(Press-News.org) In patients with systemic sclerosis (SSc), a rare connective tissue disease, interstitial lung disease contributes to 35 percent of deaths. Published recently in the American Journal of Respiratory and Critical Care Medicine, the latest American Thoracic Society Clinical Practice Guideline makes a number of recommendations. One recommendation expands antifibrotic treatment to all patients with systemic sclerosis associated with ILD (SSc-ILD), not just those with progressive disease.
Watch the explainer video.
Lead guidelines chair and editor, Ganesh Raghu, M.D., ATSF, noted the timeliness of the recommendations given the many immune modulating agents clinicians already use to treat connective tissue diseases, including SSc. “The need to provide evidence-based clinical practice guideline was evident,” he said.
It was with this in mind that the 24-member international expert panel (that included pulmonologists, rheumatologists, methodologists and patients with SSc) convened. Using the thorough, evidence-based Grading of Recommendations, Assessment, Development and Evaluation or GRADE framework, the expert panel made the following recommendations and suggestions for treating patients with SSc-ILD:
1.We recommend using mycophenolate to treat patients with SSc-ILD (strong recommendation, very low-quality evidence).
2.We suggest using the following medications to treat patients with SSc-ILD:
i : cyclophosphamide (conditional recommendation, low- quality evidence).
ii : nintedanib (conditional recommendation, very low-quality evidence).
iii: rituximab (conditional recommendation, very low-quality evidence).
iv: tocilizumab (conditional recommendation, very low-quality evidence).
v: the combination of nintedanib plus mycophenolate (conditional recommendation, very low-quality evidence).
3. We recommend further research into the safety and efficacy of pirfenidone alone or in combination with mycophenolate to treat patients with SSc-ILD.
Regarding treatment with antifibrotics like nintedanib and pirfenidone, “We emphasize the importance of the shared decision process with patients and physicians, especially for the recommendations that are conditional,” added Dr. Raghu.
To read the latest clinical practice guideline on systemic sclerosis-associated interstitial lung disease in its entirety, visit us online.
For ATS guideline implementation tools and derivatives, go here.
To learn about clinical trials recruiting patients with SSc-ILD, visit the ATS Clinical Trials Resources page. *The ATS does not endorse any trial listed.
END
Systemic sclerosis-associated interstitial lung disease focus of latest clinical practice guideline
The new American Thoracic Society guideline provides evidence to use specific immune modulating and antifibrotic medications to treat all patients with SSc-ILD, not just those with progressive disease
2023-11-08
[Attachments] See images for this press release:
ELSE PRESS RELEASES FROM THIS DATE:
Study confirms the use of a new biomarker for predicting non-lymphocytic lesions, including germinoma, in patients with central diabetes insipidus
2023-11-08
Central diabetes insipidus (CDI), a rare condition involving the destruction or degeneration of neurons of the hypothalamic-posterior pituitary in the brain, has several likely underlying clinical causes. Patients with CDI experience excessive thirst and excessive urine production, owing to the decreased secretion of AVP. Moreover, in children and young adults with CDI, a malignant tumor known as a 'germinoma' may develop later in life. The diagnosis of these tumors is challenging, because biopsy in intracranial lesions is difficult.
Lymphocytic infundibulo-neurohypophysitis (LINH) or ...
Anesthesia blocks sensation by cutting off communication within the cortex
2023-11-08
General anesthesia evokes a dual mystery: How does it disrupt consciousness, including sensory perception, and what might that say about the nature of consciousness. A new study led by researchers at The Picower Institute for Learning and Memory at MIT provides evidence in animals that consciousness depends on properly synchronized communication across the brain’s cortex and that the anesthetic drug propofol cancels sensory processing by cutting it off.
In the Journal of Cognitive Neuroscience, researchers report clear evidence that in anesthetized animals, ...
Genetics of nearby healthy tissue may help catch lung cancer’s return
2023-11-08
Genetic information collected from seemingly healthy tissue near lung tumors may be a better predictor of whether cancer will come back after treatment than analysis of the tumors themselves, according to new research led by NYU Langone Health and its Perlmutter Cancer Center.
The new study focuses on lung adenocarcinoma, a cancer that forms in alveolar epithelial cells and accounts for about a third of all lung cancers in the United States, according to the U.S. Centers for Disease Control and Prevention. Most patients are cured if tumors are surgically removed early in the disease’s progression, but residual ...
Scientists engineer potent immune cells for ‘off-the-shelf’ cancer immunotherapy
2023-11-08
UCLA scientists have developed a new method to engineer more powerful immune cells that can potentially be used for “off-the-shelf” cell therapy to treat challenging cancers.
“Off-the-shelf” cell therapy, also known as allogenic therapy, uses immune cells derived from healthy donors instead of patients. The approach can bring cell therapies, like chimeric antigen receptor (CAR) T cell therapy, to more patients in a timelier manner, which is one of the major barriers in getting these life-saving treatments to patients.
“Time is often of the essence when it comes to treating people with advanced cancers,” said Lili Yang, associate professor ...
Extracellular vesicles captured using sustainable wood celluose-based nanofiber sheets may identify and improve cancer treatment
2023-11-08
A research team in Japan, led by Nagoya University’s Akira Yokoi, has developed an innovative technique using cellulose nanofiber (CNF) sheets derived from wood cellulose to capture extracellular vesicles (EVs) from fluid samples and even organs during surgery. EVs are small structures from cancerous cells that play a crucial role in cell-to-cell communication. Extracting and analyzing EVs using this new technology has the potential to revolutionize early cancer diagnosis and open the door to personalized medicine. The researchers published their findings in Nature Communications.
Cancer is notorious for its poor prognosis and in many cases goes undetected until its ...
Researchers identify brain network that is uniquely activated through injection vs. oral drug use
2023-11-08
Results from a new clinical trial suggest that a group of brain regions known as the “salience network” is activated after a drug is taken intravenously, but not when that same drug is taken orally. When drugs enter the brain quickly, such as through injection or smoking, they are more addictive than when they enter the brain more slowly, such as when they are taken orally. However, the brain circuits underlying these differences are not well understood. This study offers new information that helps explain what may be causing this difference.
The study was published in Nature Communications and led by researchers at the National Institute on Drug Abuse (NIDA) and the National ...
Genes, cells, and embryos in development and evolution: Pere Alberch, 25 years on
2023-11-08
The last 40 years have witnessed a deep transformation in our views of animal development. From seeing development a multicellular black box where over time a mass of cells acquires shape to form organs and tissues, we now have a detailed account of this process in terms of gene expression, multicellular activity, and morphogenesis.
This new point of view has raised questions about the relationships between genes, cells, and organisms. These questions are impacting our thinking about evolution, ...
Rapid high-dose buprenorphine treatment strategy reduces opioid withdrawal in individuals using fentanyl
2023-11-08
Buprenorphine is a medication approved for pain and opioid dependence. New findings published in The American Journal on Addictions indicate that a transmucosal dose (which dissolves in the mouth) of buprenorphine followed by an injection of extended-release buprenorphine (BUP‐XR) may be an effective treatment for individuals with opioid use disorder who use fentanyl.
The results come from a recent secondary analysis of an open-label study in which 24 participants received a single 4 mg dose of transmucosal buprenorphine followed by an injection ...
Do allergic conditions increase the risk of developing Long-COVID after SARS-CoV-2 infection?
2023-11-08
In an analysis of published prospective studies of people of all ages with confirmed SARS-CoV-2 infection who were followed for at least 12 months, pre-existing allergic conditions were linked to higher risks of experiencing long-term symptoms associated with COVID-19, or Long-COVID.
The analysis, which is published in Clinical & Experimental Allergy, identified 13 relevant studies (with a total of 9,967 participants) published between January 1, 2020 and January 19, 2023.
Although the data as a whole from the studies suggested that individuals with asthma or rhinitis might be at increased risk of Long-COVID after SARS-CoV-2 ...
Does being a caregiver affect older women’s longevity?
2023-11-08
In an analysis published in the Journal of the American Geriatrics Society that included older US women, caregiving was associated with a lower risk of death over an average follow-up of 17.5 years.
In the analysis of 158,987 women aged 50–79 years when enrolled in the Women’s Health Initiative (a long-term national health study), 31.8% of women died during follow-up, and women who reported being a caregiver over 2 assessments 10 years apart had a 9% lower risk of dying from any cause compared with non-caregivers. Caregiving was also associated with lower risks of death from cardiovascular disease ...
LAST 30 PRESS RELEASES:
AI finds undiagnosed liver disease in early stages
The American Society of Tropical Medicine and Hygiene and the Bill & Melinda Gates Foundation announce new research fellowship in malaria genomics in honor of professor Dominic Kwiatkowski
Excessive screen time linked to early puberty and accelerated bone growth
First nationwide study discovers link between delayed puberty in boys and increased hospital visits
Traditional Mayan practices have long promoted unique levels of family harmony. But what effect is globalization having?
New microfluidic device reveals how the shape of a tumour can predict a cancer’s aggressiveness
Speech Accessibility Project partners with The Matthew Foundation, Massachusetts Down Syndrome Congress
Mass General Brigham researchers find too much sitting hurts the heart
New study shows how salmonella tricks gut defenses to cause infection
Study challenges assumptions about how tuberculosis bacteria grow
NASA Goddard Lidar team receives Center Innovation Award for Advancements
Can AI improve plant-based meats?
How microbes create the most toxic form of mercury
‘Walk this Way’: FSU researchers’ model explains how ants create trails to multiple food sources
A new CNIC study describes a mechanism whereby cells respond to mechanical signals from their surroundings
Study uncovers earliest evidence of humans using fire to shape the landscape of Tasmania
Researchers uncover Achilles heel of antibiotic-resistant bacteria
Scientists uncover earliest evidence of fire use to manage Tasmanian landscape
Interpreting population mean treatment effects in the Kansas City Cardiomyopathy Questionnaire
Targeting carbohydrate metabolism in colorectal cancer: Synergy of therapies
Stress makes mice’s memories less specific
Research finds no significant negative impact of repealing a Depression-era law allowing companies to pay workers with disabilities below minimum wage
Resilience index needed to keep us within planet’s ‘safe operating space’
How stress is fundamentally changing our memories
Time in nature benefits children with mental health difficulties: study
In vitro model enables study of age-specific responses to COVID mRNA vaccines
Sitting too long can harm heart health, even for active people
International cancer organizations present collaborative work during oncology event in China
One or many? Exploring the population groups of the largest animal on Earth
ETRI-F&U Credit Information Co., Ltd., opens a new path for AI-based professional consultation
[Press-News.org] Systemic sclerosis-associated interstitial lung disease focus of latest clinical practice guidelineThe new American Thoracic Society guideline provides evidence to use specific immune modulating and antifibrotic medications to treat all patients with SSc-ILD, not just those with progressive disease