PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

A third Covid vaccine dose improves defence for some clinically extremely vulnerable patients

More than half (54%) of ‘non-respondents’ from the initial vaccine course still saw no relevant antibody increase

2024-05-09
(Press-News.org) A major clinical trial has found that an additional COVID 19 vaccine dose led to the majority of clinically extremely vulnerable people mounting defensive antibodies against Covid-19.

 

New research published in The Lancet Rheumatology from the OCTAVE DUO research trial co-led by the University of Birmingham and University of Glasgow found that vaccine boosters led to improved antibody responses among many groups of immunocompromised and immunosuppressed patients.

 

Co-funded by the Government and Blood Cancer UK and supported by the National Institute for Health and Care Research (NIHR), this trial opened in 11 hospitals across the UK and recruited 804 patients across nine disease areas, all of whom had previously mounted low or no immune response from an initial two doses of the vaccines.

 

Among those who mounted a low immune response, 90% patients who received a third vaccine dose went onto develop significant antibody levels.

 

However, more than half (54%) of ‘non-respondents’ from the initial vaccine course still saw no relevant antibody increase. Furthermore, the study found that those with lymphoid disease and chronic renal disease had the worst antibody mounting outcomes from boosters.

 

The OCTAVE DUO study also found:

some drugs reduced antibody response including treatments for autoimmune diseases and cancers – specifically B Cell targeted therapy and antimetabolites. T Cell response was mounted for 80% of all participants, including more than half (55%) of those previously not showing any T Cells after two vaccinations.  

Pamela Kearns, Professor of Clinical Paediatric Oncology and Director of the Institute of Cancer and Genomic Sciences at the University of Birmingham, and a lead investigator of the trial said:

 

“The Covid booster programme has been shown to have an important protective effect for many of the most clinically vulnerable members of society for whom the initial two doses were insufficient. In the OCTAVE DUO study, we tracked those who mounted little or no antibody defences following two initial doses of a vaccine. It is encouraging to see that boosters helped to increase antibody defences 9 in 10 participants who hadn’t previously mounted a defence after two jabs.

 

“However, more than half of those who didn’t respond at all to an initial course of vaccines didn’t develop any antibody defence after boosters. This underscores the need for other protective factors to support the most clinically vulnerable in society and continue to be vigilant against Covid in society.”

 

Professor Iain McInnes, Head of the College of Medical, Veterinary and Life Sciences at the University of Glasgow and Chief Investigator for the OCTAVE Consortium, said:

 

“Our first OCTAVE study revealed a group of patients who may not mount a sufficient immune response following a vaccine dose, which is why the OCTAVE DUO study is so important. For the clinically vulnerable in our society, the vaccine booster programme offers important protection, therefore further understanding of the effectiveness of vaccines in people with immune-mediated inflammatory diseases is extremely important. It is encouraging to see the results of OCTAVE DUO, which provides important answers and reinforces the need to support and protect patients who are more clinically vulnerable.”

END


ELSE PRESS RELEASES FROM THIS DATE:

Inconclusive evidence suggests zinc may slightly shorten common cold

2024-05-09
A new Cochrane review has found that taking zinc may help to reduce the duration of common cold symptoms by about two days, but the evidence is not conclusive and potential benefits must be balanced against side-effects. Since the 1980s, zinc products have been marketed as treatments for the common cold and are particularly popular in the USA. Zinc is an essential mineral naturally found in many foods and plays a role in immune function. Most people in high-income countries get enough zinc through their diets, although aging and some chronic diseases may lead to deficiency. The theory behind zinc-based lozenges, sprays and syrups is that the zinc may interfere ...

Study: Neuropathy very common, underdiagnosed

2024-05-08
EMBARGOED FOR RELEASE UNTIL 4 P.M. ET, WEDNESDAY, MAY 8, 2024 MINNEAPOLIS – Neuropathy, the nerve damage that causes pain and numbness in the feet and hands and can eventually lead to falls, infection and even amputation, is very common and underdiagnosed, according to a study published in the May 8, 2024, online issue of Neurology®, the medical journal of the American Academy of Neurology. “More than one-third of people with neuropathy experience sharp, prickling or shock-like pain, which increases their rates of depression and decreases quality of life,” said study author Melissa ...

Rensselaer Polytechnic Institute announces Reid Wiseman as Bicentennial Commencement Speaker and will award its first posthumous honorary degree to Emily Warren Roebling

Rensselaer Polytechnic Institute announces Reid Wiseman as Bicentennial Commencement Speaker and will award its first posthumous honorary degree to Emily Warren Roebling
2024-05-08
Rensselaer Polytechnic Institute (RPI) today announced two special honorands for its Bicentennial Commencement celebrations. Astronaut and Artemis II Commander Reid Wiseman ’97 will return to RPI as the Bicentennial Commencement Speaker, and Emily Warren Roebling, who led the construction of the Brooklyn Bridge to completion, will receive a posthumous honorary degree, the first to be awarded in the history of RPI. Reid Wiseman ’97 Reid Wiseman ’97, decorated naval aviator, test pilot, and commander of the Artemis II mission — which will ...

Diabetes in youth may increase risk for neurodegenerative disease, like Alzheimer’s disease later in life

2024-05-08
AURORA, Colo. (May 8, 2024) – Young people with diabetes may have a significantly higher risk of developing Alzheimer’s disease later in life, according to a new study by researchers in the Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center at the University of Colorado Anschutz Medical Campus. In the study, published this week in the journal Endocrines, scientists showed the presence of specific blood biomarkers indicating early signs of neurodegeneration and Alzheimer’s ...

Teens who view their homes as more chaotic than their siblings have poorer mental health in adulthood

2024-05-08
Many parents ponder why one of their children seems more emotionally troubled than the others. A new study in the United Kingdom reveals a possible basis for those differences.  Adolescents who view their households as more unstructured, disorganized, or hectic than their siblings develop more mental health and behavioral problems in early adulthood, according to the study. The findings are published in Psychological Science, a journal of the Association for Psychological Science. In research tracking ...

New insight into genesis of spina bifida

New insight into genesis of spina bifida
2024-05-08
A group of researchers at the University of California San Diego School of Medicine led an investigation that offers new insight into the causes of spina bifida, the most common structural disorder of the human nervous system. Work of the group, led by Keng Ioi Vong, Ph.D., and Sangmoon Lee, M.D. Ph.D., both from the laboratory of Joseph G. Gleeson, M.D., at the UC San Diego School of Medicine Department of Neurosciences and the Rady Children’s Institute for Genomic Medicine, reveals the first link between spina bifida and a common chromosomal microdeletion ...

The spread of misinformation varies by topic and by country in Europe

The spread of misinformation varies by topic and by country in Europe
2024-05-08
The eventual prevalence of a piece of misinformation may depend on its topic and the country in which it spreads, with notable differences between the UK, Germany, France and Italy, according to a study published May 8, 2024 in the open-access journal PLOS ONE by Fabiana Zollo from the Ca’ Foscari University of Venice, Italy, and colleagues. This finding suggests that policies to combat misinformation and polarization may need to be context-specific in order to be effective, the authors say. Researchers analyzed ...

Pacific Oyster density has increased up to 32-fold across a decade in some California waters, and coincides with summer seawater temperature increases of 2-4°C

Pacific Oyster density has increased up to 32-fold across a decade in some California waters, and coincides with summer seawater temperature increases of 2-4°C
2024-05-08
Pacific Oyster density has increased up to 32-fold across a decade in some California waters, and coincides with summer seawater temperature increases of 2-4°C ### Article URL:  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0302935 Article Title: Intra-decadal increase in globally-spread Magallana gigas in southern California estuaries Author Countries: USA Funding: “Funding was provided by CSU Fullerton and via subcontracts with Merkel & Associates, Inc. and Port of San Diego to DCZ. Funders had no involvement in the study design or data collection process.” The funders had no role in study design, data collection ...

The EU could mitigate climate change equivalent to 13% of its agricultural greenhouse gas emissions by planting cover crops on bare soil before maize

The EU could mitigate climate change equivalent to 13% of its agricultural greenhouse gas emissions by planting cover crops on bare soil before maize
2024-05-08
The EU could mitigate climate change equivalent to 13% of its agricultural greenhouse gas emissions by planting cover crops on bare soil before maize ### Article URL:  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0302139 Article Title: Cover crops support the climate change mitigation potential of agroecosystems Author Countries: Germany Funding: The research was funded by the German Federal Ministry of Education and Research within the Project "CATCHY", project number: 031B1060C. The funders had no role in study design, data collection and analysis, decision ...

Strengthening CAR-T therapy to work against solid tumors

Strengthening CAR-T therapy to work against solid tumors
2024-05-08
May 8, 2024—(BRONX, NY)—Researchers at the National Cancer Institute-designated Montefiore Einstein Comprehensive Cancer Center (MECCC) have shown that a breakthrough therapy for treating blood cancers can be adapted to treat solid tumors—an advance that could transform cancer treatment. The promising findings, reported today in Science Advances, involve CAR-T cell therapy, which supercharges the immune system to identify and attack cancer cells. “CAR-T cell therapy has revolutionized ...

LAST 30 PRESS RELEASES:

New College of AI, Cyber and Computing launched at UT San Antonio

Collaborative team earns five-year renewal grant from NINDS to continue stroke research

Vitamin K analogues may help transform the treatment of neurodegenerative diseases

Cyclic triaxial tests: Evaluation of liquefaction resistance in chemically treated soils

Uniting the light spectrum on a chip

Hundreds of new bacteria, and two potential antibiotics, found in soil

Smells deceive the brain – are interpreted as taste

New species survival commission fills critical gap in conservation

New conservation committee led by Applied Microbiology International calls on science community to get on board with microbial conservation

Scientists uncover key stabilizing role of small molecules

“Black Hole Stars” could solve JWST riddle of overly massive early galaxies

Mysterious ‘red dots’ in early universe may be ‘black hole star’ atmospheres

A gene mutation found in East Asian people increases liver disease risk by an ‘aldehyde storm’

Artificial intelligence‑assisted conductive hydrogel dressings for refractory wounds monitoring

Scalable fabrication of methylammonium‑free wide‑bandgap perovskite solar cells by blade coating in ambient air

Wearable devices could revolutionize pregnancy monitoring and detect abnormalities

Efficient cation recognition strategies for cationic compounds

US COVID-19 school closures were not cost-effective, but other non-pharmaceutical interventions were, new study finds

Human activities linked to declines of big seeds

North-south autism assessment divide leaves children waiting three years longer 

Want to publish in Nature? Webinar with Prof. Willie Peijnenburg shares insider tips

Cataract surgery on both eyes can be carried out safely and effectively in one go

Personalized brain stimulation shows benefit for depression

AI uncovers hidden rules of some of nature’s toughest protein bonds

Innovative approach helps new mothers get hepatitis C treatment

Identifying the Interactions That Drive Cell Migration in Brain Cancer

ORNL receives 2025 SAMPE Organizational Excellence Award

University of Oklahoma researchers aim to reduce indigenous cancer disparities

Study reveals new evidence, cost savings for common treatments for opioid use disorder in mothers and infants

Research alert: Frequent cannabis users show no driving impairment after two-day break

[Press-News.org] A third Covid vaccine dose improves defence for some clinically extremely vulnerable patients
More than half (54%) of ‘non-respondents’ from the initial vaccine course still saw no relevant antibody increase