PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Disease severity staging system for NOTCH3-associated small vessel disease, including CADASIL

JAMA Neurology

2024-11-29
(Press-News.org)

About The Study: The findings of this study suggest the NOTCH3-associated small vessel disease (NOTCH3-SVD) staging system will help to better harmonize NOTCH3-SVD and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) cohort studies and registries; may improve individualized disease counseling, monitoring, and clinical management; and may facilitate patient stratification in clinical trials.

Corresponding Authors: To contact the corresponding authors, email Gido Gravesteijn, MD, PhD (g.gravesteijn@lumc.nl) and Saskia A. J. Lesnik Oberstein, MD, PhD (lesnik@lumc.nl).

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamaneurol.2024.4487)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/jamaneurol.2024.4487?guestAccessKey=1159cb3b-9fd9-47ed-89c3-ffc0051dcb01&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=112924

END



ELSE PRESS RELEASES FROM THIS DATE:

Satellite evidence bolsters case that climate change caused mass elephant die-off

2024-11-29
A new study led by King’s College London has provided further evidence that the deaths of 350 African elephants in Botswana during 2020 were the result of drinking from water holes where toxic algae populations had exploded due to climate change. The lead author of the report says their analysis shows animals were very likely poisoned by watering holes where toxic blooms of blue-green algae, or cyanobacteria, had developed after a very wet year followed a very dry one. Davide Lomeo, a PhD student in the Department of Geography at King’s College London and co-supervised by Plymouth Marine Laboratory (PML) and ...

Unique killer whale pod may have acquired special skills to hunt the world’s largest fish

Unique killer whale pod may have acquired special skills to hunt the world’s largest fish
2024-11-29
Killer whales can feed on marine mammals, turtles, and fish. In the Gulf of California, a pod might have picked up new skills that help them hunt whale sharks – the world’s largest fish, growing up to 18 meters long. Whale sharks feed at aggregation sites in the Gulf of California, sometimes while they are still young and smaller. During this life-stage, they are more vulnerable to predation, and anecdotal evidence suggests orcas could be hunting them. Now, researchers in Mexico have reported four separate hunting events. “We show how orcas displayed a collaboratively hunting technique on whale sharks, characterized by ...

Emory-led Lancet review highlights racial disparities in sudden cardiac arrest and death among athletes

2024-11-29
UNDER STRICT EMBARGO UNTIL 6:30 PM November 28, 2024: A recent major review of data published by the Lancet and led by Emory sports cardiologist Jonathan Kim, MD, shows that Black athletes are approximately five times more likely to experience sudden cardiac arrest (SCA) and sudden cardiac death (SCD) compared to White athletes, despite some evidence of a decline in rates of SCD overall. SCA and SCD have historically been a leading cause of mortality among athletes, particularly those involved in high-intensity sports. The disparities in SCA/D rates highlights the need for increased research into the social determinants of health in younger athletes, a topic that remains ...

A new approach to predicting malaria drug resistance

A new approach to predicting malaria drug resistance
2024-11-28
Researchers at University of California San Diego analyzed the genomes of hundreds of malaria parasites to determine which genetic variants are most likely to confer drug resistance. The findings, published in Science, could help scientists use machine learning to predict antimalarial drug resistance and more effectively prioritize the most promising experimental treatments for further development. The approach could also help predict treatment resistance in other infectious diseases, and even cancer. “A lot of drug resistance research can only look at one chemical agent at a time, but what we’ve been able to do here is create a roadmap ...

Coral adaptation unlikely to keep pace with global warming

Coral adaptation unlikely to keep pace with global warming
2024-11-28
Coral adaptation to ocean warming and marine heatwaves will likely be overwhelmed without rapid reductions of global greenhouse gas emissions, according to an international team of scientists. Their study, led by Dr. Liam Lachs of Newcastle University, reveals that coral heat tolerance adaptation via natural selection could keep pace with ocean warming, but only if Paris Agreement commitments are realised, limiting global warming to two degrees Celsius. “The reality is that marine heatwaves are triggering mass coral bleaching mortality events across the world’s shallow tropical reef ecosystems, and the increasing frequency and intensity of these events ...

Bioinspired droplet-based systems herald a new era in biocompatible devices

Bioinspired droplet-based systems herald a new era in biocompatible devices
2024-11-28
UNDER EMBARGO UNTIL 19:00 GMT / 14:00 ET THURSDAY 28 NOVEMBER 2024 Bioinspired droplet-based systems herald a new era in biocompatible devices Oxford University researchers have developed a set of biocompatible devices, which can replicate or surpass many electronic functions but use ions as the signal carriers. The ‘dropletronic devices’ are made from miniature soft hydrogel droplets and can be combined to produce diodes, transistors, reconfigurable logic gates, and memory storage devices that mimic biological synapses. The research team generated a biocompatible, dropletronic ...

A fossil first: Scientists find 1.5-million-year-old footprints of two different species of human ancestors at same spot

A fossil first: Scientists find 1.5-million-year-old footprints of two different species of human ancestors at same spot
2024-11-28
More than a million years ago, on a hot savannah teeming with wildlife near the shore of what would someday become Lake Turkana in Kenya, two completely different species of hominins may have passed each other as they scavenged for food. Scientists know this because they have examined 1.5-million-year-old fossils they unearthed and have concluded they represent the first example of two sets of hominin footprints made about the same time on an ancient lake shore. The discovery will provide more insight into human evolution and how species cooperated and competed with ...

The key to “climate smart” agriculture might be through its value chain

2024-11-28
In 2023, the United Nations climate conference (COP28) officially recognized the importance of agriculture in influencing and mitigating climate change. In a Policy Forum, Johan Swinnen and colleagues offer an approach to overcome challenges related to improving climate-sensitive farming practices across the globe. They discuss the importance of working with Agricultural Value Chains (AVC) by incentivizing small businesses who play an important role in the support of small- and medium-sized farms. This would involve both upstream enterprises related to seeds, fertilizer, ...

These hibernating squirrels could use a drink—but don’t feel the thirst

2024-11-28
The thirteen-lined ground squirrel doesn’t drink during its winter hibernation, even though systems throughout its body are crying out for water. Madeleine Junkins and colleagues now show that the squirrel suppresses the need to quench its thirst by reducing the activity of a set of neurons in highly vascularized brain structures called circumventricular organs, which act as a specialized connection point between brain, blood circulation and cerebrospinal fluid. The study by Junkins et al. helps explain how some hibernating animals ignore the powerful physiological drive to seek out water ...

New footprints offer evidence of co-existing hominid species 1.5 million years ago

2024-11-28
Newly discovered footprints show that at least two hominid species were walking through the muddy submerged edge of a lake in Kenya’s Turkana Basin at the same time, about 1.5 million years ago. The find from the famous hominid fossil site of Koobi Fora described by Kevin Hatala and colleagues provides physical evidence for the co-existence of multiple hominid lineages in the region—something that has only been inferred previously from overlapping dates for scattered fossils. Based on information on gait and stance gleaned from the footprints, Hatala et al. think that the two species were Homo erectus and Paranthropus ...

LAST 30 PRESS RELEASES:

People on Ozempic who eat to regulate emotions less likely to lose weight

AACR Cancer Progress Report highlights lifesaving impact of federal investments in cancer research

Indra's internet

Lymph nodes found to be key to successful cancer immunotherapy

Room-temperature terahertz device opens door to 6G networks

A hard look at geoengineering reveals global risks

When smoke signals danger: How Australian lizards evolved to escape fire

Beyond the surface: Atopic eczema linked to significantly higher risk of suicidal thoughts, major study finds

After weight loss regular exercise rather than GLP-1 weight-loss drug reduces leading cause of heart attack and strokes

EASD launches its first ever clinical practice guideline – the world’s first to focus on diabetes distress

Semaglutide provides powerful protection against diabetic retinopathy, the leading cause of blindness in working-age adults, Greek study suggests

Orforglipron taken orally once daily leads to significant body weight loss (ATTAIN-1 Study)

U of I researchers trace genetic code’s origins to early protein structures

Disease experts team up with Florida Museum of Natural History to create a forecast for West Nile virus

Researchers: Targeted efforts needed to stem fentanyl crisis

New UMaine research could help lower prescription drug costs

Molecular movie shows how mitochondria read their DNA

Loss of key male fertility gene leads to changes in expression of hundreds of other genes

Water’s density is key to sustainable lithium mining

Pioneering research reveals problem gambling quadruples the risk of suicide among young people four years later

New method improves the accuracy of machine-learned potentials for simulating catalysts

Astronomers discover rare Einstein cross with fifth image, revealing hidden dark matter

UCalgary researchers show brain shunts significantly benefit older adults with hydrocephalus

UCalgary researchers pursue new approach to manage deadly lung scarring

Psychotherapy can be readily integrated into brief “med-check” psychiatry visits

‘Wiggling’ atoms may lead to smaller, more efficient electronics

Alliance webinar highlights latest advances in cancer treatment

Climate change could drastically reduce aquifer recharge in Brazil

$1.7M DOD grant funds virtual cancer center to support research into military health

Brain organoids could unlock energy-efficient AI

[Press-News.org] Disease severity staging system for NOTCH3-associated small vessel disease, including CADASIL
JAMA Neurology