(Press-News.org) Advanced hepatitis C patients with chronic liver disease may benefit from drinking coffee during treatment, according to a new study in Gastroenterology, the official journal of the American Gastroenterological Association (AGA) Institute. Patients who received peginterferon plus ribavirin treatment and who drank three or more cups of coffee per day were two times more likely to respond to treatment than non-drinkers.
"Coffee intake has been associated with a lower level of liver enzymes, reduced progression of chronic liver disease and reduced incidence of liver cancer," said Neal Freedman, PhD, MPH, of the National Cancer Institute and lead author of this study. "Although we observed an independent association between coffee intake and virologic response to treatment, this association needs replication in other studies."
Among non-drinkers, 46 percent had an early virologic response; 26 percent had no detectable serum hepatitis C virus (HCV) ribonucleic acid at week 20; 22 percent had no detectable serum at week 48; and 11 percent had a sustained virologic response. In contrast, the corresponding proportions for those who drank three or more cups of coffee per day were 73 percent, 52 percent, 49 percent and 26 percent, respectively.
Approximately 70 to 80 percent of individuals exposed to HCV become chronically infected. Worldwide, these individuals are estimated to number between 130 and 170 million. Higher coffee consumption has been associated with slower progression of pre-existing liver disease and lower risk of liver cancer. However, the relationship with response to anti-HCV treatment had not been previously evaluated. Treatment with peginterferon and ribavirin resolves chronic hepatitis C in about half of patients. It is unknown whether coffee will improve response with the addition of new drugs that were recently approved for use in the U.S.
Because patients in the Hepatitis C Antiviral Long-term Treatment against Cirrhosis Trial also had previously failed interferon therapy, it is not clear whether the results can be generalized to other patient populations. Future studies among patients with less advanced disease, those who are treatment-naïve to prior therapy, or who are being treated with newer antiviral agents are needed.
###
For more information on hepatitis, please read the AGA brochure "Understanding Hepatitis" at www.gastro.org/patient-center/digestive-conditions/hepatitis or visit the National Institute of Diabetes and Digestive and Kidney Diseases at http://digestive.niddk.nih.gov/ddiseases/pubs/hepc_ez.
About the AGA Institute
The American Gastroenterological Association is the trusted voice of the GI community. Founded in 1897, the AGA has grown to include 17,000 members from around the globe who are involved in all aspects of the science, practice and advancement of gastroenterology. The AGA Institute administers the practice, research and educational programs of the organization. www.gastro.org.
About Gastroenterology
Gastroenterology, the official journal of the AGA Institute, is the most prominent scientific journal in the specialty and is in the top 1 percent of indexed medical journals internationally. The journal publishes clinical and basic science studies of all aspects of the digestive system, including the liver and pancreas, as well as nutrition. The journal is abstracted and indexed in Biological Abstracts, Current Awareness in Biological Sciences, Chemical Abstracts, Current Contents, Excerpta Medica, Index Medicus, Nutrition Abstracts and Science Citation Index. For more information, visit www.gastrojournal.org.
Become an AGA fan on Facebook.
Join our LinkedIn group.
Follow us on Twitter @AmerGastroAssn.
Check out our videos on YouTube.
Coffee drinking improves hepatitis C treatment response
2011-06-08
ELSE PRESS RELEASES FROM THIS DATE:
Experts prove link between phosphate intake and heart disease
2011-06-08
Lowering phosphate intake in humans can reduce heart disease, according to research by experts at the University of Sheffield.
This is the first time the connection between a high phosphate diet and atherosclerosis - the cause of heart disease - has been proven. The findings have been published in Arteriosclerosis, Thrombosis and Vascular Biology (2 June 2011).
The research, which was funded by the Sheffield Kidney Association and the National Institute for Health Research, has shown that cholesterol deposits in the wall of arteries are increased following a higher ...
Women warriors show resilience similar to men
2011-06-08
WASHINGTON – Women service members who experience combat are apparently as resilient as the men they serve alongside, according to a study published by the American Psychological Association.
Men and women deployed to Iraq and Afghanistan in 2007 and 2008 experienced very similar levels of combat-related stress and post-deployment mental health impacts during the first year following return from deployment, researchers reported in the Journal of Abnormal Psychology, published by APA.
"Contrary to popular belief, women who go to war respond to combat trauma much like ...
Mammary gland development of blueberry-fed lab animals studied
2011-06-08
This release is available in Spanish.
U.S. Department of Agriculture (USDA)-funded studies of mammary gland development in laboratory rats fed blueberries or other foods of interest may aid breast cancer research.
In an early study that has paved the way to follow-up experiments, Rosalia C. M. Simmen of the Arkansas Children's Nutrition Center (ACNC) in Little Rock, Ark., has determined that several indicators of rat mammary gland health were improved in the offspring (pups) of mothers (dams) that had been fed 5 percent blueberry powder in their rations during pregnancy ...
Bacteria on old-growth trees may help forests grow
2011-06-08
A new study by Dr. Zoë Lindo, a post-doctoral fellow in the Department of Biology at McGill University, and Jonathan Whiteley, a doctoral student in the same department, shows that large, ancient trees may be very important in helping forests grow.
These findings highlight the importance of maintaining the large old-growth trees in the coastal temperate rainforests that stretch from Southern Alaska to Northern California. Lindo's findings suggest that it is the interactions between old trees, mosses and cyanobacteria, which contribute to nutrient dynamics in a way that ...
Overweight more harmful to the liver than alcohol in middle-aged men
2011-06-08
Overweight carries a greatly increased risk of cirrhosis of the liver in men, reveals a new study from the Sahlgrenska Academy. "Given the increasing problem of overweight in Sweden, there is reason to fear that more people will develop cirrhosis of the liver," says Jerzy Kaczynski, docent at the Sahlgrenska Academy and doctor at Sahlgrenska University Hospital.
A group of researchers at the Sahlgrenska Academy has studied the link between overweight and the risk of developing cirrhosis of the liver in middle-aged men. Published in the Scandinavian Journal of Gastroenterology, ...
Using magnets to help prevent heart attacks
2011-06-08
If a person's blood becomes too thick it can damage blood vessels and increase the risk of heart attacks. But a Temple University physicist has discovered that he can thin the human blood by subjecting it to a magnetic field.
Rongjia Tao, professor and chair of physics at Temple University, has pioneered the use of electric or magnetic fields to decrease the viscosity of oil in engines and pipelines. Now, he is using the same magnetic fields to thin human blood in the circulation system.
Because red blood cells contain iron, Tao has been able to reduce a person's blood ...
Carbon release and global warming now and in the ancient past
2011-06-08
The present rate of greenhouse carbon dioxide emissions through fossil fuel burning is higher than that associated with an ancient episode of severe global warming, according to new research. The findings are published online this week by the journal Nature Geoscience.
Around 55.9 million years ago, the Earth experienced a period of intense global warming known as the Palaeocene–Eocene Thermal Maximum (PETM), which lasted for around 170,000 years. During its main phase, average annual temperatures rose by around 5°C.
Scientists believe that the warming may have been ...
Innovative device for quantum simulations
2011-06-08
A team of researchers from Columbia Engineering, the Italian National Research Council, Princeton University, University of Missouri, and University of Nijmegen (Netherlands) has developed an artificial semiconductor structure that has superimposed a pattern created by advanced fabrication methods that are precise at the nanometer scale. The pattern is similar to the honeycomb lattice that occurs in graphene. The device, called "artificial graphene" (AG), simulates quantum behavior of strongly interacting electrons. The research team sees the AG-device as a first step towards ...
Dolphins use double sonar
2011-06-08
Dolphins and porpoises use echolocation for hunting and orientation. By sending out high-frequency sound, known as ultrasound, dolphins can use the echoes to determine what type of object the sound beam has hit.
Researchers from Sweden and the US have now discovered that dolphins can generate two sound beam projections simultaneously.
"The beam projections have different frequencies and can be sent in different directions. The advantage is probably that the dolphin can locate the object more precisely", says Josefin Starkhammar, a newly examined doctor in Electrical ...
Will the eel survive its management?
2011-06-08
The European eel is on the way to disappearing for good. The species is critically endangered, and there are strong scientific arguments for suspending all fishing. Despite this situation, Swedish eel fishery is allowed to continue. Analysis of the eel management plan by the Swedish Institute for the Marine Environment identifies clear shortcomings. It is unlikely that Sweden will meet the target that has been set for silver eels capable of migrating back to the Sargasso Sea so that they can contribute to regeneration.
The recruitment of new annual cohorts of European ...