A leap in canine medicine: Method for reproducible mesenchymal stem cells found

Using iPS cells, veterinary medicine has made a step forward in creating a stable MSC supply

2025-06-20

(Press-News.org) Mesenchymal stem cells (MSCs), which can be harvested from fat and bone marrow, have immune-modulating and anti-inflammatory effects that are beneficial for both human and veterinary medicine. However, MSCs have a limited proliferation capacity, with their quality varying depending on the donor’s age and where they were harvested from. For this reason, a method for producing MSCs using induced pluripotent stem cells (iPSCs) is attracting attention as a means to provide a stable supply of homogeneous MSCs. IPSCs have unlimited proliferation capacity and can be differentiated into various cell types. Despite this potential, there are only a limited number of studies focusing on dogs.

To improve canine medicine, a research team led by Professor Shingo Hatoya and Dr. Masaya Tsukamoto at Osaka Metropolitan University’s Graduate School of Veterinary Science has successfully generated iPSCs from four different types of canine somatic cells. Using these cells, the optimal method for producing canine MSCs was investigated.

By applying a method used for producing human MSCs, the research team successfully produced quality canine MSCs with high proliferation capacity and expressed MSC markers. Furthermore, when comparing four types of iPS cell-derived MSCs, it was found that the highest quality MSCs were obtained from urine cells.

“The establishment of a method for producing highly proliferative canine MSCs is expected to advance regenerative veterinary medicine,” stated Dr. Tsukamoto. Professor Hatoya concluded, “Going forward, we plan to conduct further verification of the immune regulatory and therapeutic effects of MSCs produced from canine iPS cells.”

###

About OMU

Established in Osaka as one of the largest public universities in Japan, Osaka Metropolitan University is committed to shaping the future of society through “Convergence of Knowledge” and the promotion of world-class research. For more research news, visit https://www.omu.ac.jp/en/ and follow us on social media: X, Facebook, Instagram, LinkedIn.

END

ELSE PRESS RELEASES FROM THIS DATE:

New nanoparticles offer safer, more effective drug delivery

2025-06-20

Scientists at Xi'an Jiaotong-Liverpool University (XJTLU) and Nanjing University in China have developed a new drug delivery system that could improve how treatments of cancers and other diseases are delivered. Their study, published in the journal ACS Applied Materials & Interfaces, describes a new type of nanoparticle made by combining a widely used medical polymer with a natural blood protein. These particles can carry much larger amounts of disease-fighting drugs and remain stable much ...

Virtual reality could help stroke survivors regain movement

2025-06-20

A Cochrane review has found that virtual reality (VR), when used in addition to standard therapy, can help stroke survivors regain arm movement. The findings suggests that VR could be a promising tool to boost rehabilitation efforts, particularly by increasing the amount of therapy patients receive. Published today, this is the fourth update of a Cochrane review first released in 2011, and now includes data from 190 trials involving 7,188 participants – with 119 new studies added since the previous version in 2017. The review assessed a wide range of VR technologies, ...

Placenta and hormone levels in the womb may have been key driver in human evolution, say researchers

2025-06-19

The placenta and the hormones it produces may have played a crucial role in the evolution of the human brain, while also leading to the behavioural traits that have made human societies able to thrive and expand, according to a new hypothesis proposed by researchers from the Universities of Cambridge and Oxford. Dr Alex Tsompanidis, senior researcher at the Autism Research Centre in the University of Cambridge, and the lead author of this new study, said: “Small variations in the prenatal levels of steroid hormones, like testosterone and oestrogen, can predict the rate of social and cognitive learning in infants and even ...

BMJ finds inaccuracies in key studies for AstraZeneca’s blockbuster heart drug ticagrelor

2025-06-19

In a follow up investigation into the multibillion dollar drug ticagrelor, The BMJ has uncovered fresh concerns, this time in key platelet studies used in its FDA approval. For more than a decade, ticagrelor (Brilinta in the US and Brilique in Europe) has been recommended for patients with acute coronary syndrome - a range of conditions related to sudden reduced blood flow to the heart. Last December, an investigation by The BMJ found serious data integrity problems in the landmark clinical trial (PLATO) that was used to ...

Paper outlines more efficient organic photoredox catalysis system inspired by photosynthesis

2025-06-19

EMBARGO: THIST CONTENT IS UNDER EMBARGO UNTIL 2 P.M. U.S. EASTERN STANDARD TIME ON JUNE 19, 2025. INTERESTED MEDIA MAY RECIVE A PREVIEW COPY OF THE JOURNAL ARTICLE IN ADVANCE OF THAT DATE OR CONDUCT INTERVIEWS, BUT THE INFORMATION MAY NOT BE PUBLISHED, BROADCAST, OR POSTED ONLINE UNTIL AFTER THE RELEASE WINDOW. Colorado State University researchers have published a paper in Science that describes a new and more efficient light-based process for transforming fossil fuels into useful modern chemicals. In it, they report that their organic ...

Plastic bag bans: Study finds up to 47% drop in shoreline bag litter

2025-06-19

Among the biggest culprits of plastic pollution in the ocean and along shorelines are thin plastic shopping bags, which have low recycling rates and often become litter when they blow away in the wind. Once there, they can entangle animals and break down into harmful microplastics. As awareness of this problem has grown, more than 100 countries have instituted bans or fees on plastic bags. But what effect those policies are having on the amount of plastic litter in the marine environment had not been systematically evaluated until now. A new study ...

Plastic bag policies are effective in reducing shoreline litter in the US

2025-06-19

Plastic bag regulations – bans and consumer fees – have led to meaningful reductions in plastic litter on U.S. shorelines, according to a new study. Plastic pollution has become a pervasive environmental issue; plastic debris comprises most of the marine litter worldwide and has been shown to pose serious threats to ocean life, ecosystems, and coastal economies. Much of this pollution originates from land and enters the ocean via rivers, wastewater, or wind. Among the most problematic ...

Current chemical monitoring data hinders global water risk evaluations

2025-06-19

A large-scale analysis of U.S. water quality data reveals that most toxic chemicals remain poorly characterized or undetected in routine monitoring. This is largely due to sparse risk assessment data, as well as detection limits that are too high to capture ecologically relevant concentrations, researchers report. The findings suggest that the true scale of chemical risk to biodiversity and ecosystems may be significantly underestimated. Chemical pollution is widely recognized as a major threat to biodiversity, human health, and the stability of ecosystems worldwide. However, the accelerating rate at which new chemicals are introduced into the environment outpaces the current ability ...

New method enables in vivo generation of CAR T cells to treat cancer and autoimmune disease

2025-06-19

Researchers present a new method to safely and preferentially generate CAR T cells directly inside the body using targeted lipid nanoparticles that deliver mRNA directly to T cells. The approach showed rapid and sustained immune reprogramming in preclinical models, highlighting its promise for treating cancer and autoimmune diseases. Adoptive immunotherapy, which harnesses a patient’s own immune cells to treat disease, holds immense therapeutic potential. Among its most prominent forms is CAR T cell therapy, in ...

Decline in population data collection threatens global public policy

2025-06-19

In a Policy Forum, Jessica Espey and colleagues argue that waning support for accurate collection and curation of population data worldwide threatens to compromise crucial evidence-based government planning. “We live in an era of seemingly unlimited data, where our digital activities may generate nearly constant information streams, yet some of our most essential infrastructure – demographic information – is deteriorating, introducing known and unknown bias into decision-making,” write the authors. ...

LAST 30 PRESS RELEASES:

New post-hoc analysis shows patients whose clinicians had access to GeneSight results for depression treatment are more likely to feel better sooner

Bimodal tactile tomography with bayesian sequential palpation for intracavitary microstructure profiling and segmentation

Disrupted connectivity of the brainstem ascending reticular activating system nuclei-left parahippocampal gyrus could reveal mechanisms of delirium following basal ganglia intracerebral hemorrhage

Cobalt single atom-phosphate functionalized reduced graphene oxide/perylenetetracarboxylic acid nanosheet heterojunctions for efficiently photocatalytic H2O2 production

[Press-News.org] A leap in canine medicine: Method for reproducible mesenchymal stem cells found
Using iPS cells, veterinary medicine has made a step forward in creating a stable MSC supply