PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Impact of onset time, number, type, and sequence of extrahepatic organ failure on prognosis of acute-on-chronic liver failure

2024-03-08
(Press-News.org)

Background and Aims

The impact of the characteristics of extrahepatic organ failure (EHOF) including the onset time, number, type, and sequence on the prognosis of acute-on-chronic liver failure (ACLF) patients remains unknown. This study aimed to identify the association between the characteristics of EHOF and the prognosis of ACLF patients.

 

Methods

ACLF subjects enrolled at six hospitals in China were included in the analysis. The risk of mortality based on the characteristics of EHOF was evaluated. Survival of study groups was compared by Kaplan–Meier analysis and log-rank tests.

 

Results

A total of 736 patients with ACLF were included. EHOF was observed in 402 patients (54.6%), of which 295 (73.4%) developed single EHOF (SEHOF) and 107 (26.6%) developed multiple EHOF (MEHOF). The most commonly observed EHOF was coagulation failure (47.0%), followed by renal (13.0%), brain (4.9%), respiratory (4.3%), and circulatory (2.3%) failure. Survival analysis found that MEHOF or SEHOF patients with brain failure had a worse prognosis. However, no significant outcome was found in the analysis of the effect of onset time and sequence of failed organs on prognosis. Patients were further divided into three risk subgroups by the EHOF characteristics. Kaplan–Meier analysis showed that risk stratification resulted in the differentiation of patients with different risks of mortality both in the training and validation cohorts.

 

Conclusions

The mortality of ACLF patients was determined by the number and type, but not the onset time and sequence of EHOF. Risk stratification applicable to clinical practice was established.

 

https://www.xiahepublishing.com/2310-8819/JCTH-2023-00379

 

The study was recently published in the Journal of Clinical and Translational Hepatology.

Follow us on X: https://twitter.com/xiahepublishing

Follow us on LinkedIn: https://www.linkedin.com/company/xia&he-publishing-inc/

END



ELSE PRESS RELEASES FROM THIS DATE:

High-tech 'paint' could spare patients repeated surgeries

High-tech paint could spare patients repeated surgeries
2024-03-08
UVA Health researchers have received $2.8 million to advance their development of a high-tech way to save heart and dialysis patients from the need for multiple surgeries. Researchers Lian-Wang Guo, PhD, and K. Craig Kent, MD, are pioneering a quick and gentle technique to “paint” tiny nanoparticles on transplanted veins to prevent the veins from becoming clogged in the future. This type of blockage often causes cardiovascular and dialysis patients to require repeated surgeries; approximately half of all heart ...

Unveiling the role of FOXO1 in vascular development and transcriptional dynamics in endothelial cells

Unveiling the role of FOXO1 in vascular development and transcriptional dynamics in endothelial cells
2024-03-08
The human vascular system, a complex network of blood vessels, plays an essential role in maintaining health. Understanding the molecular mechanisms underlying vascular development is important for tackling age-related disorders. The Forkhead box O (FOXO1) transcription factor is crucial in processes related to aging, cellular metabolism, and apoptosis. Despite its significance, the comprehensive regulation of FOXO1 across the genome in endothelial cells (EC) has not been investigated.   In a new paper published in iScience in February 2024, a research team from Kumamoto University ...

Call for papers| Special Issue on advanced robotics and tissue engineering

Call for papers| Special Issue on advanced robotics and tissue engineering
2024-03-08
Scope For decades, robotic systems have played a pivotal role in nurturing the growth of tissue-engineered constructs in controlled environments through the provision of mechanical stimulation. The importance of physical stresses in tissue maturation is not only intuitive from our own bodily experiences but is also supported by a growing body of mechanotransduction research. However, experimental studies have predominantly remained confined to basic in vitro setups, hampering our ability to produce functional grafts that can translate into clinical practice. Emerging evidence suggests that replicating physiological stresses more faithfully could further enhance the functionality of tissue ...

Optimizing boosters: How COVID mRNA vaccines reshape immune memory after each dose

Optimizing boosters: How COVID mRNA vaccines reshape immune memory after each dose
2024-03-08
mRNA vaccines developed against the spike glycoprotein of severe acute respiratory syndrome type 2 coronavirus (SARS-CoV-2), displayed remarkable efficiency in combating coronavirus 19 (COVID-19). These vaccines work by triggering both cellular and humoral immune responses against the spike protein of the virus. Cellular immunity may play a more protective role than humoral immunity to variants of concerns (VOC) against SARS-CoV-2, as it targets the conserved regions of spike protein and possibly cross-reacts with other variants.   Since a single spike epitope is recognized by multiple T-cell clones, the ...

Mapping the future’s sweet spot for clean energy and biodiversity

Mapping the future’s sweet spot for clean energy and biodiversity
2024-03-08
Climate change is driving both the loss of biodiversity and the need for clean, renewable energy. It is also shifting where species are expected to live in the future. Yet these realities are rarely considered together. Where can clean energy projects be built without impacting the future habitat ranges of threatened and endangered species? A study from the University of California, Davis, examines this question by overlaying renewable energy siting maps with the ranges of two species in the southwestern United States: the iconic and climate-vulnerable ...

Brain waves travel in one direction when memories are made and the opposite when recalled

Brain waves travel in one direction when memories are made and the opposite when recalled
2024-03-08
In the space of just a few seconds, a person walking down a city block might check their phone, yawn, worry about making rent, and adjust their path to avoid a puddle. The smell from a food cart could suddenly conjure a memory from childhood, or they could notice a rat eating a slice of pizza and store the image as a new memory.    For most people, shifting through behaviors quickly and seamlessly is a mundane part of everyday life.    For neuroscientists, it’s one of the brain’s most remarkable capabilities. That’s because different activities require the brain to use different combinations of its many regions and billions of neurons. How ...

Lack of focus doesn’t equal lack of intelligence — it’s proof of an intricate brain

2024-03-08
By Gretchen Schrafft, Science Communications Specialist, Robert J. & Nancy D. Carney Institute for Brain Science PROVIDENCE, R.I. [Brown University] — Imagine a busy restaurant: dishes clattering, music playing, people talking loudly over one another. It’s a wonder that anyone in that kind of environment can focus enough to have a conversation. A new study by researchers at Brown University’s Carney Institute for Brain Science provides some of the most detailed insights yet into the brain mechanisms that help people pay attention amid such distraction, as well as what’s ...

Many type 2 diabetes patients lack potentially life-saving knowledge about their disease

2024-03-08
The body's inability to produce enough insulin or use it effectively often results in type 2 diabetes (T2D), a chronic disease affecting hundreds of millions of people around the globe. Disease management is crucial to avoid negative long-term outcomes, such as limb amputation or heart disease. To counteract adverse consequences, it is crucial that patients have good knowledge about the day-to-day management of the disease.  A team of researchers in Portugal has now assessed how many patients – both insulin-treated and not insulin-treated – have this crucial knowledge about T2D. They published their findings in Frontiers in Public Health. “Our main motivation ...

Small class sizes not better for pupils’ grades or resilience, says study

2024-03-08
Smaller class sizes in schools are failing to increase the resilience of children from low-income families, according to a study published in the peer-reviewed International Journal of Science Education. Data on more than 2,700 disadvantaged secondary (high) school students shows that minimizing pupil numbers in classrooms does not lead to better grades. Reducing class sizes could even decrease the odds of children achieving the best results, say the study authors. The quantity of teachers also does not increase the odds of pupils from the poorest backgrounds achieving academically, despite concerns over staff shortages in schools. Instead, the researchers ...

Two-dimensional bimetallic selenium-containing metal-organic frameworks and their calcinated derivatives as electrocatalysts for overall water splitting

Two-dimensional bimetallic selenium-containing metal-organic frameworks and their calcinated derivatives as electrocatalysts for overall water splitting
2024-03-08
Transition metal selenides have been considered to be a good choice for electrocatalytic water splitting. In addition, Metal-organic frameworks (MOFs) have been used to make catalysts with good electrocatalytic capabilities. Traditionally, the MOF-derived selenides are produced via the self-sacrificing MOF template methods. However, this strategy is high-energy consuming, and it is difficult to precisely control the structure and component homogeneity of the product during pyrolysis. A research group of Wang-ting Lu, Fan Yu, and Yun Zheng ...

LAST 30 PRESS RELEASES:

A third of licensed GPs in England not working in NHS general practice

ChatGPT “thought on the fly” when put through Ancient Greek maths puzzle

Engineers uncover why tiny particles form clusters in turbulent air

GLP-1RA drugs dramatically reduce death and cardiovascular risk in psoriasis patients

Psoriasis linked to increased risk of vision-threatening eye disease, study finds

Reprogramming obesity: New drug from Italian biotech aims to treat the underlying causes of obesity

Type 2 diabetes may accelerate development of multiple chronic diseases, particularly in the early stages, UK Biobank study suggests

Resistance training may improve nerve health, slow aging process, study shows

Common and inexpensive medicine halves the risk of recurrence in patients with colorectal cancer

SwRI-built instruments to monitor, provide advanced warning of space weather events

Breakthrough advances sodium-based battery design

New targeted radiation therapy shows near-complete response in rare sarcoma patients

Does physical frailty contribute to dementia?

Soccer headers and brain health: Study finds changes within folds of the brain

Decoding plants’ language of light

UNC Greensboro study finds ticks carrying Lyme disease moving into western NC

New implant restores blood pressure balance after spinal cord injury

New York City's medical specialist advantage may be an illusion, new NYU Tandon research shows

Could a local anesthetic that doesn’t impair motor function be within reach?

1 in 8 Italian cetacean strandings show evidence of fishery interactions, with bottlenose and striped dolphins most commonly affected, according to analysis across four decades of data and more than 5

In the wild, chimpanzees likely ingest the equivalent of several alcoholic drinks every day

Warming of 2°C intensifies Arctic carbon sink but weakens Alpine sink, study finds

Bronze and Iron Age cultures in the Middle East were committed to wine production

Indian adolescents are mostly starting their periods at an earlier age than 25 years ago

Temporary medical centers in Gaza known as "Medical Points" (MPs) treat an average of 117 people daily with only about 7 staff per MP

Rates of alcohol-induced deaths among the general population nearly doubled from 1999 to 2024

PLOS One study: In adolescent lab animals exposed to cocaine, High-Intensity Interval Training boosts aversion to the drug

Scientists identify four ways our bodies respond to COVID-19 vaccines

Stronger together: A new fusion protein boosts cancer immunotherapy

Hidden brain waves as triggers for post-seizure wandering

[Press-News.org] Impact of onset time, number, type, and sequence of extrahepatic organ failure on prognosis of acute-on-chronic liver failure