PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

High rates of injection drug use in urban Aboriginal youth signal need for prevention programs

2011-06-14
(Press-News.org) A new study indicates high rates of injection drug use in urban Canadian Aboriginal youth, particularly in women, and points to the need for culturally specific prevention programs, states an article in CMAJ (Canadian Medical Association Journal) (pre-embargo link only) http://www.cmaj.ca/embargo/cmaj101257.pdf

Aboriginal leadership is alarmed at the levels of substance abuse in their young people, especially injection drug use, which is associated with HIV and hepatitis C virus infections. Injection drug use accounts for 70%󈞼% of all hepatitis C virus and almost 60% of HIV infections in Aboriginal youth under age 24 in Canada. The history of colonization, including the effect of residential schooling on several generations and the child welfare system, has had significant negative effects on Aboriginal communities. Many children and youth have experienced physical, sexual and emotional abuses as well as exposure to familial violence and drug dependence.

The Cedar Project is a prospective study of 605 Aboriginal youth in Vancouver and Prince George, British Columbia, conducted from 2003 to 2007 that sought to understand use of illicit drugs, particularly relating to infection with HIV. Participants were between the ages of 14 and 30 years and had smoked or injected illicit drugs, other than marijuana, in the month before enrolment. The median age was 23, and 292 (48.3%) were women.

At the start of the study, 335 (55.4%) of participants reported a history of injection drug use. Injection drug users were more likely to be women, to be older, to identify as gay, lesbian, bisexual or two-spirited, to have experienced sexual abuse, to have a parent who attended a residential school and to have other risk factors. In participants who had no history of injection drug use and who attended at least one follow-up visit (197 out of 270), 39 people (18 men, 21 women) began to inject drugs.

Young Aboriginal women were twice as likely to inject drugs as men.

"In our study population, about 11 participants per 100 person-years will transition to injection drug use — a rate that is almost twice as high as that found in the only other available longitudinal study done in Canada investigating transition to injection drug use among young people (6.8 per 100 person-years in Montréal, Quebec)," states Dr. Patricia Spittal, School of Population and Public Health, University of British Columbia, with coauthors. "Transition to injection drug use at a young age not only increases the risk of contracting an infectious disease, it also further entrenches the young person in an increasingly dangerous street life that often involves sex work, violence, predation and life-long addiction."

The study was conducted by researchers from the School of Population and Public Health, University of British Columbia; Simon Fraser University; the Centre for Health Evaluation and Outcome Sciences at Providence Health Care; the Wuikinuxv Nation, Port Hardy, BC; and the Splats'in/Secwepemc Nation, Enderby, BC.

"This study documents an unacceptable number of young, at-risk Aboriginal people transitioning to injection drug use every year; however, there are no prevention programs tailored specifically to this population," states Chief Wayne Christian and coauthors. "Support for community-based programs that address the potential for drug dependence within the context of sexual trauma should be prioritized to respond to the dual epidemics of injection drug use and blood-borne infection among Aboriginal people," they conclude.

### END


ELSE PRESS RELEASES FROM THIS DATE:

Health data can help address alcohol-related harm in youth

2011-06-14
Administrative information can be useful for surveillance and understanding of alcohol-related harm in young people, states an article in CMAJ (Canadian Medical Association Journal) (pre-embargo link only) http://www.cmaj.ca/embargo/cmaj110367.pdf Binge drinking and overconsumption of alcohol by young people is a growing issue in many countries. For example, in a 2009 study, almost 60% of young Canadians aged 15-24 reported having consumed alcohol in the previous month, with 22% reporting heaving drinking and 20% experiencing harm related to alcohol consumption. In Australia, ...

Safe prescribing information for children in Canada often hard to find

2011-06-14
Accurate, safe prescribing information for children is often unavailable to doctors in Canada because pharmaceutical companies will not disclose information to Health Canada, states an editorial in CMAJ (Canadian Medical Association Journal) (pre-embargo link only) http://www.cmaj.ca/embargo/cmaj110563.pdf Health professionals in Canada as well as other countries such as Japan and Australia, unlike their colleagues in the United States and Europe, do not have access to the same body of evidence regarding pediatric dosing. "As a consequence, Canadian children and youth ...

Glowing Cornell dots -- a potential cancer diagnostic tool set for human trials

2011-06-14
NEW YORK – The U.S. Food and Drug Administration (FDA) has approved the first clinical trial in humans of a new technology: Cornell Dots, brightly glowing nanoparticles that can light up cancer cells in PET-optical imaging. A paper describing this new medical technology, "Multimodal silica nanoparticles are effective cancer-targeted probes in a model of human melanoma," will be published June 13, 2011 in the Journal of Clinical Investigation (July 2011). This is a collaboration between Memorial Sloan-Kettering Cancer Center (MSKCC), Cornell University, and Hybrid Silica ...

More genetic diseases linked to potentially fixable gene-splicing problems

2011-06-14
PROVIDENCE, R.I. [Brown University] — A new Brown University computer analysis that predicts the effect of genetic mutations on how the body splices mRNA indicates as many as a third of disease-related mutations may be linked to splicing problems — more than double the proportion previously thought. "Something like 85 percent of the mutations in the Human Gene Mutation Database are presumed to affect how proteins are coded, but what this work shows is that 22 percent of those are affecting the splicing process," said William Fairbrother, assistant professor of biology ...

Decoding chronic lymphocytic leukemia

2011-06-14
A paper published online on June 13 in the Journal of Experimental Medicine (www.jem.org) identifies new gene mutations in patients with chronic lymphocytic leukemia (CLL)—a disease often associated with lack of response to chemotherapy and poor overall survival. CLL is the most common leukemia in the Western world, but the disease varies greatly from patient to patient with regard to prognosis, survival, and disease course. In attempt to understand the genetic basis for this heterogeneity, a group led by Riccardo Dalla-Favera at Columbia University and Gianluca Gaidano ...

NIH researchers find new clues about aging

2011-06-14
National Institutes of Health researchers have identified a new pathway that sets the clock for programmed aging in normal cells. The study provides insights about the interaction between a toxic protein called progerin and telomeres, which cap the ends of chromosomes like aglets, the plastic tips that bind the ends of shoelaces. The study by researchers from the National Human Genome Research Institute (NHGRI) appears in the June 13, 2011 early online edition of the Journal of Clinical Investigation. Telomeres wear away during cell division. When they degrade sufficiently, ...

Sniffing out a new source of stem cells

2011-06-14
A team of researchers, led by Emmanuel Nivet, now at the Salk Institute for Biological Studies, La Jolla, has generated data in mice that suggest that adult stem cells from immune system tissue in the smell-sensing region of the human nose (human olfactory ecto–mesenchymal stem cells [OE-MSCs]) could provide a source of cells to treat brain disorders in which nerve cells are lost or irreparably damaged. Stem cells are considered by many to be promising candidate sources of cells for the regeneration and repair of tissues damaged by various brain disorders (including traumatic ...

JCI online early table of contents: June 13, 2011

2011-06-14
EDITOR'S PICK: Sniffing out a new source of stem cells A team of researchers, led by Emmanuel Nivet, now at the Salk Institute for Biological Studies, La Jolla, has generated data in mice that suggest that adult stem cells from immune system tissue in the smell-sensing region of the human nose (human olfactory ecto–mesenchymal stem cells [OE-MSCs]) could provide a source of cells to treat brain disorders in which nerve cells are lost or irreparably damaged. Stem cells are considered by many to be promising candidate sources of cells for the regeneration and repair ...

Brain scan identifies patterns of plaques and tangles in adults with Down syndrome

Brain scan identifies patterns of plaques and tangles in adults with Down syndrome
2011-06-14
In one of the first studies of its kind, UCLA researchers used a unique brain scan to assess the levels of amyloid plaques and neurofibrillary tangles — the hallmarks of Alzheimer's disease — in adults with Down syndrome. Published in the June edition of the Archives of Neurology, the finding may offer an additional clinical tool to help diagnose dementia in adults with Down syndrome, a genetic disorder caused by the presence of a complete or partial extra copy of chromosome 21. Adults with this disorder develop Alzheimer's-like plaque and tangle deposits early, ...

Chillingham cattle cowed by climate change

Chillingham cattle cowed by climate change
2011-06-14
Spring flowers are opening sooner and songbirds breeding earlier in the year, but scientists know little about how climate change is affecting phenology – the timing of key biological events – in UK mammals. Now, a new study on Northumberland's iconic Chillingham cattle published in the British Ecological Society's Journal of Animal Ecology shows climate change is altering when these animals breed, and fewer calves are surviving as a result. The team of ecologists lead by Dr Sarah Burthe of the Centre for Ecology & Hydrology were able to use the cattle to discover more ...

LAST 30 PRESS RELEASES:

Cost-effective, high-capacity, and cyclable lithium-ion battery cathodes

Artificial intelligence enhances monitoring of threatened marbled murrelet

The solution to kidney bleeding and recovery lies within a hemostasis sponge, using the inherent capabilities of the kidneys

Sylvester Cancer adding cellular therapy to its arsenal against metastatic melanoma

Study finds biomarkers for psychiatric symptoms in patients with rare genetic condition 22q

Medical school scientist creates therapy to kill hypervirulent bacteria

New study supports psilocybin’s potential as an antidepressant

The Lancet Public Health: Global study reveals stark differences between females and males in major causes of disease burden, underscoring the need for gender-responsive approaches to health

Revealed: face of 75,000-year-old female Neanderthal from cave where species buried their dead

Hepatitis B is globally underassessed and undertreated, especially among women and Asian minorities in the West

Efficient stochastic parallel gradient descent training for on-chip optical processors

Liquid crystal-integrated metasurfaces for an active photonic platform

Unraveling the efficiency losses and improving methods in quantum dot-based infrared up-conversion photodetectors

A novel deep proteomic approach unveils molecular signatures affected by aging and resistance training

High-intensity spatial-mode steerable frequency up-converter toward on-chip integration

Study indicates that cancer patients gain important benefits from genome-matched treatments

Gift to UCR clinic aims to assist local unhoused population

Research breakthrough on birth defect affecting brain size

Researchers offer US roadmap to close the carbon cycle

Precipitation may brighten Colorado River’s future

Identifying risks of human flea infestations in plague-endemic areas of Madagascar

Archaea can be picky parasites

EPA underestimates methane emissions from landfills, urban areas

Feathers, cognition and global consumerism in colonial Amazonia

Satellite images of plants’ fluorescence can predict crop yields

Machine learning tool identifies rare, undiagnosed immune disorders through patients’ electronic health records

MD Anderson researcher Sharon Dent elected to prestigious National Academy of Sciences

Nonmotor seizures may be missed in children, teens

Emergency departments frequently miss signs of epilepsy in children

Unraveling the roles of non-coding DNA explains childhood cancer’s resistance to chemotherapy

[Press-News.org] High rates of injection drug use in urban Aboriginal youth signal need for prevention programs