Alzheimer disease as a clinical-biological construct— an international working group recommendation

JAMA Neurology

2024-11-01

(Press-News.org) About The Study: This article discusses a recent revision of the Alzheimer Association criteria to define Alzheimer disease (AD) as a purely biological entity, which raises concerns that if diagnosis of AD can be reduced to the sole presence of AD core 1 biomarkers, major uncertainty and variability in the clinical prognosis of patients diagnosed with AD may be introduced.

Corresponding Author: To contact the corresponding author, Bruno Dubois, MD, MSc, email bruno.dubois@aphp.fr.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamaneurol.2024.3770)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

# # #

Media advisory: This study is being presented at the 17th Clinical Trials on Alzheimer’s Disease conference.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/jamaneurol.2024.3770?guestAccessKey=5d249549-8367-4844-b4c4-b4b21eac4863&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=110124

END

ELSE PRESS RELEASES FROM THIS DATE:

Press registration now open for the EULAR 2025 Congress in Barcelona

2024-11-01

The EULAR 2025 Congress will gather the world's foremost rheumatology experts, fostering a unique environment to explore pioneering research, clinical advancements, and patient-centred innovations in rheumatology. This annual flagship event offers unparalleled access to transformative discussions and showcases the latest strides in patient care for rheumatic and musculoskeletal diseases (RMDs). This year's Congress programme promises an impressive line-up, featuring must-see scientific sessions, EULAR Recommendations, and insightful abstract presentations. Esteemed speakers from across Europe and beyond ...

New research identifies ways to protect neurons from the negative effect of high-fat diet on multiple sclerosis progression

2024-11-01

NEW YORK, November 1, 2024 — Newly published research in the journal Glia has identified crucial links between dietary choices and the progression of multiple sclerosis (MS). The study, led by Patrizia Casaccia, founding director of the Advanced Science Research Center at the CUNY Graduate Center’s (CUNY ASRC) Neuroscience Initiative and Einstein Professor of Biology and Biochemistry at the CUNY Graduate Center, explored how enzymes called ceramide synthase 5 and 6 are responsible for the toxic effect ...

Boosting the nutritional value of black soldier fly larvae with biotechnology

2024-11-01

With the rapid increase in the global population, a "protein crisis" is expected in the near future, where the supply of protein will not be able to meet the rising demand. Fishmeal is the most common protein source that supports the production of livestock and aquaculture products, which are key protein sources for human consumption. However, global shortage of fishmeal and its rising prices have created an urgent need to find and secure an alternative protein source. Insects are gaining attention as novel protein sources ...

Medication decisions in pregnancy: A balancing act

2024-11-01

Most women use medication during pregnancy. Yet, selecting appropriate drugs and doses is challenging. In a new The Lancet article, physicians and researchers from the Radboud university medical center, Maastricht UMC+, Imperial College London, and the University of Liverpool introduce a shared decision-making approach combining ethical principles and a pregnant woman’s values with existing evidence. They use the example of sertraline, a commonly prescribed antidepressant in pregnancy, to illustrate the advocated decision-making process. Although pregnant women often need medication, data on drug safety and efficacy in pregnancy remains limited. Historically seen as vulnerable research ...

Texas Tech researcher named Station Science Leader for Antarctica project

2024-10-31

Summary: Texas Tech’s Natasja van Gestel has been named Station Science Leader by the National Science Foundation (NSF), enabling her to lead and coordinate research at Antarctica’s Palmer Station while advancing her work on climate change’s impact on glaciers. As a leader, she will oversee multiple scientific initiatives, manage resources and ensure compliance with the Antarctic Treaty’s regulations. Why This Matters: Climate Study: Her research contributes vital data on climate change effects in Antarctica, crucial for global climate assessments. International Collaboration: ...

Restricting sugar consumption in utero and in early childhood significantly reduces risk of midlife chronic disease

2024-10-31

A low-sugar diet in utero and in the first two years of life can meaningfully reduce the risk of chronic diseases in adulthood, a new study has found, providing compelling new evidence of the lifelong health effects of early-life sugar consumption. Published in Science, the study finds that children who experienced sugar restrictions during their first 1,000 days after conception had up to 35% lower risk of developing Type 2 diabetes and as much as 20% less risk of hypertension as adults. Low sugar intake by the mother prior to birth was enough to lower risks, but ...

Apixaban vs aspirin in patients with cancer and cryptogenic stroke

2024-10-31

New Orleans - Ochsner Health physicians Dr. Richard Zweifler and Dr. Joseph Tarsia are co-authors on a post hoc analysis carried out in the ARCADIA randomized clinical trial, comparing the effectiveness of apixaban versus aspirin in preventing adverse clinical outcomes in patients with a history of cancer and cryptogenic stroke. The research found no significant difference in the risk of major ischemic and hemorrhagic events between those taking apixaban and aspirin. The ...

Can magnetic pulses aimed at the brain treat insomnia?

2024-10-31

Traditional solutions for sleep disorders, including medications and cognitive behavioral therapies, often provide insufficient relief for military personnel, a problem researchers from the University of Arizona College of Medicine – Tucson will be hoping to solve with a $3 million grant from the Department of Defense Congressionally Directed Medical Research Program. Sleep problems are among the top health concerns of military personnel, with an estimated 85% meeting criteria for a clinically relevant sleep ...

F.M. Kirby Research Center honors 25 years of pioneering brain imaging research

2024-10-31

BALTIMORE, October 31, 2024— Kennedy Krieger Institute is proud to celebrate the 25th anniversary of the F.M. Kirby Research Center for Functional Brain Imaging at Kennedy Krieger Institute, a leader in advancements and research in understanding the human brain. Established in 1999 in partnership with Johns Hopkins University School of Medicine, the center has transformed neuroscience and medical imaging by developing cutting-edge magnetic resonance imaging (MRI) techniques that allow researchers to examine and measure brain function and structure ...

$1.75M CDC grant funds study to boost vaccine acceptance in Arizona’s rural, border communities

2024-10-31

Researchers at the University of Arizona’s Mel and Enid Zuckerman College of Public Health received a $1.75 million Centers for Disease Control and Prevention grant to conduct a community-based, participatory research study designed to improve vaccine uptake in Arizona’s rural and border communities. Vaccination is a highly effective public health intervention that saves millions of lives per year, yet vaccination rates have declined in recent years for a variety of reasons, ranging from safety concerns to religious and philosophical objections. “Vaccination is a cornerstone of public health,” said co-principal investigator Tomas ...

LAST 30 PRESS RELEASES:

The Lancet: Deeply entrenched racial and geographic health disparities in the USA have increased over the last two decades—as life expectancy gap widens to 20 years

Mass General Brigham and BIDMC researchers unveil an AI protein engineer capable of making proteins ‘better, faster, stronger’

Metabolic and bariatric surgery safe and effective for patients with severe obesity

Smarter city planning: MSU researchers use brain activity to predict visits to urban areas

Using the world’s fastest exascale computer, ACM Gordon Bell Prize-winning team presents record-breaking algorithm to advance understanding of chemistry and biology