Semaglutide and opioid overdose risk in patients with type 2 diabetes and opioid use disorder

JAMA Network Open

2024-09-25

(Press-News.org) About The Study: In this study, semaglutide was associated with reduced opioid overdose risk in patients with comorbid type 2 diabetes and opioid use disorder, suggesting its potential therapeutic value for preventing overdoses. The results need validation from other data resources and study populations. Further research is warranted to investigate the underlying mechanisms and randomized clinical trials are necessary to corroborate the clinical effects on opioid use disorder.

Corresponding Authors: To contact the corresponding authors, email Rong Xu, PhD, (rxx@case.edu) and Nora D. Volkow, MD, (nvolkow@nida.nih.gov).

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamanetworkopen.2024.35247)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

# # #

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2024.35247?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=092524

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

END

ELSE PRESS RELEASES FROM THIS DATE:

Bronze age lactobacillus genomes clarify kefir history

2024-09-25

Food fermentation is the oldest production practice using microorganisms in human history. Milk fermentation, for example, can be traced back to 6000–4000 BC in India, and Mediterranean populations produced and consumed cheese as early as 7000 before present (BP). Despite the long history of human consumption of fermented products, though, little has been known about the history of the use of fermentative microorganisms and the history of related cultural transmission. In particular, the evolutionary trajectories, especially functional adaptation, of these ...

Higher doses of buprenorphine may improve treatment outcomes for people with opioid use disorder

2024-09-25

Adults with opioid use disorder who receive a higher daily dose of the opioid addiction treatment medication buprenorphine may have a lower risk of subsequent emergency department visits or use of inpatient services related to behavioral health (such as for mental health and substance use disorders) than adults receiving the recommended dose, according to an analysis funded by the National Institutes of Health (NIH). These findings suggest that higher buprenorphine doses could be more effective in managing opioid use disorder, which may be particularly relevant for improving treatment for those who use fentanyl, a major ...

One in two El Niño events could be extreme by mid-century

2024-09-25

With the climate pattern known as El Niño in full force from mid-2023 to mid-2024, global temperatures broke records for 12 months in a row. As one of the strongest El Niño events on record, it was likely the main culprit of unprecedented heat, floods and droughts worldwide. In a new study published Sep. 25 in the journal Nature, a University of Colorado Boulder climate scientist and collaborators reveal that the planet could see more frequent extreme El Niño events by 2050 if greenhouse gas emissions continue to increase. “It’s ...

Bacterial ‘flipping’ allows genes to assume different forms

2024-09-25

Imagine being one cartwheel away from changing your appearance. One flip, and your brunette locks are platinum blond. That’s not too far from what happens in some prokaryotes, or single-cell organisms, such as bacteria, that undergo something called inversions. A study led by scientists at Stanford Medicine has shown that inversions, which cause a physical flip of a segment of DNA and change an organism’s genetic identity, can occur within a single gene, challenging a central dogma of biology — that one gene can code ...

Gladstone presents inaugural Sobrato prize in neuroscience to Yadong Huang, a pioneer of Alzheimer’s research

2024-09-25

Gladstone Institutes has established a new scientific award, the Sobrato Prize in Neuroscience, to advance breakthroughs in brain research with high potential for patient impact—and announced it will present the inaugural prize to Yadong Huang, MD, PhD, a trailblazer in Alzheimer’s research. In his nearly three decades at Gladstone, Huang has led a series of pioneering studies on the genetic underpinnings of Alzheimer’s disease, with discoveries that have opened multiple new avenues for drug development. He ...

Manganese cathodes could boost lithium-ion batteries

2024-09-25

Rechargeable lithium-ion batteries are growing in adoption, used in devices like smartphones and laptops, electric vehicles, and energy storage systems. But supplies of nickel and cobalt commonly used in the cathodes of these batteries are limited. New research led by the Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) opens up a potential low-cost, safe alternative in manganese, the fifth most abundant metal in the Earth’s crust. Researchers showed that manganese can be effectively used in emerging cathode materials called disordered rock salts, or DRX. Previous research suggested that to perform well, DRX materials had to be ground down to nanosized ...

To make fluid flow in one direction down a pipe, it helps to be a shark

2024-09-25

Link to Google Drive folder containing images: https://drive.google.com/drive/folders/1ZTBXkIFqwl_OyIMrUA1se_iv7hqEm_52?usp=sharing Link to release: https://www.washington.edu/news/2024/09/25/tesla-coil-shark-intestines/ FROM: James Urton University of Washington 206-543-2580 jurton@uw.edu (Note: researcher contact information at the end) For immediate release Sept. 25, 2024 To make fluid flow in one direction down a pipe, it helps to be a shark Flaps perform essential jobs. From pumping hearts to revving engines, flaps help fluid flow in one direction. ...

Growing divide: Rural men are living shorter, less healthy lives than their urban counterparts

2024-09-25

Rural men are dying earlier than their urban counterparts, and they’re spending fewer of their later years in good health, according to new research from the USC Schaeffer Center for Health Policy & Economics. Higher rates of smoking, obesity and cardiovascular conditions among rural men are helping fuel a rural-urban divide in illness, and this gap has grown over time, according to the study published this week in the Journal of Rural Health. The findings suggest that by the time rural men reach age 60, there are limited opportunities to fully address this disparity, and earlier interventions may be needed to prevent it from widening ...

During NY Climate Week, Alex Zhavoronkov PhD, Founder and CEO of Insilico Medicine, talks about Gen AI applications in drug discovery, longevity and climate change solutions at AWS Climate Tech & AI F

2024-09-25

Held annually, NY Climate Week is a pivotal event in the global climate change calendar. Bringing together notable leaders, celebrities, climate professionals, and innovators from around the world, the event serves as a critical platform for discussing and advancing climate action. This year’s theme, "It’s Time," underscores the urgency for immediate and ambitious efforts to tackle climate change, and the process could be accelerated with Generative AI and other cutting-edge technologies. Insilico Medicine ...

First genome-wide comparison of vapers and smokers finds similar DNA changes linked to disease risk

2024-09-25

Young adults who vape show chemical changes in their DNA similar to those found in young adults who smoke — changes known to be linked to the development of cancer — according to a new study just published in the American Journal of Respiratory Cell and Molecular Biology. A team of researchers from the Keck School of Medicine of USC measured DNA methylation, a chemical modification of DNA that can effectively turn genes “on” or “off, in the oral cells of young adult vapers, smokers and non-users. DNA methylation is vital to normal cellular ...

LAST 30 PRESS RELEASES:

Pigs may be transmission route of rat hepatitis E to humans

The Foundation of Consortium of Multiple Sclerosis Centers (FCMSC) receives $100,000 gift for the June Halper MS Nursing Scholarship Fund

Effects of transjugular intrahepatic portosystemic shunt on renal and pulmonary function in hepatic decompensation with and without hepatorenal and hepatopulmonary syndromes

During NY Climate Week, Alex Zhavoronkov PhD, Founder and CEO of Insilico Medicine, talks about Gen AI applications in drug discovery, longevity and climate change solutions at AWS Climate Tech & AI F