(Press-News.org) The decision to undergo surgery can be complicated for people living with dementia, not only due to limited decision-making capabilities, but also because participation in rehabilitation afterward is imperative to surgery success.
A new study by investigators from Brigham and Women’s Hospital, a founding member of the Mass General Brigham healthcare system, looked at hip fracture treatment outcomes in patients with dementia to see how they did when treated surgically versus non-surgically to help inform healthcare decision making. The team found that those treated surgically experienced lower odds of death than those treated non-surgically and that this benefit was only seen in patients who had fractures of the head and neck of the femur versus other locations of the hip. Their results are published in the journal JAMA Network Open.
“Our goal is to better understand surgical decision making for patients that have dementia. And we know that that hip fractures are common among older adults,” said first author Rachel Adler, ScD, RD a research scientist at the Center for Surgery and Public Health at Brigham and Women’s Hospital. “This study provides valuable insight on outcomes that may be important to patients and caregivers when making the decision about whether or not to have surgery.”
In this retrospective cohort study, the researchers looked at data from 56,209 Medicare patients with dementia who were living in their communities, not in a facility, and who experienced new hip fracture injuries between January 2017 and June 2018. Of those, 59 percent were treated surgically and 41 percent were treated non-surgically. The team stratified the results by dementia severity and hip fracture location and analyzed mortality rates within 30, 90, and 180 days post-surgery. They found that in cases where the hip fracture occurred in the head and neck of the femur bone, which was the most common type of hip fracture, patients with both moderate-to-severe dementia and mild dementia who were treated surgically experienced lower odds of death than patients treated non-surgically. Patients with fractures in other locations of the hip however did not experience this benefit with surgery.
Other findings included that patients with moderate-to-severe dementia who were treated surgically were more likely to experience delirium during their inpatient hospital stay compared to patients treated non-surgically, and that there was no difference in nursing home admission between patients treated surgically and patients treated non-surgically.
Adler’s team plans to extend this work to study longitudinal patient-reported outcomes of people living with dementia, including before and after different types of surgery and treatments for other health conditions, to better understand the impacts of their healthcare decisions.
“When making decisions about surgery, it is really important to think about the patient’s quality-of-life goals,” Adler said. “This analysis provides valuable information for clinicians caring for people living with dementia in their communities, and can help them talk with this group of patients and their caregivers about what is most important to them.”
Authorship: Additional authors include Lingwei Xiang, Samir K. Shah, Clancy J. Clark, Zara Cooper, Susan L. Mitchell, Dae Hyun Kim, John Hsu, Karen Sepucha, Richard E. Chunga, Stuart R. Lipsitz, Joel S. Weissman, and Andrew J. Schoenfeld.
Disclosures: None.
Funding: This work was supported by the National Institute on Aging (R01AG067507, P01AG032952, R01AG062282, RF1AG083033, and U01AG076478) and the Alzheimer’s Association (AARF-22-974113).
Paper cited: Rachel Adler, et al. “Hip fracture treatment and outcomes among community-dwelling people living with dementia.” JAMA Network Open, DOI: 10.1001/jamanetworkopen.2024.13878
END
New study finds people living with dementia who had surgery for hip fractures lived longer than those treated non-surgically
Brigham researchers’ findings can help those living with dementia and their caregivers determine the best treatment approach after a hip fracture injury
2024-05-30
ELSE PRESS RELEASES FROM THIS DATE:
Climate change: Reduced sulphur content in shipping fuel associated with increased maritime atmospheric warming
2024-05-30
An 80% reduction in sulphur dioxide shipping emissions observed in early 2020 could be associated with substantial atmospheric warming over some ocean regions, according to a modelling study published in Communications Earth & Environment. The sudden decline in emissions was a result of the introduction of the International Maritime Organization’s 2020 regulation (IMO 2020), which reduced the maximum sulphur content allowed in shipping fuel from 3.5% to 0.5% to help reduce air pollution.
Fuel oil used for large ships has a significantly higher percentage content ...
Research spotlight: Illuminating the mechanisms behind severe inflammation in asthma
2024-05-30
How would you summarize your study for a lay audience?
Previous research indicates that mast cells, a type of immune cell found in the tissues throughout the body, cause inflammation during an asthma attack, inducing symptoms such as trouble breathing and narrowing of the airways. Our study demonstrates that prostaglandin E2 (PGE2), a naturally occurring chemical in the human body previously thought to inhibit mast cell activation, elicits mast cells to prevent inflammation by creating a molecule called soluble ST2 (sST2), which can mitigate signs and symptoms of asthma by blocking the actions of interleukin 33, a powerful proinflammatory ...
Understanding how zwitterionic polymers can lead to safer drugs and disease prevention
2024-05-30
Ishikawa, Japan -- Proteins are vital biomolecules responsible for performing various functions in the human body and are thus regarded as the workhorses of a cell. The primary structure of a protein is composed of different amino acids coming together. The structure so formed then undergoes protein folding, a process by which a protein acquires its characteristic and functional three-dimensional configuration. This state, referred to as the ‘native state’, is crucial for proper protein function. Unfavorable conditions, ...
Florida Inventors Hall of Fame celebrates 2024 inductees: Ushering in a new era of innovation
2024-05-30
TAMPA, Fla (May 30, 2024) – The Florida Inventors Hall of Fame has announced its 2024 inductees: nine visionaries whose groundbreaking inventions have propelled technological advancement and reshaped the landscape of American innovation. These inventors exemplify Florida’s rich tradition of ingenuity.
Paul R. Sanberg, chair of the Florida Inventors Hall of Fame Advisory Board and president of the National Academy of Inventors, said of the new inductees: "The Class of 2024 represents the best of innovation in Florida, and their achievements underscore the critical role that innovation plays in driving progress and improving the quality of ...
Inducing piezoelectricity in distorted rutile TiO2 for enhanced tetracycline hydrochloride degradation through photopiezocatalysis
2024-05-30
A team of material scientists led by Prof. Qi Li from Southwest Jiaotong University in Chengdu, China recently outlined the state of inducing piezoelectricity in distorted rutile TiO2 for enhanced tetracycline hydrochloride degradation through photopiezocatalysis. Various material design strategies have been developed to enhance photocatalytic performance of TiO2. However, no report is available on applications of the photopiezocatalysis strategy on TiO2 due to its lack of piezoelectricity. Here we developed a low-temperature molten salt etching process to create rutile TiO2 nanoparticles by etching [MgO6] ...
Physical and chemical properties of boiled oil: A traditional method of extracting oil from boiled olive fruits
2024-05-30
In certain towns in Northern Jordan, ranchers bubble some portion of their olive natural product gathered before oil extraction to expand the amount of oil, . They perceive it as a way to get a beneficial mixed bag, as they guarantee, and to get extra medical advantages. Local peoples call this oil Bubbled oil (BO), and its cost is around 20% higher than virgin olive oil (VOO) created by a similar rancher.
The speculation was thatpractice revolves around the belief that bubbling olive natural products might influence the nature of the created oil. Hence, ourResearchers from the Department of Nutrition and Food Technology, ...
Existing drug shows promise as treatment for rare genetic disorder
2024-05-30
WHAT:
A drug approved to treat certain autoimmune diseases and cancers successfully alleviated symptoms of a rare genetic syndrome called autoimmune polyendocrine syndrome type 1 (APS-1). Researchers identified the treatment based on their discovery that the syndrome is linked to elevated levels of interferon-gamma (IFN-gamma), a protein involved in immune system responses, providing new insights into the role of IFN-gamma in autoimmunity. The study, led by researchers at the National Institutes of Health’s National Institute ...
Study examines prescribing patterns of drug associated with cognitive impairment
2024-05-30
INDIANAPOLIS -- Many adults with diabetes and the associated complication of peripheral neuropathy, which can be painful as well as harmful, are often prescribed drugs at doses and for durations that could impose an increased risk of cognitive impairment.
A new study, led by Regenstrief Institute and Purdue University College of Pharmacy Research Scientist Noll Campbell, PharmD, M.S., is one of the first explorations of prescribing patterns of tricyclic antidepressants for treatment of diabetic peripheral neuropathy at healthcare facilities predominantly serving diverse populations of low socioeconomic status.
With a study population of adults 18 years and older that ...
Cheap, dirty leftovers can produce pure oxygen
2024-05-30
New materials for producing oxygen may challenge traditional production methods. This is exciting news, because pure oxygen is in demand from many areas in industry and medicine.
“We have identified materials that can store and release pure oxygen much faster and at much lower temperatures than known materials currently used for this purpose,” says Professor Sverre Magnus Selbach at the Norwegian University of Science and Technology (NTNU’s) Department of Materials Science and Engineering.
Oxygen is an element, so it ...
Violence, aggression against educators grew post-pandemic
2024-05-30
While threats and violence against pre-K to 12th-grade teachers and other school personnel in the United States declined during the pandemic, after the restrictions were lifted, incidents rebounded to levels equal to or exceeding those prior to the pandemic, according to research published by the American Psychological Association.
As a result, the percentage of teachers expressing intentions to resign or transfer rose from 49% during the pandemic to 57% afterward, the researchers found.
“Aggression and violence against educators and school personnel are major concerns that affect the well-being of school personnel and the ...
LAST 30 PRESS RELEASES:
New study sheds light on Milky Way's mysterious chemical history
Could altering the daily timing of immunotherapy improve survival in people with cancer?
Weaving secondary battery electrodes with fibers and tying them like ropes for both durability and performance
Using social media may impair children’s attention
Science briefing: An update on GLP-1 drugs for obesity
Lower doses of immunotherapy for skin cancer give better results
Why didn’t the senior citizen cross the road? Slower crossings may help people with reduced mobility
ASH 2025: Study suggests that a virtual program focusing on diet and exercise can help reduce side effects of lymphoma treatment
A sound defense: Noisy pupae puff away potential predators
Azacitidine–venetoclax combination outperforms standard care in acute myeloid leukemia patients eligible for intensive chemotherapy
Adding epcoritamab to standard second-line therapy improves follicular lymphoma outcomes
New findings support a chemo-free approach for treating Ph+ ALL
Non-covalent btki pirtobrutinib shows promise as frontline therapy for CLL/SLL
University of Cincinnati experts present research at annual hematology event
ASH 2025: Antibody therapy eradicates traces of multiple myeloma in preliminary trial
ASH 2025: AI uncovers how DNA architecture failures trigger blood cancer
ASH 2025: New study shows that patients can safely receive stem cell transplants from mismatched, unrelated donors
Protective regimen allows successful stem cell transplant even without close genetic match between donor and recipient
Continuous and fixed-duration treatments result in similar outcomes for CLL
Measurable residual disease shows strong potential as an early indicator of survival in patients with acute myeloid leukemia
Chemotherapy and radiation are comparable as pre-transplant conditioning for patients with b-acute lymphoblastic leukemia who have no measurable residual disease
Roughly one-third of families with children being treated for leukemia struggle to pay living expenses
Quality improvement project results in increased screening and treatment for iron deficiency in pregnancy
IV iron improves survival, increases hemoglobin in hospitalized patients with iron-deficiency anemia and an acute infection
Black patients with acute myeloid leukemia are younger at diagnosis and experience poorer survival outcomes than White patients
Emergency departments fall short on delivering timely treatment for sickle cell pain
Study shows no clear evidence of harm from hydroxyurea use during pregnancy
Long-term outlook is positive for most after hematopoietic cell transplant for sickle cell disease
Study offers real-world data on commercial implementation of gene therapies for sickle cell disease and beta thalassemia
Early results suggest exa-cel gene therapy works well in children
[Press-News.org] New study finds people living with dementia who had surgery for hip fractures lived longer than those treated non-surgicallyBrigham researchers’ findings can help those living with dementia and their caregivers determine the best treatment approach after a hip fracture injury



