COVID-19 hospitalization in solid organ transplant recipients on immunosuppressive therapy

JAMA Network Open

2023-11-07

(Press-News.org) About The Study: The findings of this study suggest that maintenance immunosuppressive drugs are associated with an increased risk of COVID-19 hospitalization in solid organ transplant recipients. These results should be considered by clinicians treating transplant recipients and may help inform epidemic-related decisions for this population in the future.

Authors: Epiphane Kolla, M.D., M.P.H., of French National Health Insurance in Saint-Denis, France, is the corresponding author.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi: 10.1001/jamanetworkopen.2023.42006)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

# # #

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2023.42006?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=110723

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

END

ELSE PRESS RELEASES FROM THIS DATE:

Presentation and outcomes of adults with overdose-related out-of-hospital cardiac arrest

2023-11-07

About The Study: In a population-based study of 6,790 adult patients with emergency medical services–treated out-of-hospital cardiac arrest (OHCA) from a U.S. metropolitan system, the incidence of overdose related out-of-hospital cardiac arrest increased significantly from 2015 to 2021. The greatest increase was observed among patients with a combined stimulant-opioid OHCA. Presentation and outcome differed according to the drug-specific profile. The combination of increasing incidence and lower survival among patients with an opioid-stimulant OHCA supports prevention and treatment initiatives ...

Africa’s dangerous air pollution levels are a global problem, says new research

2023-11-07

A new report in Nature Geoscience has brought to light the challenge of air pollution levels in Africa and why international action is needed to combat it. Over the last 50 years African nations have suffered from rapidly deteriorating air quality, making their cities some of the most polluted in the world. Particulate matter concentration levels are now five to ten levels greater than that recommended by the World Health Organisation, with the situation predicted to worsen as populations grow and industrialization accelerates. However, far too little has been ...

Body changes up to eight years before inflammatory bowel disease diagnosis

2023-11-07

Francis Crick Institute press release Under strict embargo: 16:00hrs GMT Tuesday 7 November 2023 Peer reviewed Observational study People Body changes up to eight years before inflammatory bowel disease diagnosis Researchers at the Francis Crick Institute and Aalborg University in Copenhagen have shown that changes can be detected in blood tests up to eight years before a diagnosis of Crohn’s disease and up to three years before a diagnosis of ulcerative colitis. This means the beginnings of inflammatory bowel diseases start a long time before symptoms occur, and in the future may provide an opportunity for doctors to take preventative ...

When dads are feeling a bit depressed or anxious, how do kids fare?

2023-11-07

Many parents experience stress, anxiety, and depressive symptoms throughout their lives, particularly during times of transition, such as pregnancy and children’s entry into school. Studies have generally found that high levels of anxiety and depression in parents are linked to poorer behavioural and cognitive outcomes in children. A team of researchers led by Tina Montreuil, Associate Professor in McGill’s Department of Educational and Counselling Psychology and Scientist in the Child Health and Human ...

Screening sharply improves lung cancer long-term survival

2023-11-07

OAK BROOK, Ill. – Diagnosing early-stage lung cancer with low-dose CT screening dramatically improves the long-term survival rate of cancer patients, according to a large-scale, 20-year international study published today in Radiology, a journal of the Radiological Society of North America (RSNA). The results show that patients diagnosed with lung cancer by low-dose CT screening have a 20-year survival rate of 81%. If diagnosed in the earliest Stage I, long-term survival was 95%. “It is the first time that 20-year survival rates ...

Lung cancer screening dramatically increases long-term survival rate

2023-11-07

New York, NY (November 7, 2023) — Diagnosing early-stage lung cancer with low-dose computed tomography (CT) screening drastically improves its cure rate measured over a 20-year period, according to a large-scale international study by Mount Sinai researchers published in Radiology. The results show that patients diagnosed with lung cancer via CT screening have a 20-year survival rate—an approximation of the cure rate—of 81 percent. Among the 1,257 participants diagnosed with lung cancer, 81 percent ...

New strategy may halt tumors' aggressive response to glucose deprivation

2023-11-07

BACKGROUND One of the hallmarks of cancer cell development is its dependence on sugar, especially glucose, to grow and divide. Scientists have long been studying how to restrict or block this process that promotes tumor growth, called glycolysis, from happening as a possible effective strategy against cancer. Previously, researchers from the UCLA Health Jonsson Comprehensive Cancer Center identified a specific protein sodium glucose transporter 2, or SGLT2, as a mechanism that lung cancer cells can utilize to obtain glucose. Drugs that inhibit SGLT2 are already FDA approved for other conditions and the UCLA team found these drugs could also delay the development ...

Giles Robinson, MD, named director of the Neuro-Oncology Division at St. Jude Children’s Research Hospital

2023-11-07

St. Jude Children’s Research Hospital today announced Giles Robinson, M.D., has assumed the role of director for the Department of Oncology’s Division of Neuro-Oncology. He has also become co-leader of the Neurobiology and Brain Tumor Program within the St. Jude Comprehensive Cancer Center. These combined units comprise one of the largest clinical brain tumor programs in North America. “Dr. Robinson has been an exemplary member of St. Jude since joining as a hematology/oncology fellow in 2007,” said Julie R. Park, M.D., Department of Oncology ...

MD Anderson and Jazz Pharmaceuticals announce five-year collaboration to evaluate zanidatamab in HER2-expressing cancers

2023-11-07

HOUSTON and DUBLIN ― The University of Texas MD Anderson Cancer Center and Jazz Pharmaceuticals plc today announced a five-year strategic research collaboration agreement to evaluate zanidatamab, Jazz’s investigational HER2-targeted bispecific antibody, in multiple HER2-expressing cancers. The collaboration will combine MD Anderson’s translational medicine and clinical research expertise with Jazz’s expanding oncology drug development capabilities to investigate the potential of zanidatamab as monotherapy and in combination with other treatments for patients with different tumor types and stages. This includes its possible applicability ...

An ammonia trail to exoplanets

2023-11-07

They reveal the origin of wine, the age of bones and fossils, and they serve as diagnostic tools in medicine. Isotopes and isotopologues – molecules that differ only in the composition of their isotopes – also play an increasingly important role in astronomy. For example, the ratio of carbon-12 (12C) to carbon-13 (13C) isotopes in the atmosphere of an exoplanet allows scientists to infer the distance at which the exoplanet orbits its central star. Until now, 12C and 13C bound in carbon monoxide were the only isotopologues that could be measured in the atmosphere of an exoplanet. Now a team of researchers has succeeded in detecting ammonia isotopologues ...

LAST 30 PRESS RELEASES:

Detecting early-stage cancers with a new blood test measuring epigenetic instability

Night owl or early bird? Study finds sleep categories aren’t that simple

Psychological therapies for children who speak English as an additional language can become “lost in translation”, study warns

Bat virome evolution in Indochina Peninsula reveals cross-species origins of porcine epidemic diarrhea virus and regional surveillance gaps

How a fridge could unlock modern dairy cattle breeding in the developing world

CHEST® Critical Care added to Web of Science Emerging Sources Citation Index

[Press-News.org] COVID-19 hospitalization in solid organ transplant recipients on immunosuppressive therapy
JAMA Network Open