Comparative safety of in utero exposure to buprenorphine combined with naloxone vs buprenorphine alone

JAMA

2024-08-12

(Press-News.org) About The Study: There were similar and, in some instances, more favorable neonatal and maternal outcomes for pregnancies exposed to buprenorphine combined with naloxone compared with buprenorphine alone. For the outcomes assessed, compared with buprenorphine alone, buprenorphine with naloxone during pregnancy appears to be a safe treatment option. This supports the view that both formulations are reasonable options for the treatment of opioid use disorder in pregnancy, affirming flexibility in collaborative treatment decision-making.

Corresponding Author: To contact the corresponding author, Loreen Straub, MD, MS, email lstraub@bwh.harvard.edu.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jama.2024.11501)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

# # #

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2024.11501?guestAccessKey=13abe6ab-07a2-438b-aa67-5315bc3e3938&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=081224

END

ELSE PRESS RELEASES FROM THIS DATE:

Pink elephants in the brain?

2024-08-12

Our brain interprets visual information by combining what we see with what we already know. A study published in the journal Neuron by researchers at the Champalimaud Foundation, and supported by the CaixaResearch Health Call of the la Caixa Foundation, reveals a mechanism for learning and storing this existing knowledge about the world. They found that neurons are wired to connect seemingly unrelated concepts. This wiring may be crucial for enhancing the brain’s ability to predict what we see based on past experiences, and bring us a step closer to understanding how this process goes awry ...

Heat caused over 47,000 deaths in Europe in 2023, the second highest burden of the last decade

2024-08-12

More than 47,000 people died in Europe as a result of high temperatures in 2023, the warmest year on record globally and the second warmest in Europe. This is the estimate of a study led by the Barcelona Institute for Global Health (ISGlobal), a centre supported by the "la Caixa" Foundation, and published in Nature Medicine. The researchers report that the vulnerability to heat of European societies has progressively decreased over the present century, and estimate that without these societal adaptation processes, the heat related mortality burden over the past year would have been 80% higher. The study replicates the methodology used last year in another paper ...

Early-childhood tablet use and outbursts of anger

2024-08-12

About The Study: Child tablet use at age 3.5 years was associated with more expressions of anger and frustration by the age of 4.5 years in this study. Child proneness to anger/frustration at age 4.5 years was then associated with more use of tablets by age 5.5 years. These results suggest that early-childhood tablet use may contribute to a cycle that is deleterious for emotional regulation. Corresponding Author: To contact the corresponding author, Caroline Fitzpatrick, PhD, email caroline.fitzpatrick@usherbrooke.ca. To access the embargoed ...

Alcohol consumption patterns and mortality among older adults with health-related or socioeconomic risk factors

2024-08-12

About The Study: In this cohort study of older drinkers from the UK, even low-risk drinking was associated with higher mortality among older adults with health-related or socioeconomic risk factors. The attenuation of mortality observed for wine preference and drinking only during meals requires further investigation, as it may mostly reflect the effect of healthier lifestyles, slower alcohol absorption, or nonalcoholic components of beverages. Corresponding Author: To contact the corresponding author, Rosario Ortolá, MD, PhD, ...

An appetizer can stimulate immune cells’ appetite, a boon for cancer treatments

2024-08-12

(Santa Barbara, Calif.) — The body has a veritable army constantly on guard to keep us safe from microscopic threats from infections to cancer. Chief among this force is the macrophage, a white blood cell that surveils tissues and consumes pathogens, debris, dead cells, and cancer. Macrophages have a delicate task. It’s crucial that they ignore healthy cells while on patrol, otherwise they could trigger an autoimmune response while performing their duties. Researchers at UC Santa Barbara sought to understand how these immune cells choose what and when to eat. A paper published ...

New genetically engineered wood can store carbon and reduce emissions

2024-08-12

Researchers at the University of Maryland genetically modified poplar trees to produce high-performance, structural wood without the use of chemicals or energy intensive processing. Made from traditional wood, Engineered wood is often seen as a renewable replacement for traditional building materials like steel, cement, glass and plastic. It also has the potential to store carbon for a longer time than traditional wood because it can resist deterioration, making it useful in efforts to reduce carbon emissions. But the hurdle to true sustainability in engineered wood is that it requires processing with volatile chemicals and a significant amount of energy, and ...

NK cells expressing interleukin-21 show promising antitumor activity in glioblastoma cells

2024-08-12

Natural killer (NK) cells engineered to express interleukin-21 (IL-21) demonstrated sustained antitumor activity against glioblastoma stem cell-like cells (GSCs) both in vitro and in vivo, according to new research from The University of Texas MD Anderson Cancer Center. The preclinical findings, published today in Cancer Cell, represent the first evidence that engineering NK cells, a type of innate immune cell, to secrete IL-21 resulted in strong activity against glioblastoma, a cancer type in need of more effective treatment options. “Our ...

Strong insurance laws help kids get access to mental health care

2024-08-12

When states require insurers to cover mental and behavioral health, children get better access to care, according to a UC San Francisco-led study of nearly 30,000 U.S. caregivers. They found that 1 in 8 caregivers had difficulty accessing mental health services for their children between 2016 and 2019. But those who lived in states with the most comprehensive mental and behavioral health coverage laws were about 20% less likely to report trouble accessing care than those who lived in states with the least comprehensive laws. Caregivers of Black and Asian children were more likely to report poor access to mental and ...

State-of-the-art brain recordings reveal how neurons resonate

2024-08-12

For decades, scientists have focused on how the brain processes information in a hierarchical manner, with different brain areas specialized for different tasks. However, how these areas communicate and integrate information to form a coherent whole has remained a mystery. Now, researchers at University of California San Diego School of Medicine have brought us closer to solving it by observing how neurons synchronize across the human brain while reading. The findings are published in Nature Human Behavior and are also the basis of a thesis by UC San Diego School of Medicine doctoral candidate Jacob Garrett. “How the activity of the brain relates to the subjective ...

New study reveals unique histone tag in adult oligodendrocyte progenitor cells, opening doors for advanced myelin repair therapies

2024-08-12

NEW YORK, August 12, 2024 — In a groundbreaking study, researchers with the Advanced Science Research Center at the CUNY Graduate Center (CUNY ASRC) have identified a distinct histone tag in adult oligodendrocyte progenitor cells (OPCs) that may pave the way for innovative therapies targeting myelin repair, a critical target for several neurodegenerative and psychiatric disorders, including multiple sclerosis, Alzheimer’s disease, and schizophrenia. The histone tag, characterized by lysine 8 acetylation on histone H4, identifies a significant departure from the histone modifications found in neonatal OPCs. Detailed in a ...

Comparative safety of in utero exposure to buprenorphine combined with naloxone vs buprenorphine alone

ELSE PRESS RELEASES FROM THIS DATE:

LAST 30 PRESS RELEASES: