How prenatal alcohol exposure affects behavior into adulthood

Rodent study identifies a brain circuit that is disrupted by alcohol exposure during prenatal development and contributes to poor decision-making in adulthood

2025-02-03

(Press-News.org) Fetal alcohol spectrum disorders (FASD), characterized by symptoms of cognitive decline, such as worsened memory and impaired decision-making, are alarmingly prevalent globally. In a new study in JNeurosci led by Amy Griffin at the University of Delaware, researchers used rats to find brain circuits that may contribute to the cognitive issues that FASD patients experience, with the end goal of informing treatment strategies. Brain regions linked with working memory and decision-making were damaged in baby rats following exposure to alcohol during the age equivalent of the third trimester of pregnancy. After these rats aged into adulthood, Griffin and colleagues recorded from their brains while they performed tasks related to memory and decision-making. Rats showed impaired decision-making behaviors that were associated with disrupted communication between damaged brain regions. The researchers also developed a machine-learning algorithm that could accurately predict whether rats were exposed to alcohol or not based off their behavior alone. This study points to a brain circuit that is disrupted by third trimester alcohol exposure and contributes to FASD-like cognitive impairment in rats, which is informative for future research aiming to improve treatment strategies, according to the authors.

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Manuscript title: Choice Behaviors and Prefrontal-Hippocampal Coupling are Disrupted in a Rat Model of Fetal Alcohol Spectrum Disorders

Please contact media@sfn.org for full-text PDF

About JNeurosci

JNeurosci, the Society for Neuroscience's first journal, was launched in 1981 as a means to communicate the findings of the highest quality neuroscience research to the growing field. Today, the journal remains committed to publishing cutting-edge neuroscience that will have an immediate and lasting scientific impact, while responding to authors' changing publishing needs, representing breadth of the field and diversity in authorship.

About The Society for Neuroscience

The Society for Neuroscience is the world's largest organization of scientists and physicians devoted to understanding the brain and nervous system. The nonprofit organization, founded in 1969, now has nearly 35,000 members in more than 95 countries.

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