Durotomy is a common neurosurgical complication involving a tear in the dura mater, the protective membrane surrounding the brain and spinal cord. Damage can cause cerebrospinal fluid (CSF) leakage, leading to delayed healing, headaches, and infection, making a reliable watertight dural closure essential.
Tissue adhesives are increasingly explored as alternatives to suturing for dural closure because they offer simpler and faster application. However, many existing glue-based sealants suffer from excessive swelling, leading to mass effect and unwanted tissue adhesion, which can lead to postoperative complications. To address these limitations, researchers have investigated Janus tissue patches, which feature two distinct surfaces—one that adheres strongly to tissue and another that prevents unwanted adhesion. Unfortunately, most existing Janus patches rely on multiple materials and complex, multi-step fabrication processes, limiting their practical use.
In a breakthrough study, a research team from South Korea led by Professor Seung Yun Yang from the Department of Biomaterials Science at Pusan National University has developed an innovative light-responsive, monolithic Janus dural patch using photocurable hyaluronic acid (HA) through a simple approach. “Made from natural biopolymer hyaluronic acid, our dural patch provides strong wet adhesion, along with a lubricating surface that prevents unwanted tissue adhesion, after exposure to non-toxic visible light,” explains Prof. Yang. Their study was made available online on December 16, 2025, and published in Volume 527 of Chemical Engineering Journal on January 01, 2026.
The researchers selected HA because of its excellent biocompatibility as well as its intrinsic anti-adhesive and lubricating properties. To enable light activation, HA was chemically modified with photocrosslinkable groups—methacrylate (MA) and 4-pentenoate (PA). The resulting HA-based solution was then lyophilized to form a patch with two distinct surfaces: a dense surface with a high polymer concentration and a porous surface with a lower polymer concentration. To further enhance conformal adhesion to wet tissues, the patch was compressed to a thickness of approximately 0.2 mm.
Laboratory tests showed that the patch could fully seal the wounds within five seconds using low-energy visible light. The dense outer surface exhibited strong wet adhesion, achieving high burst pressure and approximately 50% lower friction than conventional dural sealants. Notably, the adhesion strength was up to ten times higher than that of commercially available tissue adhesives. Meanwhile, the porous surface efficiently absorbed fluids and helped prevent unintended tissue adhesion. The patch also demonstrated minimal swelling and a reduced mass effect—less than 200% swelling and an approximately 0.1 g increase in weight—along with high stretchability, flexibility, and excellent biocompatibility.
The team also tested the developed patch in a rabbit durotomy model, where it achieved rapid and effective dural closure without causing damage to the surrounding skull, dura mater, or brain tissue. The photocurable dural patch has been transferred to biotech company SNvia, which has established large-scale manufacturing facilities for photocrosslinkable hyaluronic acid. Nonclinical studies are expected to conclude in the first half of 2026, with a medical device clinical trial application to South Korea’s Ministry of Food and Drug Safety planned for the same year.
Prof. Yang notes that the technology enables rapid wound sealing, reducing the risk of postoperative cerebrospinal fluid leakage. Importantly, the study provides practical evidence supporting the clinical safety and applicability of photocrosslinkable hyaluronic acid (HAMA-PA). Its strong adhesion to wet tissues also suggests broader potential for drug-delivery patches, cell-laden constructs, and artificial tissues.
Overall, this innovative dural patch holds great potential for use in diverse applications requiring rapid, watertight sealing.
***
Reference
DOI: 10.1016/j.cej.2025.171881
About Pusan National University
Pusan National University, located in Busan, South Korea, was founded in 1946 and is now the No. 1 national university of South Korea in research and educational competency. The multi-campus university also has other smaller campuses in Yangsan, Miryang, and Ami. The university prides itself on the principles of truth, freedom, and service and has approximately 30,000 students, 1,200 professors, and 750 faculty members. The university comprises 14 colleges (schools) and one independent division, with 103 departments in all.
Website: https://www.pusan.ac.kr/eng/Main.do
About SNvia Co., Ltd.
SNvia is a biotechnology company and a subsidiary of Pusan National University, focused on the manufacture of innovative medical products based on microneedle technologies and photocurable polymers, with more than nine years of experience in the field. SNvia’s photocurable therapeutic polymers (PhotoQ-HA®) are hyaluronic acid (HA)–based, medical-grade biomaterials produced in qualified manufacturing facilities. The development of photocurable HA is guided by principles of safety and biocompatibility, enabling a wide range of biomedical applications, including tissue adhesives, hemostatic agents, tissue-engineering scaffolds, bioinks for 3D printing, and drug-delivery carriers for long-term therapy.
Website: https://www.snvia.com
About the author
Dr. Seung Yun Yang is a Professor of Biomaterials Science at Pusan National University (PNU) and a polymer engineer specializing in functional biomaterials for drug delivery and tissue regeneration. He earned his PhD in Polymer Engineering from POSTECH in 2010 and completed postdoctoral training at Brigham and Women’s Hospital, Harvard Medical School. Since joining PNU, he has developed innovative medical devices using photocurable polymers and microneedle technologies to enhance drug delivery and promote tissue regeneration. He is also the founder of SNVIA Co., Ltd., where he leads research expansion and clinical translation while overseeing collaborations across international initiatives.
Lab: https://sites.google.com/site/syanglabpnu/
ORCID ID: 0000-0002-1233-8960
END