(Press-News.org) A panel of international experts representing the World Health Organization’s Guideline Development Group has updated its guidance on treatments for patients with covid-19.
The new recommendations published by The BMJ are part of a living guideline, developed by the World Health Organization with the methodological support of MAGIC Evidence Ecosystem Foundation, to provide up to date, trustworthy guidance on the management of covid-19 and help doctors make better decisions with their patients.
The guidance incorporates the latest clinical trial evidence for existing and new covid-19 therapies and takes account of evidence relating to safety, prognosis, resources, access, and equity issues, as well as patient values and preferences.
The updates include:
Distinct risk categories to help doctors more accurately assess whether an individual is at high, moderate, or low risk of hospital admission and tailor treatment accordingly.
A new treatment benefit threshold of 1.5% (down from 6%) reduction in the risk of hospital admission. This reflects the lower baseline risk for most patients with non-severe covid-19 as well as more safety evidence and wider availability of therapies.
A recommendation to use the antiviral drug nirmatrelvir-ritonavir in patients with non-severe covid-19 at high and moderate risk of hospital admission.
A recommendation against use of the antiviral drugs remdesivir and molnupiravir for patients with non-severe covid-19 at moderate and low risk of hospital admission (treatment is suggested for patients at high risk of admission).
A recommendation against use of a new antiviral (VV116) for patients with covid-19 except in clinical trials, regardless of illness severity.
A strong recommendation against the use of ivermectin for patients with non-severe covid-19 (advice against use of ivermectin in patients with severe or critical covid-19, except in clinical trials, still exists).
The experts say the new recommendations reflect changes in the virulence and transmissibility of circulating SARS-CoV-2 variants and sub-variants, along with changes in immunity related to global vaccinations, which have led to lower baseline risks of severe illness and death for most patients with non-severe covid-19.
They acknowledge that there are still uncertainties around covid-19 therapeutics and emerging evidence and say these recommendations need to be used in light of these uncertainties.
An interactive decision support tool is available to accompany this guidance.
END
WHO updates its guidance on treatments for COVID-19
New recommendations reflect the evolving nature of the virus and the changing role of covid-19 therapies
2023-11-10
ELSE PRESS RELEASES FROM THIS DATE:
UTHealth Houston researchers awarded $2.6 million NIH grant to study molecular pathways and potential strategies for treatment of myocardial ischemia and reperfusion injury
2023-11-10
A four-year, $2.6 million grant to study circadian rhythm and novel therapies to protect the heart during a heart attack or cardiac surgery has been awarded to UTHealth Houston by the National Heart, Lung, and Blood Institute, part of the National Institutes of Health.
Principal investigator Holger Eltzschig, MD, PhD, professor, and co-investigator Wei Ruan, MD, PhD, assistant professor, from the Department of Anesthesiology, Critical Care and Pain Medicine at McGovern Medical School at UTHealth Houston, are studying translational, pharmacologic, and interventional strategies targeting ...
What human diseases can teach us about the immune system
2023-11-10
The immune system is a crucial part of our survival, regularly fending off wide-ranging attacks on the body, both internal and external. Unsurprisingly, the elegant defense system that protects us from viruses, bacterial infections, cancer, and other threats is immensely complicated. Each time it mounts a response, it must quickly and carefully orchestrate communication across vast numbers of cells and molecules.
Jennifer Oyler-Yaniv is working to figure out how, exactly, the immune system does this — and when and why it fails.
“There's always the next question, the next ...
Texas A&M researchers contribute to international project studying coronavirus transmission in humans, cattle
2023-11-10
Researchers from the Texas A&M School of Veterinary Medicine and Biomedical Sciences’ (VMBS) Veterinary Education, Research, and Outreach (VERO) program have joined an international team studying how coronaviruses are spread and whether an individual’s microbiome (the collection of microbes living in or on the body) might impact that transmission.
Coronaviruses are a family of viruses that can cause a variety of diseases in many species, from the common cold and severe acute respiratory syndrome (SARS) in people, to diarrhea in calves and respiratory disease in ...
NASA’s Webb, Hubble telescopes combine to create most colorful view of universe
2023-11-10
Astronomers once again have combined the observational powers of NASA’s James Webb Space Telescope and Hubble Space Telescope to create one of the most detailed and colorful portraits of the cosmos, just in time for the holiday season.
The new image, dubbed the Christmas Tree Galaxy Cluster by the research team that includes Texas A&M University astronomer Dr. Lifan Wang, combines visible light from Hubble with infrared light detected by Webb to showcase MACS0416, a galaxy cluster about 4.3 billion light-years from Earth. Because the cluster is able to magnify the light from more distant background galaxies through a phenomenon known as gravitational ...
Ten 2023 postdoctoral fellowships in aging research awarded by the Glenn Foundation for Medical Research and AFAR
2023-11-10
NEW YORK, NY and SANTA BARBARA, CA — The American Federation for Aging Research (AFAR) and the Glenn Foundation for Medical Research are pleased to announce the recipients of the 2023 Glenn Foundation for Medical Research Postdoctoral Fellowships in Aging Research. This program supports postdoctoral fellowswho study basic research mechanisms of aging and/or translational findings that have potential to directly benefit human health.
Selected through a rigorous review process, ten, one-year, $75,000 Postdoctoral ...
Mystery solved: how hummingbirds fly through gaps that are too small
2023-11-10
Soaring, wings outstretched, many birds sail through the air unhindered. However, species that dine on fruit, seeds and nectar must negotiate tiny gaps in cluttered foliage to secure a feast. To pass through apertures, many birds pull in their wings, folding them closer to their bodies. However, some of the most manoeuvrable aviators, hummingbirds, have lost the ability to fold their wings at the wrists and elbows. ‘Unless hummingbirds implement distinctive strategies to transit narrow apertures, they may be unable to enter gaps less than one wingspan wide’, ...
Hummingbirds' unique sideways flutter gets them through small apertures
2023-11-10
Most birds that flit through dense, leafy forests have a strategy for maneuvering through tight windows in the vegetation — they bend their wings at the wrist or elbow and barrel through.
But hummingbirds can't bend their wing bones during flight, so how do they transit the gaps between leaves and tangled branches?
A study published today in the Journal of Experimental Biology shows that hummingbirds have evolved their own unique strategies — two of them, in fact. These strategies have not been reported before, likely because hummers maneuver too ...
National analysis suggests that potentially serious complications occur in 1 in 18 procedures under the care of an anaesthetist
2023-11-10
New survey data from the 7th National Audit Project of the Royal College of Anaesthetists (NAP7) published in Anaesthesia (the journal of the Association of Anaesthetists) shows that potentially serious complications occur in one in 18 procedures under the care of an anaesthetist.
The risk factors associated with these potentially serious complications include very young age (babies); comorbidities; being male; increased frailty; the urgency and extent of surgery; and surgery taking place at night and/or at weekends.
This paper has been produced by a team of authors across ...
Study finds that laser epilation reduces risk of recurrence of pilonidal disease
2023-11-09
Laser epilation, commonly known as laser hair removal, reduced the risk of recurrence in patients with pilonidal disease, an inflammatory, painful, and sometimes chronic or recurring condition, according to research conducted by Peter C. Minneci, M.D., Chair of Surgery at Nemours Children’s Health, Delaware Valley, and published in JAMA Surgery.
Pilonidal disease occurs when cysts form between the buttocks. It is believed to be an inflammatory reaction to hair or debris that gets caught in the crease of the buttocks. The disease occurs in 26 to 100 per 100,000 people and is most common in adolescents and young ...
The U.S. Supreme Court restricted abortion rights and public support for abortion increased
2023-11-09
A new study examining the effects of the U.S. Supreme Court ruling on Dobbs v. Jackson Women's Health Organization on June 24, 2022, which overturned Roe v. Wade's constitutional protection of abortion rights, finds that the American public's support for abortion increased after the decision.
The findings were published today in Nature Behaviour.
"Our results show the extent to which the Supreme Court is out of step with the American public," says co-author Sean Westwood, an associate professor of government at Dartmouth and director of the Polarization Research Lab.
The study's findings were based on a large, three-wave survey before the leak ...
LAST 30 PRESS RELEASES:
Exercise as an anti-ageing intervention to avoid detrimental impact of mental fatigue
UMass Amherst Nursing Professor Emerita honored as ‘Living Legend’
New guidelines aim to improve cystic fibrosis screening
Picky eaters by day, buffet by night: Butterfly, moth diets sync to plant aromas
Pennington Biomedical’s Dr. Leanne Redman honored with the E. V. McCollum Award from the American Society for Nutrition
CCNY physicists uncover electronic interactions mediated via spin waves
Researchers’ 3D-printing formula may transform future of foam
Nurture more important than nature for robotic hand
Drug-delivering aptamers target leukemia stem cells for one-two knockout punch
New study finds that over 95% of sponsored influencer posts on Twitter were not disclosed
New sea grant report helps great lakes fish farmers navigate aquaculture regulations
Strain “trick” improves perovskite solar cells’ efficiency
How GPS helps older drivers stay on the roads
Estrogen and progesterone stimulate the body to make opioids
Dancing with the cells – how acoustically levitating a diamond led to a breakthrough in biotech automation
Machine learning helps construct an evolutionary timeline of bacteria
Cellular regulator of mRNA vaccine revealed... offering new therapeutic options
Animal behavioral diversity at risk in the face of declining biodiversity
Finding their way: GPS ignites independence in older adult drivers
Antibiotic resistance among key bacterial species plateaus over time
‘Some insects are declining but what’s happening to the other 99%?’
Powerful new software platform could reshape biomedical research by making data analysis more accessible
Revealing capillaries and cells in living organs with ultrasound
American College of Physicians awards $260,000 in grants to address equity challenges in obesity care
Researchers from MARE ULisboa discover that the European catfish, an invasive species in Portugal, has a prolonged breeding season, enhancing its invasive potential
Rakesh K. Jain, PhD, FAACR, honored with the 2025 AACR Award for Lifetime Achievement in Cancer Research
Solar cells made of moon dust could power future space exploration
Deporting immigrants may further shrink the health care workforce
Border region emergency medical services in migrant emergency care
Resident physician intentions regarding unionization
[Press-News.org] WHO updates its guidance on treatments for COVID-19New recommendations reflect the evolving nature of the virus and the changing role of covid-19 therapies