Impaired gastric myoelectrical rhythms associated with altered autonomic functions in patients with severe ischemic stroke
2025-03-17
(Press-News.org) Backgrounds and objectives
Gastrointestinal complications are common in patients after ischemic stroke. Gastric motility is regulated by gastric pace-making activity (also called gastric myoelectrical activity (GMA)) and autonomic function. The aim of this study was to evaluate GMA, assessed by noninvasive electrogastrography (EGG), and autonomic function, measured via spectral analysis of heart rate variability derived from the electrocardiogram in patients with ischemic stroke.
Methods
EGG and electrocardiogram were simultaneously recorded in both fasting and postprandial states in 14 patients with ischemic stroke and 11 healthy controls. Multi-channel surface EGG was used to measure GMA, and autonomic function was evaluated by heart rate variability spectral analysis.
Results
Compared to healthy subjects, patients with ischemic stroke, especially those with a modified Rankin scale ≥ 4, had impaired GMA in both fasting and postprandial states. This included a lower percentage of normal gastric slow waves (the basic rhythmic waves of GMA) and a higher percentage of tachygastria, bradygastria, or arrhythmia. Patients with ischemic stroke also showed a decrease in the dominant frequency and power of the gastric slow waves. Autonomic functions were altered in ischemic stroke patients with a modified Rankin scale ≥ 4, as reflected by increased sympathetic activity and reduced parasympathetic activity.
Conclusions
Gastric pace-making activity is impaired in patients with severe ischemic stroke, as evidenced by a reduced percentage of normal gastric slow waves and a lower frequency of gastric slow waves, likely due to impaired autonomic functions.
Full text
https://www.xiahepublishing.com/2994-8754/JTG-2024-00029
The study was recently published in the Journal of Translational Gastroenterology.
Journal of Translational Gastroenterology (JTG) dedicates to improving clinical diagnosis and treatment, advancing understanding of the molecular mechanisms, and promoting translation from bench to bedside of gastrointestinal, hepatobiliary, and pancreatic diseases. The aim of JTG is to provide a forum for the exchange of ideas and concepts on basic, translational, and clinical aspects of gastroenterology, and promote cross-disciplinary research and collaboration.
Follow us on X: @xiahepublishing
Follow us on LinkedIn: Xia & He Publishing Inc.
END
ELSE PRESS RELEASES FROM THIS DATE:
2025-03-17
The American College of Cardiology (ACC) has issued its first Concise Clinical Guidance (CCG) to create more streamlined and efficient processes to implement best practices in patient care. This CCG focuses on evaluating and managing cardiogenic shock (CS), addressing important questions around clinical decision-making and providing actionable guidance for health care providers.
“ACC has a long history of developing clinical policy to complement clinical practice guidelines and to inform clinicians about areas where evidence is new and evolving or where randomized data is more limited. Despite this, ...
2025-03-17
A new analysis led by surgeons at UCLA Health finds that psychological prehabilitation can significantly enhance recovery after surgery. The research, led by Anne E. Hall in the lab of Dr. Justine Lee analyzed data from 20 randomized controlled trials (RCTs) conducted between 2004 and 2024, involving a total of 2,376 patients. It is published in the Annals of Surgery
What is Psychological Prehabilitation? Prehabilitation is a proactive approach aimed at improving surgical outcomes through preventive measures. Traditionally, ...
2025-03-17
Trial of strength at the cellular level: cells are in constant competition with each other and so eliminate diseased or unwanted cells. Cell competition is therefore a central principle for maintaining the health of tissues and organs. Researchers have investigated the success factors of superior cells and discovered a previously unknown winning strategy in mechanical cell competition. They identified a variety in the ability of cells to exert mechanical forces onto other cells as the decisive regulator. With their results ...
2025-03-17
Milan, Italy – March 2025 – The Italian Association of Science Writers, SWIM, has announced an extension of the application deadline for the 2025 SWIM Award. Candidates now have until March 31, 2025, at 23:59 CET to submit their applications for the prestigious award, which has been recognizing excellence and innovation in science journalism in Italy since 2021.
The SWIM Award highlights the critical role of science journalists in fostering public understanding and dialogue on scientific issues. The competition also serves as the Italian selection process for the European ...
2025-03-17
On first inspection, the Cuban blue-headed quail dove doesn’t look like much: drab brown feathers, a slender beak, a pronounced strut in their walk typical of most other doves. You’d be forgiven for overlooking it in favor of Cuba’s prismatic parrots. But looks aren’t everything. For decades, this unassuming bird has perplexed biologists, who have no idea where it came from, how it got to the island or what it’s related to.
Now, for the first time, scientists have sequenced DNA from the blue-headed quail dove with the goal of finally getting to the bottom of things. Instead, they’re even more perplexed now than when they started.
“This ...
2025-03-17
The Vrije Universiteit Brussel (VUB) is opening 12 postdoctoral positions for international researchers, with a specific focus on American scholars working in socially significant fields. These prestigious fellowships come with substantial funding (€2.5 million) as part of the European Marie Skłodowska-Curie (MSCA) program. Additionally, as part of the Brains for Brussels initiative, VUB aims to actively attract American professors looking to relocate. In collaboration with its Francophone sister university ULB, VUB is also providing 18 apartments for international ...
2025-03-17
Researchers have widely accepted that what sets humans apart from nonhuman primates are prefrontal cortex–driven behaviors such as decision-making, reasoning, planning, and attention. In a new JNeurosci paper, research led by Rogier Mars, at University of Oxford, and Katherine Bryant, at Aix-Marseille University, provides a better picture of the cortical evolution that distinguishes human brains from other primates.
The researchers compared cortical organization not only between humans and macaques, which is a standard for human and nonhuman primate ...
2025-03-17
How stress impacts behavioral outcomes of traumatic brain injury (TBI) represents a major gap in knowledge. This oversight is especially felt by those in the military due to the high prevalence of TBI and the abundance of stress that they endure. In a study funded by the US Department of Defense, researchers led by Pamela VandeVord at Virginia Tech discovered that prior stress exposure influences TBI outcomes in a sex-dependent manner.
In their eNeuro paper, VandeVord and colleagues used an unpredictable stress paradigm ...
2025-03-17
MIAMI, FLORIDA (EMBARGOED UNTIL MARCH 17, 2025, AT NOON EDT) – Glioblastoma has remained one of the toughest cancers to treat, resisting even the latest advances in immunotherapy. But new research from Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine, suggests a way forward: suppressing a protein called ZNF638 triggers an antiviral immune response, making immune checkpoint inhibitors more effective. The discovery not only offers a potential new treatment strategy but also identifies ...
2025-03-17
In a randomized trial, Mass General Brigham researchers found the surgical removal of tonsils and adenoids was effective for children with snoring and mild sleep apnea
An estimated 6 to 17 percent of children have sleep-disordered breathing, ranging from snoring to sleep apnea, which can cause behavioral, neurocognitive, cardiovascular, and cardiometabolic issues. A new study from Mass General Brigham researchers reveals that adenotonsillectomy—the surgical removal of tonsils and adenoids—is an effective early intervention for these children. Their results are published in JAMA Pediatrics.
“To ...
LAST 30 PRESS RELEASES:
[Press-News.org] Impaired gastric myoelectrical rhythms associated with altered autonomic functions in patients with severe ischemic stroke
