- Press Release Distribution

New tool may help prioritize high-risk infants for RSV immunization

New tool may help prioritize high-risk infants for RSV immunization
( EMBARGOED UNTIL:  9:39 a.m. PT, May 21, 2024


Session:  C17 – Pediatric Impact of COVID-19 and Other Respiratory Infections
Clinical Prediction Tool for Prioritizing Respiratory Syncytial Virus Prevention Products for High-Risk Infants During Current Limited Availability of Nirsevimab in the United States
Date and Time: Tuesday, May 21, 2024, 9:39 a.m. PT
Location:  San Diego Convention Center, Room 6D (Upper Level)


ATS 2024, San Diego – On the heels of a shortage of nirsevimab for infant respiratory syncytial virus (RSV) lower respiratory tract infection (LRTI) prevention, a new tool may help identify newborns at highest risk for developing serious RSV LRTI, according to research published at the ATS 2024 International Conference.  

“Timely identification of infants at highest risk of RSV-related morbidity is key to prevention,” said lead author Brittney M. Snyder, PhD, assistant professor, Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center. “Our personalized risk prediction tool may have applications in allocating expensive and/or limited immunoprophylaxis (immunization with nirsevimab or palivizumab) to achieve the greatest benefit and in promoting RSV prevention among families with high-risk infants.”

More than half of RSV LRTIs are among healthy, term infants who are generally considered low risk. These infants are, in fact, at risk for requiring intensive care unit -level care, and some may die from their illness. Early immunization with nirsevimab is recommended for all infants by the Centers for Disease Control & Prevention, yet in October 2023 nirsevimab was in short supply and the CDC recommended giving it only to high-risk infants who weren’t eligible for immunization with palivizumab. Both products, which prevent RSV LRTI in newborns and young children, are monoclonal antibodies (nirsevimab is long-acting and only requires one dose, while palivizumab is short-acting and requires monthly injections during RSV season).

In the population-based study by Dr. Snyder and colleagues including children insured by the Tennessee Medicaid Program, the researchers assessed infants who did not receive RSV immunoprophylaxis in the first year of life.  They gathered demographic and clinical data from administrative health care encounters and linked birth certificates.  “To predict whether these infants developed severe RSV LRTI requiring ICU admission during the first year of life, we developed a multivariable logistic regression model. The model includes demographic and clinical variables collected at or shortly after birth–19 variables in all, such as prenatal smoking, delivery method, maternal age and assisted breathing (ventilation) during birth hospitalization,” said lead biostatistician Tebeb Gebretsadik, MPH, Department of Biostatistics, Vanderbilt University Medical Center.

Among 429,365 infants in the study, 713 had severe RSV LRTI requiring ICU admission. The tool had good predictive accuracy and internal validation that indicated a good fit.

“Our objective was to develop a personalized tool for use in all newborns using readily available birth and postnatal data to predict risk of RSV LRTI requiring ICU admission, useful for prioritizing RSV prevention products with limited availability,” said Principal Investigator Tina V. Hartert, MD, MPH, professor of medicine and pediatrics at Vanderbilt University Medical Center. Even though the recent nirsevimab shortage has, fortunately, eased up, it is not known whether shortages will occur in the future. “This tool may be particularly helpful in prioritizing which infants should be immunized during times of limited availability of RSV prevention medicines. Using the tool to identify if their infant is at high risk for RSV infection requiring ICU care may also persuade vaccine-hesitant families to accept RSV immunoprophylaxis, by showing them their newborn is at high risk,” she added.

“To ensure compatibility with nirsevimab and maternal vaccination, our tool was developed for use in all infants,” concluded co-author Niek Achten, MD, postdoctoral fellow in pediatrics, Erasmus University Medical Center, Rotterdam, Netherlands, who imagined the need for such a tool. “In addition to use in the United States during times of limited availability, our tool may prove useful in countries with budgetary constraints needing to prioritize administration to the highest risk infants.”

The authors note that next steps to ensure optimal usefulness include validation of the tool in external populations, further cost-effectiveness analyses and decision curve analyses.  






Dacia Morris                                                               Craig Boerner

Director of Communications & Marketing            Asst. Director, Media Director, Natl. News Director

American Thoracic Society                                       Vanderbilt University Medical Center                                    




[Attachments] See images for this press release:
New tool may help prioritize high-risk infants for RSV immunization New tool may help prioritize high-risk infants for RSV immunization 2


Drug helps reprogram macrophage immune cells, suppress prostate and bladder tumor growth

Drug helps reprogram macrophage immune cells, suppress prostate and bladder tumor growth
FOR IMMEDIATE RELEASE A novel therapy that reprograms immune cells to promote antitumor activity helped shrink hard-to-treat prostate and bladder cancers in mice, according to research from the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy and Johns Hopkins Drug Discovery. The study was published online May 3 in the journal Cancer Immunology Research, a journal of the American Association for Cancer Research. Immunotherapies that help the immune system recognize and fight tumors have revolutionized care for many types of cancer. However, ...

Green infrastructure plans need to consider historical racial inequalities, say researchers

Green infrastructure plans need to consider historical racial inequalities, say researchers
CHAMPAIGN, Ill. — Urban planners increasingly are interested in green infrastructure projects for the health and climate benefits they bring to cities. But without attention to historical development patterns and existing power structures, such projects may not benefit all residents equally and may exacerbate social and racial inequalities, says a group of researchers and practitioners of nature-based solutions for urban areas. The researchers outlined their recommendations for a justice-oriented approach to urban greening projects in a paper published in the journal ...

ENDO 2024 press conferences to highlight male birth control, anti-obesity medications

BOSTON—Researchers will delve into emerging research in diabetes, obesity, reproductive health and other aspects of hormone health during the Endocrine Society’s ENDO 2024 news conferences June 1-4. The Society also will share its vitamin D Clinical Practice Guideline publicly for the first time during a news conference on Monday, June 3. Reporters will have an opportunity to hear directly from members of the guideline development panel. Other press conferences will feature select abstracts that are being presented at ENDO 2024, the Endocrine Society’s ...

Highly sensitive fiber optic gyroscope senses rotational ground motion around active volcano

Highly sensitive fiber optic gyroscope senses rotational ground motion around active volcano
WASHINGTON — Researchers have built a prototype fiber optic gyroscope for high resolution, real-time monitoring of ground rotations caused by earthquakes in the active volcanic area of Campi Flegrei in Naples, Italy. A better understanding of the seismic activity in this highly populated area could improve risk assessment and might lead to improved early warning systems. “When seismic activity occurs, the Earth’s surface experiences both linear and rotational movements,” said research team leader Saverio Avino from the Consiglio Nazionale delle Ricerche Istituto Nazionale di Ottica (CNR-INO) ...

Research reveals endurance exercise training impacts biological molecules

As part of an ongoing national research effort to better understand how physical activity improves health and prevents disease, seven University of Colorado Department of Medicine faculty members contributed to an article recently published in Nature, an international journal of science.  The paper, “Temporal dynamics of the multi-omic response to endurance exercise training,” discusses how eight weeks of endurance exercise training affected male and female young adult rats. The researchers found that all bodily tissues that were tested ...

Does managing oxidative stress hold the key to effectively treating Alzheimer’s disease

Amsterdam, May 21, 2024 – The number of people suffering from Alzheimer’s disease (AD) is expected to reach 100 million by 2050, but there is still no effective therapy. Leading researchers from around the world assess how oxidative stress (OS) may trigger AD and consider potential therapeutic targets and neuroprotective drugs to manage the disease in a collection of articles in a special supplement to the Journal of Alzheimer’s Disease, published by IOS Press. AD is the most common type of dementia and involves areas of ...

Warming climate intensifies flash droughts worldwide

Warming climate intensifies flash droughts worldwide
WASHINGTON — Sudden, severe dry spells known as flash droughts are rising in intensity around the world, with a notable exception in mountainous Central Asia, where flash drought extent is shrinking, according to new research. Heat and changes to precipitation patterns caused by a warming climate are driving these trends, the study found. Flash droughts arrive suddenly, within weeks, hitting communities that are often not prepared and causing lasting impact. They are an emerging concern for water and food security. The new study is the first to apply a systematic, quantitative approach to the global incidence of flash drought, mapping hotspots and ...

US public health preparedness and response to highly pathogenic avian influenza A(H5N1) viruses

About The Study: Public health authorities in nearly all states and territories surveyed reported the ability to monitor and test persons exposed to highly pathogenic avian influenza (HPAI) A(H5N1) virus. However, jurisdictions varied in their capacity to monitor exposed persons, in recommendations for use of antivirals, and in potential use of H5N1 vaccines, if available, among first responders.  Corresponding Author: To contact the corresponding author, Noah Kojima, M.D., email To access the embargoed study: Visit our For The Media website at this ...

DRI to host AWE+ wildfire summit

Today, DRI, one of our nation’s leading applied environmental research institutes, together with its Foundation, announced a new global initiative with the first in a series of summits. The event will be held at Encore Las Vegas from August 21-23, 2024. The AWE+ initiative will promote an Adaptable World Environment of strong, resilient communities in a climate shifting world. AWE+ 2024 - Wildfire Recovery and Resilience: Working Across Silos to Drive Solutions - is a global call-to-action for communities ...

MD Anderson Research Highlights for May 21, 2024

HOUSTON ― The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back. Recent developments at MD Anderson offer insights into biomarkers that predict immunotherapy responses, a possible treatment strategy for patients with LKB1-deficient cancers, therapeutic targets to prevent acute myeloid leukemia (AML) progression ...


Discovery of spontaneous inflow and outflow states of high-temperature plasma by energetic ions

Tax the rich, say a majority of adults across 17 G20 countries surveyed

Semaglutide leads to greater weight loss in women than men with HF, improves HF symptoms in both sexes

12.5, the 1st Impact Factor of COMMTR released!

Circadian clock impact on cluster headaches funded by $2.4M NIH grant for UTHealth Houston research

Study identifies first drug therapy for sleep apnea

How old is your bone marrow?

Boosting biodiversity without hurting local economies

ChatGPT is biased against resumes with credentials that imply a disability — but it can improve

Simple test for flu could improve diagnosis and surveillance

UT Health San Antonio researcher awarded five-year, $2.53 million NIH grant to study alcohol-assisted liver disease

Giving pre-med students hands-on clinical training

CAMH research suggests potential targets for prevention and early identification of psychotic disorders

Mapping the heart to prevent damage caused by a heart attack

Study challenges popular idea that Easter islanders committed ‘ecocide’

Chilling discovery: Study reveals evolution of human cold and menthol sensing protein, offering hope for future non-addictive pain therapies.

Elena Beccalli, new rector of Università Cattolica del Sacro Cuore, takes office on 1st July

Pacific Northwest Research Institute uncovers hidden DNA mechanisms of rare genetic diseases

Empowering older adults: Wearable tech made easier with personalized support

Pennington Biomedical researchers partner on award-winning Long Covid study

Cooling ‘blood oranges’ could make them even healthier – a bonus for consumers

Body image and overall health found important to the sexual health of older gay men, according to new studies

Lab-grown muscles reveal mysteries of rare muscle diseases

Primary hepatic angiosarcoma: Treatment options for a rare tumor

Research finds causal evidence tying cerebral small-vessel disease to Alzheimer’s, dementia

Navigating the Pyrocene: Recent Cell Press papers on managing fire risk

Restoring the Great Salt Lake would have environmental justice as well as ecological benefits

Cannabis, tobacco use, and COVID-19 outcomes

A 5:2 intermittent fasting meal replacement diet and glycemic control for adults with diabetes

Scientists document self-propelling oxygen decline in the oceans

[] New tool may help prioritize high-risk infants for RSV immunization