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Case Western Reserve University awarded $1.5 million to study vaginal bacterial linked to serious health risks

Case Western Reserve University awarded $1.5 million to study vaginal bacterial linked to serious health risks
2024-11-25
(Press-News.org) CLEVELAND—Bacterial vaginosis (BV), the most prevalent condition affecting the female reproductive system in women aged 15 to 44, is linked to such serious health risks as preterm birth, gynecological malignancies and sexually transmitted diseases.

But effective long-term treatments for BV are limited: More than half experience a recurrence within six months, according to several studies.

With a $1.5 million grant from the National Institutes of Health (NIH), researchers at the Case Western Reserve School of Medicine will study the dynamics of BV in hopes of identifying a more effective approach.

“We hope to gain insights into promoting health within the human microbiome and to find better ways to prevent and treat infections that involve multiple types of bacteria,” said Gina Lewin, assistant professor in the Department of Pathology at the School of Medicine. “This research is a promising step toward better treatments for BV and highlights Case Western Reserve’s commitment to advancing women’s health.”

BV, which causes pain, odor and discharge—in addition to possible serious health risks—occurs from an imbalance in vaginal bacteria.

Lewin and her team of microbial ecologists—also part of Case Western Reserve’s Center for Global Health and Diseases—will investigate the diversity of bacteria in the vaginal microbiome at a single-cell level. They will focus on the different strains of bacteria present and their individual behaviors.

Lewin’s approach will examine the genetic variations within thousands of bacterial cells from vaginal microbiome, which could lead to understanding how BV develops and why some women respond better to treatment than others. This aspect of the study will work with established patient groups in collaboration with researchers at the University of Manitoba, Canada.

In addition, researchers will examine how individual bacterial cells behave and interact with a host environment, using advanced sequencing technology.

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At Case Western Reserve, one of the nation's leading research universities, we're driven to seek knowledge and find solutions to some of the world's most pressing problems. Nearly 6,200 undergraduate and 6,100 graduate students from across 96 countries study in our more than 250 degree programs across arts, dental medicine, engineering, law, management, medicine, nursing, science and social work. Our location in Cleveland, Ohio—a hub of cultural, business and healthcare activity—gives students unparalleled access to engaging academic, research, clinical, entrepreneurial and volunteer opportunities and prepares them to join our network of 125,000+ alumni making an impact worldwide. Visit case.edu to learn more.

 

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Case Western Reserve University awarded $1.5 million to study vaginal bacterial linked to serious health risks

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[Press-News.org] Case Western Reserve University awarded $1.5 million to study vaginal bacterial linked to serious health risks