PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Recent study reveals key immune cells as critical factors in lung cancer prognosis

T cell study offers new hope for personalized lung cancer treatment

Recent study reveals key immune cells as critical factors in lung cancer prognosis
2024-07-30
(Press-News.org) (LOS ANGELES, July 30, 2024) – An extensive analytical study performed at the Terasaki Institute and published in Frontiers in Immunology highlights the crucial role of tissue-resident memory T cells and how they influence the immune environment of patients with non-small cell lung cancer and their overall prognosis.

Non-small cell lung cancer accounts for ~85% of lung tumors and is a leading cause of death in adults. Tissue-resident memory T cells, a specialized subset of immune cells residing in peripheral tissues, have been suspected of impacting cancer progression. However, it’s still not fully understood how tissue-resident memory T cells affect the tumor immune microenvironment and tumor progression in various non-small cell lung cancer patient populations.

In this comprehensive study, multiple independent datasets from lung cancer patient samples were analyzed. In addition, a machine learning model was developed and validated to predict patient survival, refining an 18-gene risk score that effectively categorizes lung cancer patients into low-risk and high-risk groups. In cancer research, the 18-gene risk score is used to predict disease progression or recurrence chances, which helps create personalized treatment plans. The scores are usually divided into low and high risk, with specific thresholds setting these categories. In this study, patients with high-risk scores exhibited significantly lower overall survival rates than their low-risk counterparts. Distinct Tissue Resident Memory T cell biomarkers were identified that correlate positively with other immune cells within the tumor environment. Moreover, these biomarkers were strongly associated with immune checkpoint and stimulatory genes, directly influencing patient prognosis.

"The study's findings highlight the critical impact of Tissue Resident Memory T cell abundance on immune responses and patient outcomes in lung cancer," said Dr. Xiling Shen, Chief Scientific Officer at Terasaki Institute for Biomedical Innovation. "Our findings not only validate these cells as a prognostic marker but also underscore their potential in guiding personalized treatment strategies, particularly in immunotherapy."

This pioneering research, independently validated by the Cancer Genome Atlas Program and multiple lung cancer patient datasets, provides a deeper understanding of the complex interplay between Tissue Resident Memory T cells and the tumor. It represents a significant step towards advancing precision medicine in lung cancer treatment.

 

 

 

 

Authors: Aidan Shen, Aliesha Garrett, Cheng-Chi Chao , Dongliang Liu, Chao Cheng, Zhaohui Wang, Chen Qian, Yangzhi Zhu, Junhua Mai, Chongming Jiang

 

Grant Information: The author(s) declare financial support was received for the

research, authorship, and/or publication of this article. This work is

supported by the National Institutes of Health, United States (NIH)

 

For more information, please visit Terasaki.org or Contact:

 

Stewart Han

Email: shan@terasaki.org

 

Chongming Jiang

Email: tom.jiang@terasaki.org

 

###

 

About Terasaki Institute for Biomedical Innovation

 

The Terasaki Institute for Biomedical Innovation is a non-profit research organization dedicated to leveraging cutting-edge technology to address global health challenges. By fostering interdisciplinary collaborations and pushing the boundaries of innovation, TIBI aims to transform healthcare and improve lives worldwide.

END

[Attachments] See images for this press release:
Recent study reveals key immune cells as critical factors in lung cancer prognosis Recent study reveals key immune cells as critical factors in lung cancer prognosis 2 Recent study reveals key immune cells as critical factors in lung cancer prognosis 3

ELSE PRESS RELEASES FROM THIS DATE:

Accuracy of diagnostic blood tests for Alzheimer’s disease varies

2024-07-30
Neurologists diagnose cognitive impairment with a clinical exam of memory and thinking skills. To determine whether Alzheimer’s disease is the cause of the cognitive impairment, evidence of the specific brain changes that characterize Alzheimer’s must be obtained, typically via a brain scan or spinal tap. Identifying people whose cognitive symptoms are due to Alzheimer’s disease is critical now that new Alzheimer’s therapies are available that could change the course of the illness. To make diagnosis more convenient for patients, many companies have begun selling Alzheimer’s ...

Ze’ev Ronai steps down as cancer center director at Sanford Burnham Prebys

Ze’ev Ronai steps down as cancer center director at Sanford Burnham Prebys
2024-07-30
Ze’ev Ronai, PhD, is stepping down as director of the National Cancer Institute-designated cancer center at Sanford Burnham Prebys, effective August 1. Cosimo Commisso, PhD, deputy director of the cancer center, will serve as interim head while a national search is conducted for a new cancer center director.   Ronai is moving to Cedars-Sinai Medical Center in Los Angeles where he will focus on translational research.   “During my 20 years at Sanford Burnham Prebys, I’ve had the honor of developing new research directions, institutionally, as well as in my lab,” said Ronai.   “As the director of the cancer ...

FSU researchers identify unique phenomenon in Kagome metal

FSU researchers identify unique phenomenon in Kagome metal
2024-07-30
In traditional Japanese basket-weaving, the ancient “Kagome” design seen in many handcrafted creations is characterized by a symmetrical pattern of interlaced triangles with shared corners. In quantum physics, the Kagome name has been borrowed by scientists to describe a class of materials with an atomic structure closely resembling this distinctive lattice pattern. Since the latest family of Kagome metals was discovered in 2019, physicists have been working to better understand their properties and potential applications. A new study led by Florida State University Assistant Professor of ...

Ochsner-Xavier Institute for Health Equity and Research publishes strategic plan

2024-07-30
NEW ORLEANS – The Ochsner-Xavier Institute for Health Equity and Research, or OXIHER, has published its first strategic plan, outlining strategic priorities and achievements since the institute began in 2020.   The strategic plan is available here.  A partnership between Ochsner Health and Xavier University of Louisiana, OXIHER examines health disparities at the community level while educating healthcare providers on creating and nurturing a culture of equity, and training more students for advanced careers in healthcare. The new plan details OXIHER’s substantial progress in its first three years in addressing ...

Argonne receives U.S. Department of Energy funding for four next-generation clean-energy projects

Argonne receives U.S. Department of Energy funding for four next-generation clean-energy projects
2024-07-30
The U.S. Department of Energy’s (DOE) Argonne National Laboratory has been awarded funding from DOE’s Office of Technology Transitions for four new projects that will help with commercialization of innovative clean-energy technology for a sustainable future. Argonne scientists will work to turn their innovative ideas into next-generation technology necessary to build cleaner, more resilient energy systems. These projects build on Argonne’s decades-long role at the forefront of the quest to decarbonize ...

Researchers develop general framework for designing quantum sensors

2024-07-30
Researchers from North Carolina State University and the Massachusetts Institute of Technology have designed a protocol for harnessing the power of quantum sensors. The protocol could give sensor designers the ability to fine-tune quantum systems to sense signals of interest, creating sensors that are vastly more sensitive than traditional sensors. “Quantum sensing shows promise for more powerful sensing capability that can approach the fundamental limit set by the law of quantum mechanics, but the challenge lies in being able to direct ...

UBC super-black wood can improve telescopes, optical devices and consumer goods

UBC super-black wood can improve telescopes, optical devices and consumer goods
2024-07-30
Thanks to an accidental discovery, researchers at the University of British Columbia have created a new super-black material that absorbs almost all light, opening potential applications in fine jewelry, solar cells and precision optical devices.  Professor Philip Evans and PhD student Kenny Cheng were experimenting with high-energy plasma to make wood more water-repellent. However, when they applied the technique to the cut ends of wood cells, the surfaces turned extremely black.  Measurements by Texas A&M University’s ...

Repair kit for NASA’s NICER mission heading to space station

Repair kit for NASA’s NICER mission heading to space station
2024-07-30
NASA will deliver a patch kit for NICER (Neutron star Interior Composition Explorer), an X-ray telescope on the International Space Station, on the agency’s Northrop Grumman 21st commercial resupply mission. Astronauts will conduct a spacewalk to complete the repair. Located near the space station’s starboard solar array, NICER was damaged in May 2023. The mission team delivered the patch kit to NASA’s Johnson Space Center in Houston in May 2024 so it could be prepped and packed for the upcoming resupply mission. “It’s ...

Mucus-based bioink could be used to print and grow lung tissue

Mucus-based bioink could be used to print and grow lung tissue
2024-07-30
Lung diseases kill millions of people around the world each year. Treatment options are limited, and animal models for studying these illnesses and experimental medications are inadequate. Now, researchers describe in ACS Applied Bio Materials their success in creating a mucus-based bioink for 3D printing lung tissue. This advance could one day help study and treat chronic lung conditions. While some people with lung diseases receive transplants, donor organs remain in short supply. As an alternative, medications and other treatments can be used to manage symptoms, but no cure is available for disorders such as chronic obstructive ...

Who is more polarized about AI—the tech community or the general public?

2024-07-30
The tech community is more strongly divided in how they feel about artificial intelligence (AI) than the general public according to a study of Reddit discourse following the launch of ChatGPT. Researchers from the University of Rochester led by Jiebo Luo, a professor of computer science and the Albert Arendt Hopeman Professor of Engineering, used ChatGPT and natural language processing techniques to analyze the themes and sentiments of 33,912 comments in 388 unique subreddits in the roughly six months following the generative AI tool’s launch in November 2022. The findings appear in Telematics and Informatics. Reddit is an online social ...

LAST 30 PRESS RELEASES:

CMD-OPT model enables the discovery of a potent and selective RIPK2 inhibitor as preclinical candidate for the treatment of acute liver injury

Melatonin receptor 1a alleviates sleep fragmentation-aggravated testicular injury in T2DM by suppression of TAB1/TAK1 complex through FGFR1

Single-cell RNA sequencing reveals Shen-Bai-Jie-Du decoction retards colorectal tumorigenesis by regulating the TMEM131–TNF signaling pathway-mediated differentiation of immunosuppressive dendritic ce

Acta Pharmaceutica Sinica B Volume 15, Issue 7 Publishes

New research expands laser technology

Targeted radiation offers promise in patients with metastasized small cell lung cancer to the brain

A high clinically translatable strategy to anti-aging using hyaluronic acid and silk fibroin co-crosslinked hydrogels as dermal regenerative fillers

Mount Sinai researchers uncover differences in how males and females change their mind when reflecting on past mistakes

CTE and normal aging are difficult to distinguish, new study finds

Molecular arms race: How the genome defends itself against internal enemies

Tiny chip speeds up antibody mapping for faster vaccine design

KTU experts reveal why cultural heritage is important for community unity

More misfolded proteins than previously known may contribute to Alzheimer’s and dementia

“Too much going on”: Autistic adults overwhelmed by non-verbal social cues

What’s driving America’s deep freezes in a warming world?

A key role of brain protein in learning and memory is deciphered by scientists

Heart attacks don’t follow a Hollywood script

Erin M. Schuman wins 2026 Nakasone Award for discovery on neural synapse function and change during formation of memories

Global ocean analysis could replace costly in-situ sound speed profiles in seafloor positioning, study finds

Power in numbers: Small group professional coaching reduces rates of physician burnout by nearly 30%

Carbon capture, utilization, and storage: A comprehensive review of CCUS-EOR

New high-temperature stable dispersed particle gel for enhanced profile control in CCUS applications

State gun laws and firearm-related homicides and suicides

Use of tobacco and cannabis following state-level cannabis legalization

Long-term obesity and biological aging in young adults

Eindhoven University of Technology and JMIR Publications announce unlimited open access publishing agreement

Orphan nuclear receptors in metabolic dysfunction-associated steatotic liver disease development

A technological breakthrough for ultra-fast and greener AI

Pusan National University researchers identify key barriers hindering data-driven smart manufacturing adoption

Inking heterometallic nanosheets: A scalable breakthrough for coating, electronics, and electrocatalyst applications

[Press-News.org] Recent study reveals key immune cells as critical factors in lung cancer prognosis
T cell study offers new hope for personalized lung cancer treatment