Atomic resolution of the broad-spectrum antiviral drug cascade to facilitate the design of antiviral drugs

One in every three FDA-approved drugs targets a single superfamily of receptors dotting the surfaces of human cells. From beta blockers to antihistamines, these essential, life-saving medications trigger winding biochemical pathways, via these receptors, to ultimately prevent a heart attack, or stop an allergic reaction in its tracks. But scientists have learned that their story is much more complicated than initially believed—a number of these drugs are in fact targeting a complex composed of one receptor and one associated protein. Now, a ...

COLUMBUS, Ohio – Not all communities in the United States face the same risks for environmental problems such as air pollution, noise and wastewater.  But how can federal agencies fairly identify which areas deserve the most help?   A new consensus study report from the National Academies of Sciences, Engineering and Medicine (NASEM) offer recommendations for developing tools that can help answer that question.   “Our job was to create methods to identify disadvantaged communities that most need federal resources to address environmental justice issues,” said Harvey Miller, ...

Wiener Studying Learning & Metacognition For The Perception Of Time Martin Wiener, Associate Professor, Psychology, College of Humanities and Social Sciences (CHSS), received funding to study learning and metacognition for the perception of time.  Via this research, Wiener will conduct a series of studies that will inform metacognition and interval timing. He holds that this work will lead to a new domain of study to further understand how humans learn and adapt to temporal intervals. By understanding how the brain measures and learns intervals of time, we can better understand ...

Dumas Receives Funding For Study Of How Distinct NMDA Receptor Signaling Domains Regulate Hippocampal Network Dynamics Theodore Dumas, Associate Professor, Psychology, College of Humanities and Social Sciences (CHSS), received funding for the project: “Distinct NMDA receptor signaling domains regulate hippocampal network dynamics. Dumas and his collaborators hypothesize that in wildtype mice, NMDA receptors regulate hippocampal network oscillatory activity (slow gamma frequency) in the absence of ion conductance (nonionotropic) and that enhancing GluN2B subunit-type nonionotropic signaling will increase slow gamma power and enhance spatial memory retrieval. The researchers ...

DNA methylation is a process in which a methyl group is attached to the cytosine base of the DNA molecule, and a major way that DNA is epigenetically marked. Epigenetic modifications can act as on-off switches to regulate gene expression and help generate diverse cell types without changing the underlying DNA sequence. It is how the body ensures that brain-related genes don’t get turned on in heart cells, for example. For this reason, maintenance of the DNA methylation pattern is important to ensure the correct and consistent function of each cell type. But this is no easy feat: the DNA methylation pattern can change over time, and this is linked to a variety of diseases. One ...

In recent years, advances in photonics and materials science have led to remarkable developments in sensor technology, pushing the boundaries of what can be detected and measured. Among these innovations, non-Hermitian physics has emerged as a crucial area of research, offering new ways to manipulate light and enhance sensor sensitivity. A recent study published in Advanced Photonics Nexus reports a breakthrough in this field, presenting a new type of sensor that leverages exceptional points (EPs) to achieve unprecedented levels of sensitivity. This study introduces a highly sensitive and reconfigurable sensor based on a single ...

LOS ANGELES — Over 6.5 million Americans experience chronic wounds — wounds that do not heal after a few months. Almost all such wounds contain bacteria, which, if not detected and removed, can lead to severe infection and resulting complications, including amputation if a limb is involved.  This is especially true for patients with diabetic foot ulcers (open sores), which affects one-third of people with diabetes. Approximately 20% of those who develop a diabetic foot ulcer will require a lower-extremity amputation, according ...

UCLA has received a $120 million commitment from surgeon, inventor and philanthropist Dr. Gary Michelson and his wife, Alya, to kick-start the California Institute for Immunology and Immunotherapy, an innovative public-private partnership aimed at spurring breakthrough discoveries that prevent and cure diseases and catalyze economic growth and innovation in Los Angeles.  Michelson, a spine surgeon and prolific inventor who holds nearly 1,000 individual patents, is co-founder and chair of the board of the institute, which will be housed at UCLA’s state-of-the-art research park. The gift, distributed via ...

Dunick Receives Funding For Center For Economic Education Jason Dunick, Associate Chair and Term Associate Professor, Economics, College of Humanities and Social Sciences (CHSS), received $108,692 from Virginia Council on Economic Education for: “Center for Economic Education.” Dunick will use this funding to support the continuation of the services of the Center for Economic Education. The Center supports K-12 teachers who are teaching economics and personal finance in Virginia. This grant represents the renewal of a long-standing relationship with the ...

FOR IMMEDIATE RELEASE Media Contacts: Colleen McDonald Sr. Consultant, Earned Media Kara Reed Director of Development Lisa Babin Executive Director of Communications Medical College of Wisconsin University of California San Diego LSU Health Shreveport  414.801.3146 | cmcdonald@mcw.edu 217.390.6629 | k3hendrickson@ucsd.edu 318.675.8769 | lisa.babin@lsuhs.edu   Milwaukee, Wis., August 27, 2024 – John McCorvy, PhD, Assistant Professor in the Department ...