PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Fewer skin ulcers in Werner syndrome patients treated with pioglitazone

“[…] the results of this study indicate that pioglitazone might be useful in treating refractory skin ulcers, a typical condition that reduces the quality of life of patients with WS”

Fewer skin ulcers in Werner syndrome patients treated with pioglitazone
2025-01-16
(Press-News.org)

“[…] the results of this study indicate that pioglitazone might be useful in treating refractory skin ulcers, a typical condition that reduces the quality of life of patients with WS.”

BUFFALO, NY- January 16, 2025 – A new research paper was published in Aging (listed by MEDLINE/PubMed as “Aging (Albany NY)” and “Aging-US” by Web of Science) Volume 16, Issue 22 on December 2, 2024, entitled “Less frequent skin ulcers among patients with Werner syndrome treated with pioglitazone: findings from the Japanese Werner Syndrome Registry.”

Scientists from Chiba University in Japan and other institutions have discovered that the drug pioglitazone, commonly used to treat diabetes, may help prevent painful skin ulcers in people with Werner syndrome. Werner syndrome is a rare genetic condition that causes people to age faster than normal, leading to early gray hair, cataracts, and other age-related health problems. One of the most serious complications is skin ulcers, which affect nearly 70% of people with the disorder and can lead to severe pain, infections, and even amputations.

The study, led by first author Kazuto Aono and corresponding author Masaya Koshizaka, looked at 51 patients with Werner syndrome from the Japanese Werner Syndrome Registry. Over half of the patients had skin ulcers, and those with ulcers were generally older and had higher blood pressure. The research team found that patients who took pioglitazone were much less likely to have ulcers, even after accounting for age.

The research suggests that pioglitazone’s ability to reduce inflammation helps wounds heal faster and prevents ulcers from forming. However, since the drug can cause side effects, like weaker bones, scientists recommend further studies to explore safer options, such as creams or gels made from pioglitazone that can be applied directly to the skin.

“Nanostructured hybrid materials loaded with pioglitazone are also being developed for clinical use and may be useful as wound dressings for ulcer treatment.” 

Although the study shows promising results, the authors emphasize that more long-term studies are needed to confirm how effective the treatment is besides the exploration of other factors, like diet and exercise, that may also help reduce the ulcers.

In conclusion, this study presents pioglitazone as a potential option to prevent skin ulcers in Werner syndrome patients. While further studies are needed, these findings provide hope for better treatments. 

Read the full paper: DOI: https://doi.org/10.18632/aging.206161

Corresponding author: Masaya Koshizaka, overslope@chiba-u.jp

Keywords: aging, Werner syndrome, skin ulcer, metformin, pioglitazon, progeroid syndrome

Click here to sign up for free Altmetric alerts about this article.

About Aging:

The journal Aging aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.)

Aging is indexed by PubMed/Medline (abbreviated as “Aging (Albany NY)”), PubMed Central, Web of Science: Science Citation Index Expanded (abbreviated as “Aging‐US” and listed in the Cell Biology and Geriatrics & Gerontology categories), Scopus (abbreviated as “Aging” and listed in the Cell Biology and Aging categories), Biological Abstracts, BIOSIS Previews, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science).

Please visit our website at www.Aging-US.com​​ and connect with us:

Facebook X Instagram YouTube LinkedIn Reddit Pinterest Spotify, and available wherever you listen to podcasts

Click here to subscribe to Aging publication updates.

For media inquiries, please contact media@impactjournals.com.

Aging (Aging-US) Journal Office
6666 E. Quaker St., Suite 1
Orchard Park, NY 14127
Phone: 1-800-922-0957, option 1

END


[Attachments] See images for this press release:
Fewer skin ulcers in Werner syndrome patients treated with pioglitazone Fewer skin ulcers in Werner syndrome patients treated with pioglitazone 2

ELSE PRESS RELEASES FROM THIS DATE:

Study finds surprising way that genetic mutation causes Huntington’s disease, transforming understanding of the disorder

Study finds surprising way that genetic mutation causes Huntington’s disease, transforming understanding of the disorder
2025-01-16
Scientists at the Broad Institute of MIT and Harvard, Harvard Medical School, and McLean Hospital have discovered a surprising mechanism by which the inherited genetic mutation known to cause Huntington’s disease leads to the death of brain cells. The findings change the understanding of the fatal neurodegenerative disorder and suggest potential ways to delay or even prevent it. For 30 years, researchers have known that Huntington’s is caused by an inherited mutation in the Huntingtin (HTT) gene, but they didn’t ...

DNA motors found to switch gears

DNA motors found to switch gears
2025-01-16
Scientists from Delft, Vienna, and Lausanne discovered that the protein machines that shape our DNA can switch direction. Until now, researchers believed that these so-called SMC motors that make loops into DNA could move in one direction only. The discovery, which is published in Cell, is key to understanding how these motors shape our genome and regulate our genes. Connecting DNA “Sometimes, a cell needs to be quick in changing which genes should be expressed and which ones should be turned off, for example in response to food, alcohol or heat. To turn genes off and on, cells use Structural Maintenance ...

Human ancestor thrived longer in harsher conditions than previous estimates

Human ancestor thrived longer in harsher conditions than previous estimates
2025-01-16
An early human ancestor of our species successfully navigated harsher and more arid terrains for longer in Eastern Africa than previously thought, according to a new study published in Nature Communications Earth & Environment. Homo erectus, the first of our relatives to have human-like proportions and the first known early human to migrate out of Africa, was the focus of the new study led by the international research team. The researchers analysed evidence from Engaji Nanyori in Tanzania’s Oldupai Gorge, revealing Homo erectus thrived ...

Evolution: Early humans adapted to extreme desert conditions over one million years ago

2025-01-16
Homo erectus was able to adapt to and survive in desert-like environments at least 1.2 million years ago, according to a paper published in Communications Earth & Environment. The findings suggest that behavioural adaptations included returning repeatedly over thousands of years to specific rivers and ponds for fresh water, and the development of specialised tools. The authors propose that this capability to adapt may have led to the expansion of H. erectus’ geographic range. There has been significant debate over ...

Race and ethnicity and diffusion of telemedicine in Medicaid for schizophrenia care after onset of the COVID-19 pandemic

2025-01-16
About The Study: In this cohort study of Medicaid beneficiaries with schizophrenia, telemental health care diffused rapidly after the onset of the COVID-19 pandemic, particularly in state-operated agencies. Together, agency-level and beneficiary-level race and ethnicity findings suggest within-agency racial and ethnic differences in diffusion of telemental health care. States should monitor the diffusion of innovations across vulnerable populations.  Corresponding Author: To contact the corresponding author, Sharon-Lise Normand, PhD, email sharon@hcp.med.harvard.edu. Embed this link to provide your readers free access to the full-text article This ...

Changes in support for advance provision and over-the-counter access to medication abortion

2025-01-16
About The Study: In this serial cross-sectional analysis of people ages 15 to 49 before Dobbs and 1 year after Dobbs, findings suggested that national support for expanded access to medication abortion has grown. Alternative models of care, such as advance provision and over-the-counter, have the potential to offer a promising approach to abortion care, particularly for people living in abortion-restricted states.  Corresponding Author: To contact the corresponding author, M. Antonia Biggs, PhD, email antonia.biggs@ucsf.edu. To access the embargoed study: Visit ...

Protein level predicts immunotherapy response in bowel cancer

2025-01-16
Francis Crick Institute press release Under strict embargo: 16:00hrs GMT Thursday 16 January 2025 Peer reviewed Observational study People and cells Protein level predicts immunotherapy response in bowel cancer Researchers at the Francis Crick Institute and Barts Cancer Institute, Queen Mary University of London, have shown that the amount of a protein called CD74 can indicate which people with bowel cancer may respond best to immunotherapy. If integrated into the clinic, testing for this protein could potentially allow hundreds of previously ineligible patients to benefit ...

The staying power of bifocal contact lens benefits in young kids

2025-01-16
COLUMBUS, Ohio – Young nearsighted kids who wear bifocal contact lenses that slow uncoordinated eye growth do not lose the benefits of the treatment once they stop wearing the lenses, new research shows. The study is a follow-up to a clinical trial published in 2020 showing that soft multifocal contact lenses with a heavy dose of added reading power dramatically slowed further progression of myopia in kids as young as 7 years old. Researchers wondered if discontinuing that treatment might cause a rebound of faster-than-normal eye growth that wipes out the benefit. In the new trial, nearsighted kids wore ...

Dose-dependent relationship between alcohol consumption and the risks of hepatitis b virus-associated cirrhosis and hepatocellular carcinoma: A meta-analysis and systematic review

Dose-dependent relationship between alcohol consumption and the risks of hepatitis b virus-associated cirrhosis and hepatocellular carcinoma: A meta-analysis and systematic review
2025-01-16
Background and Aims The quantitative effects of alcohol consumption on cirrhosis and hepatocellular carcinoma (HCC) in hepatitis B virus (HBV) infection are unknown. This study aimed to establish a dose-dependent model of alcohol consumption on the risks of cirrhosis and HCC. Methods PubMed, Embase, the Cochrane Library, Web of Science, and four Chinese databases were searched for studies published from their inception to 15 May 2024. A random-effects model was used to pool the data on the incidence of cirrhosis and HCC, and a dose-dependent model of alcohol’s effect on cirrhosis and HCC was established. Results A total of 33,272 HBV patients ...

International Alliance for Primary Immunodeficiency Societies selects Rockefeller University Press to publish new Journal of Human Immunity

International Alliance for Primary Immunodeficiency Societies selects Rockefeller University Press to publish new Journal of Human Immunity
2025-01-16
January 16, 2025 – New York, NY – The International Alliance for Primary Immunodeficiency Societies (IAPIDS) and Rockefeller University Press (RUP) have entered a partnership to launch Journal of Human Immunity (JHI), the official open access journal of IAPIDS. This collaboration will ensure that JHI emerges as the destination for exciting research into human immunity, with a particular focus on inborn errors of immunity. “The Journal of Human Immunity represents a bold step forward in advancing ...

LAST 30 PRESS RELEASES:

Pink skies

Monkeys are world’s best yodellers - new research

Key differences between visual- and memory-led Alzheimer’s discovered

% weight loss targets in obesity management – is this the wrong objective?

An app can change how you see yourself at work

NYC speed cameras take six months to change driver behavior, effects vary by neighborhood, new study reveals

New research shows that propaganda is on the rise in China

Even the richest Americans face shorter lifespans than their European counterparts, study finds

Novel genes linked to rare childhood diarrhea

New computer model reveals how Bronze Age Scandinavians could have crossed the sea

Novel point-of-care technology delivers accurate HIV results in minutes

Researchers reveal key brain differences to explain why Ritalin helps improve focus in some more than others

Study finds nearly five-fold increase in hospitalizations for common cause of stroke

Study reveals how alcohol abuse damages cognition

Medicinal cannabis is linked to long-term benefits in health-related quality of life

Microplastics detected in cat placentas and fetuses during early pregnancy

Ancient amphibians as big as alligators died in mass mortality event in Triassic Wyoming

Scientists uncover the first clear evidence of air sacs in the fossilized bones of alvarezsaurian dinosaurs: the "hollow bones" which help modern day birds to fly

Alcohol makes male flies sexy

TB patients globally often incur "catastrophic costs" of up to $11,329 USD, despite many countries offering free treatment, with predominant drivers of cost being hospitalization and loss of income

Study links teen girls’ screen time to sleep disruptions and depression

Scientists unveil starfish-inspired wearable tech for heart monitoring

Footprints reveal prehistoric Scottish lagoons were stomping grounds for giant Jurassic dinosaurs

AI effectively predicts dementia risk in American Indian/Alaska Native elders

First guideline on newborn screening for cystic fibrosis calls for changes in practice to improve outcomes

Existing international law can help secure peace and security in outer space, study shows

Pinning down the process of West Nile virus transmission

UTA-backed research tackles health challenges across ages

In pancreatic cancer, a race against time

Targeting FGFR2 may prevent or delay some KRAS-mutated pancreatic cancers

[Press-News.org] Fewer skin ulcers in Werner syndrome patients treated with pioglitazone
“[…] the results of this study indicate that pioglitazone might be useful in treating refractory skin ulcers, a typical condition that reduces the quality of life of patients with WS”