Characterizing long COVID in children and adolescents

JAMA

2024-08-21

(Press-News.org) About The Study: In this large-scale study, symptoms that characterized pediatric postacute sequelae of SARS-CoV-2 infection (PASC), or long COVID, differed by age group, and several distinct phenotypic PASC presentations were described. The research indices developed here will help researchers identify children and adolescents with high likelihood of PASC. Although these indices will require further research and validation, this work provides an important step toward a clinically useful tool for diagnosis with the ultimate goal of supporting optimal care for youth with PASC.

Quote from corresponding author Rachel S. Gross, MD, MS:

“Our study is one of the first of its kind to characterize long COVID symptoms in children across age groups and develop a tool to help identify those who are most likely to have long COVID. This is important because there remains a common misperception that pediatric long COVID is rare, and this research can raise awareness of its impact on children.

“For this study, we looked at different groupings of symptoms across varying childhood ages and found that many of the symptoms were similar, but distinguishable from each other. Understanding why these differences occur can help inform future treatment tailored for specific age groups.”

Contact information for Rachel S. Gross, MD, MS: email Domonique Chaplin at Domonique.Chaplin@nyulangone.org.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jama.2024.12747)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

# # #

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2024.12747?guestAccessKey=bbe06786-8f16-435f-a2b4-bb71986c6ccc&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=082124

END

ELSE PRESS RELEASES FROM THIS DATE:

Researchers aim to pull back the curtain on long COVID in kids

2024-08-21

The kids were correct all along. In the most comprehensive national study since the onset of the COVID-19 pandemic, a team of researchers that includes a Rutgers-organized consortium of pediatric sites has concluded that long COVID symptoms in children are tangible, pervasive, wide ranging and clinically distinct within specific age groups. Results of the study, funded by the National Institutes of Health (NIH), are published in the Journal of the American Medical Association. “We have convincing evidence that COVID-19 is not just a mild, benign illness for children,” ...

RECOVER study determines most common long COVID symptoms in children and teens

2024-08-21

A research team led by the National Institutes of Health’s RECOVER Initiative and supported by its Clinical Science Core (CSC) at NYU Langone Health, has designed a new way to identify which school-age children and adolescents most likely have Long COVID. Solely for the purpose of further study and not for use in clinical diagnoses, the team’s new measure (index) identifies children and teens with the highest chances of having Long COVID. The research index is based on long-term symptoms ...

UCLA-led study unveils new insights and potential treatments for pulmonary hypertension

2024-08-21

A new study from researchers with UCLA Health and collaborating organizations has found that asporin, a protein encoded by the ASPN gene, plays a protective role in pulmonary arterial hypertension (PAH). Their findings, published on August 21 in the peer-reviewed journal Circulation, offer new insights into this incurable, often-fatal disease and suggest potential new ways to treat it. “We were surprised to find that asporin, which previously had not been linked to PAH, gets upregulated to increased levels as a response to ...

MD Anderson research highlights for August 21, 2024

2024-08-21

HOUSTON ― The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back. Targeting an enzyme as part of combination therapy disrupts gastric cancer progression Many patients with gastric cancer have metastatic disease at the time of diagnosis, ...

Proatherogenic disorders of blood lipid and lipoprotein metabolism in patients with rheumatoid arthritis

2024-08-21

In the realm of chronic inflammation, lipid abnormalities are well-recognized as pivotal contributors to the progression and clinical manifestations of atherosclerosis. Particularly in rheumatoid arthritis (RA), a systemic autoimmune disorder, the immune response leads to the generation of inflammatory cytokines that profoundly alter lipid and lipoprotein metabolism. This review article delves into the latest research exploring the impact of inflammation on proatherogenic disorders of lipid and lipoprotein metabolism in RA patients, with a focus on proinflammatory cytokines. Role of Proinflammatory Cytokines in Lipid and Lipoprotein Dysregulation Inflammatory ...

Pioneering study shows effective regulation and monitoring is key to tackling emissions of a super-greenhouse gas

2024-08-21

New research has revealed factories globally are not properly destroying one of the most potent greenhouse gases emitted from the production of fluoropolymers like Teflon, and refrigerants. The study investigated a known disparity between real and reported emissions of this gas, prompting calls for more countries to sign up to official agreements to limit emissions and for their Teflon factories to be independently audited to ensure compliance. The study, published today in the journal Nature, scrutinised emissions of one of the most potent hydrofluorocarbon (HFC) greenhouse gases called trifluoromethane, also ...

Inflammation during childhood linked to onset of mental health issues in early adulthood – study reveals

2024-08-21

Children who have persistently raised inflammation are at a higher risk of experiencing serious mental health disorders including psychosis and depression in early adulthood, according to a study published today in JAMA Psychiatry. The research lead by the University of Birmingham also found that those who had experienced inflammation at a young age were at a higher risk of developing cardiometabolic diseases such as insulin resistance - an early form of diabetes. The study used data collected by the Avon Longitudinal Study of Parents and Children (ALSPAC) – also known as Children of the 90s – and included a total of 6,556 participants of whom 50.4% ...

Study finds sex-based disparities in outcomes after cardiac surgery

2024-08-21

Mass General Brigham researchers found that women had a lower risk of developing postoperative atrial fibrillation after surgery compared to men, but a higher risk of long-term mortality New research suggests that women who develop postoperative atrial fibrillation (poAF) after cardiac surgery are at greater risk of death than men. A study led by Mass General Brigham researchers found that women may have protective factors against the development of poAF, but once it develops, they may be more vulnerable to its associated long-term morbidities. The researchers suggest that more vigilant monitoring and long-term ...

Study of 18 million people finds increased mental illnesses incidence following severe COVID-19, especially in unvaccinated people

2024-08-21

A new study that examined health data on 18 million people reveals higher incidence of mental illnesses for up to a year following severe COVID-19 in unvaccinated people. Vaccination appeared to mitigate the adverse effects of COVID-19 on mental illnesses. The University of Bristol-led study, published in JAMA Psychiatry today [21 August], investigated associations of COVID-19 with mental illnesses according to time since diagnosis and vaccination status. COVID-19 is associated with mental illnesses in both hospital and population-based studies. However, until now, there was limited evidence about the association of COVID-19 with ...

Nearly 90 percent of NYC transit workers have been harassed or assaulted

2024-08-21

The COVID-19 pandemic brought an increase in crime to New York City’s subways and buses. The transit system’s employees—especially female workers—have frequently been on the receiving end of attacks, according to a new study published in the Journal of Urban Health. The study, led by researchers at the NYU School of Global Public Health, found that 89 percent of public-facing transit workers in New York City experienced harassment or violence on the job during the pandemic (2020-2023). “Transit workers are our city’s unsung heroes—they kept New York City functioning during the COVID-19 pandemic, ...

Characterizing long COVID in children and adolescents

ELSE PRESS RELEASES FROM THIS DATE:

LAST 30 PRESS RELEASES: