMD) have a clinically proven, new treatment option with the Food and Drug Administration’s approval Thursday of vamorolone, a steroidal-type, anti-inflammatory drug developed based on research performed at Children’s National Hospital.
Created by ReveraGen BioPharma Inc., vamorolone has a molecular structure similar to traditional corticosteroids, which are currently used to treat DMD. Yet its structure was found to be chemically different enough to reduce unwanted side effects, including brittle bones and reduced stature. Nearly two decades ago, ReveraGen leaders – President and ...
2023-10-27
Researchers who are working to find alternatives to lithium-ion batteries have turned their attention to potassium-ion batteries. Potassium is an abundant resource and the technology functions in much the same way as lithium-ion batteries, but these batteries have not been developed at a large scale because the ionic radius causes problems in energy storage and substandard electrochemical performance.
To solve this problem, researchers are considering NiCo2Se4, a bimetallic selenide, to create sphere-shaped electrodes. The spheres are constructed with NiCo2Se4 nanotubes, which improve ...
2023-10-27
COLUMBIA, Mo. -- Childhood trauma is a key risk factor for future substance use disorder, overdose, and suicide. This is particularly problematic in rural areas where children experience higher rates of adverse childhood experiences (ACEs). ACEs are commonly defined as physical and emotional abuse and neglect, sexual abuse, parental separation or divorce, intimate partner violence, and having household members with serious mental illness, substance use disorder, or a history of incarceration.
Now, a three-year, U.S. Department of Agriculture (USDA) grant awarded to the University of Missouri will help virtually train various members of the workforce — ...
2023-10-27
Proteins are key to all processes in our cells and understanding their functions and regulation is of major importance.
“For many years, we have known that nearly all human proteins are modified by a specific chemical group, but its functional impact has remained undefined”, says professor Thomas Arnesen at the Department of Biomedicine, University of Bergen.
He explains:
“One of the most common protein modifications in human cells is N-terminal acetylation, which is an addition of a small chemical group (acetyl) at the starting tip (N-terminus) of a protein. The ...
2023-10-27
Researchers have discovered a protein that seals plant roots to regulate the uptake of nutrients and water from the soil, the discovery could help develop climate proof crops that require less water and chemical fertilizers.
Researchers from the University of Nottingham identified new components of the lignin barrier in plant roots and the specific function of dirigent proteins (DPs), located in the root endodermis that control water and nutrient uptake. Their findings have been published today in Science Direct.
Plant roots function by absorbing ...
2023-10-27
Research on the trillions of microorganisms that make up a person’s microbiome can lead to medical breakthroughs to treat diseases like inflammatory bowel syndrome and diabetes. According to Alyssa Bader, a Tsimshian Assistant Professor in the Department of Anthropology at McGill University, microbiome samples from Indigenous communities have the potential to further Western medicine, but those same communities often have been excluded from the research process and may miss out on the benefits that result from their contributions to science. ...
2023-10-27
LOS ANGELES — An international Phase 3 clinical trial found that metastatic colorectal cancer patients with a rare genetic tumor mutation called KRAS G12C experienced superior progression-free survival rates compared to standard of care when offered a combination treatment of KRAS inhibitor sotorasib and monoclonal antibody panitumumab. City of Hope, one of the largest cancer research and treatment organizations in the United States, was a participating site and a City of Hope researcher is the lead author of the The New England Journal of Medicine study published this week.
Standard ...
2023-10-27
A research team has synthesized a new polyoxometalate-based metal-organic complex that they then tested as a catalyst for the oxidation reactions of various sulfides. They found that the complex possesses excellent catalytic performance, good reusability, and structural stability.
The team’s work is published in the journal Polyoxometalates on October 19, 2023.
Scientists in many fields have explored the selective oxidation of sulfides to sulfoxides. Sulfoxides are organic compounds that contain sulfur and oxygen. These sulfoxides are high value-added chemicals in pharmaceuticals, agrochemistry, ...
2023-10-27
Sunscreen usage is climbing, but so are melanoma and skin cancer rates: this, researchers say, is the sunscreen paradox.
“The problem is that people use sunscreen as a ‘permission slip’ to tan,” said Dr. Ivan Litvinov, an Associate Professor in the Department of Medicine and Chair of the Dermatology Division at McGill University and co-author with Dr. Sandra Peláez, Dr. Richie Jeremian and Dr. Pingxing Xie of two recent studies that explore the sunscreen paradox.
“People think they are protected from skin cancer ...
LAST 30 PRESS RELEASES:
[Press-News.org] Innovative research aims to improve wound healing and cancer therapy
Freiburg researcher Priscilla Briquez receives ERC Starting Grant for innovative approach to protein engineering