PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Branched glycopolymer prodrug-derived nanoassembly combined with a STING agonist activates an immuno-supportive status to boost anti-PD-L1 antibody therapy

2024-05-15
(Press-News.org) https://doi.org/10.1016/j.apsb.2024.02.006

 

This new article publication from Acta Pharmaceutica Sinica B, discusses how branched glycopolymer prodrug-derived nanoassembly combined with a STING agonist activates an immuno-supportive status to boost anti-PD-L1 antibody therapy.

 

Despite the great potential of anti-PD-L1 antibodies for immunotherapy, their low response rate due to an immunosuppressive tumor microenvironment has hampered their application.

 

To address this issue, the authors of this article constructed a cell membrane-coated nanosystem (mB4S) to reverse an immunosuppressive microenvironment to an immuno-supportive one for strengthening the anti-tumor effect. In this system, Epirubicin (EPI) as an immunogenic cell death (ICD) inducer was coupled to a branched glycopolymer via hydrazone bonds and diABZI as a stimulator of interferon genes (STING) agonist was encapsulated into mB4S. After internalization of mB4S, EPI was acidic-responsively released to induce ICD, which was characterized by an increased level of calreticulin (CRT) exposure and enhanced ATP secretion. Meanwhile, diABZI effectively activated the STING pathway.

 

Treatment with mB4S in combination with an anti-PD-L1 antibody elicited potent immune responses by increasing the ratio of matured dendritic cells (DCs) and CD8+ T cells, promoting cytokines secretion, up-regulating M1-like tumor-associated macrophages (TAMs) and down-regulating immunosuppressive myeloid-derived suppressor cells (MDSCs).

 

Therefore, this nanosystem for co-delivery of an ICD inducer and a STING agonist achieved promotion of DCs maturation and CD8+ T cells infiltration, creating an immuno-supportive microenvironment, thus potentiating the therapy effect of the anti-PD-L1 antibody in both 4T1 breast and CT26 colon tumor mice.

 

Keywords: Glycopolymer; Polymer prodrug; Immunogenic cell death; Nanoassembly; Epirubicin; STING pathway; Immuno-supportive microenvironment; Immunotherapy

Graphical Abstract: available at https://ars.els-cdn.com/content/image/1-s2.0-S2211383524000443-ga1.jpg  

A branched glycopolymer-EPI prodrug-derived nanoassembly combined with a STING agonist to remodel an immunosuppressive microenvironment to an immuno-supportive one, thus potentiating the therapy effect of anti-PD-L1 antibodies.

# # # # # #

The Journal of the Institute of Materia Medica, the Chinese Academy of Medical Sciences and the Chinese Pharmaceutical Association.

For more information please visit https://www.journals.elsevier.com/acta-pharmaceutica-sinica-b/

Editorial Board: https://www.journals.elsevier.com/acta-pharmaceutica-sinica-b/editorial-board

 

APSB is available on ScienceDirect (https://www.sciencedirect.com/journal/acta-pharmaceutica-sinica-b).

 

Submissions to APSB may be made using Editorial Manager® (https://www.editorialmanager.com/apsb/default.aspx).

 

CiteScore: 19.4

Impact Factor: 14.5

JIF without self-citation: 13.7

ISSN 2211-3835

 # # # # #

Zhilin Li, Qianfeng Zhang, Zhiqian Li, Long Ren, Dayi Pan, Qiyong Gong, Zhongwei Gu, Hao Cai, Kui Luo, Branched glycopolymer prodrug-derived nanoassembly combined with a STING agonist activates an immuno-supportive status to boost anti-PD-L1 antibody therapy, Acta Pharmaceutica Sinica B, Volume 14, Issue 5, 2024, Pages 2194-2209, ISSN 2211-3835, https://doi.org/10.1016/j.apsb.2024.02.006

END



ELSE PRESS RELEASES FROM THIS DATE:

5S-Heudelotinone alleviates experimental colitis by shaping the immune system and enhancing the intestinal barrier in a gut microbiota-dependent manner

2024-05-15
https://doi.org/10.1016/j.apsb.2024.02.020   This new article publication from Acta Pharmaceutica Sinica B, discusses how 5S-Heudelotinone alleviates experimental colitis by shaping the immune system and enhancing the intestinal barrier in a gut microbiota-dependent manner.   Aberrant changes in the gut microbiota are implicated in many diseases, including inflammatory bowel disease (IBD). Gut microbes produce diverse metabolites that can shape the immune system and impact the intestinal barrier integrity, indicating that microbe-mediated modulation may be a promising strategy for preventing and treating IBD.   Although ...

ALS-linked C9orf72 dipeptide repeats inhibit starvation-induced autophagy through modulating BCL2–BECN1 interaction

2024-05-15
https://doi.org/10.1016/j.apsb.2024.02.004   This new article publication from Acta Pharmaceutica Sinica B, discusses how ALS-linked C9orf72 dipeptide repeats inhibit starvation-induced autophagy through modulating BCL2–BECN1 interaction.   Growing evidence indicate that dysfunction of autophagy contributes to the disease pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two neurodegenerative disorders. The GGGGCC·GGCCCC repeat RNA expansion in chromosome 9 open reading frame 72 (C9orf72) ...

Carbon-capture batteries developed to store renewable energy, help climate

Carbon-capture batteries developed to store renewable energy, help climate
2024-05-15
Researchers at the Department of Energy’s Oak Ridge National Laboratory are developing battery technologies to fight climate change in two ways, by expanding the use of renewable energy and capturing airborne carbon dioxide.  This type of battery stores the renewable energy generated by solar panels or wind turbines. Utilizing this energy when wind and sunlight are unavailable requires an electrochemical reaction that, in ORNL’s new battery formulation, captures carbon dioxide from industrial emissions and converts it to value-added products.   ORNL researchers recently created and tested two different formulations for batteries that ...

From roots to resilience: investigating the vital role of microbes in coastal plant health

From roots to resilience: investigating the vital role of microbes in coastal plant health
2024-05-15
Georgia’s saltwater marshes — living where the land meets the ocean — stretch along the state’s entire 100-mile coastline. These rich ecosystems are largely dominated by just one plant: grass. Known as cordgrass, the plant is an ecosystem engineer, providing habitats for wildlife, naturally cleaning water as it moves from inland to the sea, and holding the shoreline together so it doesn’t collapse. Cordgrass even protects human communities from tidal surges. Understanding how these ...

Q&A: How did the COVID-19 pandemic affect older adults’ technology use?

2024-05-15
The onset of the COVID-19 pandemic changed how nearly everyone mediated their social interactions through technology. Some moved happy hours into video chats. Others delved deeper into social media, or took a step back from it. Millions of people worked or learned through computers. University of Washington researchers took particular interest in how this tech shift affected older adults’ social relationships. The team interviewed 16 older adults in Washington and Oregon, ages 65 to 80, about how their technology ...

Blood pressure drugs more than double bone-fracture risk in nursing home patients

2024-05-15
Records from nearly 30,000 nursing home residents indicate that blood pressure medications more than double the risk of life-threatening bone fractures, according to Rutgers Health research. The authors of the study, which appears in JAMA Internal Medicine, said the increased risk stems from the medications’ tendency to impair balance, particularly when patients first stand up and temporarily experience low blood pressure that deprives the brain of oxygen. Interactions with other drugs and low baseline balance in many nursing home patients compound the problem. “Bone fractures often start nursing home patients on a downward spiral,”  ...

Regenerating worms have genetic control over their algal partners

Regenerating worms have genetic control over their algal partners
2024-05-15
Many organisms are far more complex than just a single species. Humans, for example, are full of a variety of microbes. Some creatures have even more special connections, though. Acoels, unique marine worms that regenerate their bodies after injury, can form symbiotic relationships with photosynthetic algae that live inside them. These collections of symbiotic organisms are called a holobiont, and the ways that they “talk” to each other are something scientists are trying to understand – especially ...

Pre- and post-surgical immunotherapy improves outcomes for patients with operable lung cancer

Pre- and post-surgical immunotherapy improves outcomes for patients with operable lung cancer
2024-05-15
Compared with pre-surgical (neoadjuvant) chemotherapy alone, adding perioperative immunotherapy – given before and after surgery – significantly improved event-free survival (EFS) in patients with resectable early-stage non-small cell lung cancer(NSCLC), according to researchers from The University of Texas MD Anderson Cancer Center. Results from the Phase III CheckMate 77T study were published today in the New England Journal of Medicine. At a median follow-up of 25.4 months, the median EFS with chemotherapy alone was 18.4 months, while the median had not yet ...

'Trojan horse' weight loss drug more effective than available therapies

2024-05-15
“I consider the drugs available on the marked today as the first generation of weight-loss drugs. Now we have developed a new type of weight-loss drug that affects the plasticity of the brain and appears to be highly effective.” So says Associate Professor and Group Leader Christoffer Clemmensen, from the Novo Nordisk Foundation Center for Basic Metabolic Research at the University of Copenhagen, who is senior author of the new study, which has been published in the prestigious scientific journal Nature. In the study, Christoffer Clemmensen and colleagues demonstrate a new use of the weight loss hormone GLP-1. GLP-1 can be used as a ‘Trojan ...

Reduced risk of breast cancer following bariatric surgery in women with hyperinsulinemia

Reduced risk of breast cancer following bariatric surgery in women with hyperinsulinemia
2024-05-15
Bariatric surgery is associated with a reduced risk of breast cancer in women with obesity. These are the findings of a study conducted at the University of Gothenburg. The risk reduction is greatest for those with high blood insulin levels at the time of surgery. The study, published in JAMA Surgery, is based on data from 2,867 women with obesity, half of whom had undergone bariatric surgery at 25 surgical departments. The remaining women, comprising the control group, received standard obesity treatment at 480 healthcare centers. The groups were otherwise comparable in terms of age and body composition. The results show that a total of ...

LAST 30 PRESS RELEASES:

Community partners key to success of vaccine clinic focused on neurodevelopmental conditions

Low-carbon collaborative dual-layer optimization for energy station considering joint electricity and heat demand response

McMaster University researchers uncover potential treatment for rare genetic disorders

The return of protectionism: The impact of the Sino-US trade war

UTokyo and NARO develop new vertical seed distribution trait for soybean breeding

Research into UK’s use of plastic packaging finds households ‘wishcycle’ rather than recycle – risking vast contamination

Vaccine shows promise against aggressive breast cancer

Adverse events affect over 1 in 3 surgery patients, US study finds

Outsourcing adult social care has contributed to England’s care crisis, argue experts

The Lancet: Over 800 million adults living with diabetes, more than half not receiving treatment, global study suggests

New therapeutic approach for severe COVID-19: faster recovery and reduction in mortality

Plugged wells and reduced injection lower induced earthquake rates in Oklahoma

Yin selected as a 2024 American Society of Agronomy Fellow

Long Covid could cost the economy billions every year

Bluetooth technology unlocks urban animal secrets

This nifty AI tool helps neurosurgeons find sneaky cancer cells

Treatment advances, predictive biomarkers stand to improve bladder cancer care

NYC's ride-hailing fee failed to ease Manhattan traffic, new NYU Tandon study reveals

Meteorite contains evidence of liquid water on Mars 742 million years ago

Self-reported screening helped reduce distressing symptoms for pediatric patients with cancer

Which risk factors are linked to having a severe stroke?

Opening borders for workers: Abe’s profound influence on Japan’s immigration regime

How skills from hospitality and tourism can propel careers beyond the industry

Research shows managers of firms handling recalls should review media scrutiny before deciding whether to lobby

New model system for the development of potential active substances used in condensate modifying drugs

How to reduce social media stress by leaning in instead of logging off

Pioneering research shows sea life will struggle to survive future global warming

In 10 seconds, an AI model detects cancerous brain tumor often missed during surgery 

Burden of RSV–associated hospitalizations in US adults, October 2016 to September 2023

Repurposing semaglutide and liraglutide for alcohol use disorder

[Press-News.org] Branched glycopolymer prodrug-derived nanoassembly combined with a STING agonist activates an immuno-supportive status to boost anti-PD-L1 antibody therapy