Prescription opioid exposure during pregnancy and risk of spontaneous preterm delivery

JAMA Network Open

2024-02-14

(Press-News.org) About The Study: In this study of 251,000 pregnant patients with Tennessee Medicaid and without opioid use disorder, a positive association was found between total prescription opioid dose dispensed and the odds of spontaneous preterm birth. These findings support guidance to minimize opioid exposure during pregnancy and prescribe the lowest dose necessary.

Authors: Sarah S. Osmundson, M.D., M.S., of the Vanderbilt University Medical Center in Nashville, is the corresponding author.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamanetworkopen.2023.55990)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

# # #

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2023.55990?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=021424

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

END

ELSE PRESS RELEASES FROM THIS DATE:

Researchers characterize the immune landscape in cancer

2024-02-14

New York, NY [February 14, 2024]—Researchers from the Icahn School of Medicine at Mount Sinai, in collaboration with the Clinical Proteomic Tumor Analysis Consortium of the National Institutes of Health, The University of Texas MD Anderson Cancer Center, Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, and others, have unveiled a detailed understanding of immune responses in cancer, marking a significant development in the field. The findings were published in the February ...

Altermagnetism proves its place on the magnetic family tree

2024-02-14

There is now a new addition to the magnetic family: thanks to experiments at the Swiss Light Source SLS, researchers have proved the existence of altermagnetism. The experimental discovery of this new branch of magnetism is reported in Nature and signifies new fundamental physics, with major implications for spintronics. Magnetism is a lot more than just things that stick to the fridge. This understanding came with the discovery of antiferromagnets nearly a century ago. Since then, the family of magnetic materials has been divided into two fundamental phases: the ferromagnetic branch known for several millennia and the antiferromagnetic branch. The experimental proof of a third branch of ...

A “quantum leap” at room temperature

2024-02-14

In the realm of quantum mechanics, the ability to observe and control quantum phenomena at room temperature has long been elusive, especially on a large or “macroscopic” scale. Traditionally, such observations have been confined to environments near absolute zero, where quantum effects are easier to detect. But the requirement for extreme cold has been a major hurdle, limiting practical applications of quantum technologies. Now, a study led by Tobias J. Kippenberg and Nils Johan Engelsen at EPFL, redefines the boundaries of what’s ...

Amazon rainforest at the threshold: loss of forest worsens climate change

2024-02-14

The Amazon rainforest could approach a tipping point, which could lead to a large-scale collapse with serious implications for the global climate system. A new Nature study by an international research team including scientists from the Potsdam Institute for Climate Impact research (PIK) reveals that up to 47 percent of the Amazonian forest is threatened and identifies climatic and land-use thresholds that should not be breached to keep the Amazon resilient. “The Southeastern Amazon has already shifted from a carbon sink to a source –meaning that the current amount of human pressure is too high for the region to maintain its status as a rainforest over the long term. But ...

Researchers uncover mechanisms behind enigmatic shapes of nuclei

2024-02-14

Nearly 150 years ago, scientists discovered that specialized blood cells serve a vital role in immune system protection against infection and illness. Certain groups of these white blood cells, now known as neutrophils, feature a nucleus that is structured strikingly different than most nuclei. The majority of cells feature round- or oval-shaped nuclei that are rigid, but neutrophils differ in that their nuclei adopt multiple lobular structures akin to that of flower petal arrangements. These unique nuclear shapes permit neutrophils to travel all over the body to identify and combat invading ...

Online images may be turning back the clock on gender bias

2024-02-14

A picture is worth a thousand words, as the saying goes, and research has shown that the human brain does indeed better retain information from images than from text. These days, we are taking in more visual content than ever as we peruse picture-packed news sites and social media platforms. And much of that visual content, according to new Berkeley Haas research published in the journal Nature, is reinforcing powerful gender stereotypes. Through a series of experiments, observations, and the help of large language models, professors Douglas Guilbeault and Solène Delecourt found that female and male gender associations are more extreme among Google Images than within text ...

Smoking has long-term effects on the immune system

2024-02-14

Like other factors such as age, sex and genetics, smoking has a major impact on immune responses. This is the finding recently made by a team of scientists at the Institut Pasteur using the Milieu Intérieur cohort of 1,000 healthy volunteers, established to understand variability in immune responses. In addition to its short-term impact on immunity, smoking also has long-term consequences. For many years after they have quit the habit, smokers are left with effects on some of their bodies' defense mechanisms acquired while smoking. These findings, which for the first time reveal a long-term memory of the effects of smoking ...

Male fertility gene discovery reveals path to success for sperm

2024-02-14

Discovery of a pair of genes that work in perfect harmony to protect male fertility, could provide new insights into some unexplained cases of the most severe form of infertility, research suggests. Genetic analysis of cases of male infertility revealed that rare mutations in a gene, known as SPOCD1, disrupts the formation of healthy sperm during the earliest stages of their development. The gene was also found to work in partnership with a previously unknown gene, C19orf84, to protect the early-stage precursors to sperm, known as germ cells, from damage. The discovery of the essential role of these ...

Genome sequencing unveils mutational impacts of radiation on mammalian cells

2024-02-14

Recent release of the waste water from Japan's Fukushima nuclear disaster stirred apprehension regarding the health implications of radiation exposure. Classified as a Group 1 carcinogen, ionizing radiation has long been associated with various cancers and genetic disorders, as evidenced by survivors and descendants of atomic bombings and the Chernobyl disaster. Despite much smaller amount, we remain consistently exposed to low levels of radiation in everyday life and medical procedures. Radiation, whether in the form of high-energy particles or electromagnetic waves, is conventionally known to break our cellular DNA, leading to cancer ...

WashU awarded up to $20 million to create portable device to scan for eye diseases

2024-02-14

In the United States, more than one-fourth of adults over age 40 have an eye disease, including glaucoma, cataracts or age-related macular degeneration, or a chronic health condition that affects the eyes, such as diabetic retinopathy. These conditions are a strain on an individual’s health as well as on the health-care system, yet early diagnosis and management can help to prevent more than 90% of severe vision loss. Chao Zhou, a professor of biomedical engineering in the McKelvey School of Engineering at Washington University in St. Louis, has been working to improve optical coherence tomography (OCT) systems that can conduct high-resolution imaging of the ...

Prescription opioid exposure during pregnancy and risk of spontaneous preterm delivery

ELSE PRESS RELEASES FROM THIS DATE:

LAST 30 PRESS RELEASES: