(Press-News.org) DURHAM, N.C. – When the eye’s drainage system clogs, pressure builds up and causes damage. The pressure can lead to glaucoma and vision loss.
New research, published March 9 in the journal Immunity, reveals that a specialized set of immune cells act as the cleanup crew, pointing to a promising new target for therapies to prevent a major cause of blindness.
These immune cells - known as resident macrophages - live in the eye’s drainage tissues. Until now, the role of resident macrophages in controlling eye pressure was unknown.
“The only way we can treat glaucoma is by lowering the eye pressure, yet we still have patients who go blind despite current treatments,” said Katy Liu, M.D., Ph.D., lead author of the study and assistant professor in the Department of Ophthalmology at Duke University School of Medicine.
“This research helps us understand the role of the immune system in regulating eye pressure,” Liu said.
In the study, researchers tracked fluorescently tagged resident macrophages in mouse eyes. When they selectively removed these cells, the eye’s drain became clogged, fluid built up, and eye pressure increased.
“Our findings show that resident macrophages are essential for maintaining healthy eye pressure,” said Liu. “Disruption of this system may contribute directly to the development of glaucoma.”
This discovery could lead to the development of future glaucoma treatments. The next step is to do research that identifies these resident macrophages in human eye tissue.
“Now we have a specific target for developing new therapies that can normalize the eye pressure and stop vision loss, in contrast to current medications that do not target the source of disease,” said W. Daniel Stamer, Ph.D., corresponding author, Joseph A.C. Wadsworth Distinguished Professor of Ophthalmology, and Co-Vice Chair for Basic Science Research.
The Duke Eye Center has a long history of breakthroughs in glaucoma, including research that led to FDA-approval of the first new drug to treat glaucoma in 20 years.
“This discovery is a major step forward in understanding how the immune system contributes to the regulation of eye pressure,” said Daniel Saban, Ph.D., co-corresponding author, Joseph A.C. Wadsworth Distinguished Professor of Ophthalmology, and Vice Chair of Research Strategy in the Department of Ophthalmology. “This research builds on Duke's strong history of turning laboratory findings into real treatments for patients.”
In addition to Liu, Saban and Stamer, study authors include Aleksander O. Grimsrud, Maria Fernanda Suarez, Darren Schuman, Michael L. De Ieso, Megan Kuhn, Ruth A. Kelly, Rose Mathew, Joan Kalnitsky, Matthias Mack, Gerasimos Anagnostopoulos, Florent Ginhoux, Violet Bupp-Chickering, Revathi Balasubramanian, and Simon W. M. John.
The study is funded by the National Institutes of Health (K08EY032202), Research to Prevent Blindness, the Duke Strong Start Award, the Heed Fellowship and the American Glaucoma Society.
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Photos, b-roll of Katy Liu, M.D., Ph.D. in lab: https://duke.app.box.com/s/3fbuz2m33icgjdezvi2wp2zsyhtiferp
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