Young researcher on the trail of herbal snakebite antidote

(Press-News.org) A PhD student at the University of Copenhagen has drawn on nature's own pharmacy to help improve the treatment of snakebites in Africa.

Marianne Molander from the University of Copenhagen's Faculty of Health and Medical Sciences has been working within a Danish team that has examined various plants native to the African continent in a bid to find locally available herbal antidotes.

"Snake venom antidotes are expensive, it's often a long way to the nearest doctor and it can be difficult to store the medicine properly in the warm climate. As a result many local people rely on natural resources for treating potentially fatal bites," says pharmacist and PhD student Marianne Molander.

The Danish researchers are now investigating African plants that have proven effective in treating snakebite. Armed with the results of their research they are set to provide guidance in the use of plants in remote areas where local people have limited access to Western medicine:

"We have particularly focused on the snake species Bitis arietans, which is widespread south of the Sahara. All snake venoms consist of a unique cocktail of enzymes, which results in rapid tissue death. Along with our African partners, we are currently testing plants that act as venom antidotes in remote regions of Africa. A hundred plants from Mali, 27 from South Africa and 13 from the Democratic Republic of Congo are now under the microscope," says Marianne Molander, PhD student in drug design and pharmacology at the University of Copenhagen.

Snake venom as medicine

100,000 people worldwide die each year from snakebites. Three times as many suffer permanent injuries, disability or amputations as a result of a bite to an arm or leg. The problem is greatest in tropical developing countries, where agricultural workers, women and children are the most likely victims. Although a million people in Africa are bitten by snakes each year - only half receive treatment.

But snake venom is not all bad. There are many instances where venom can be developed into drugs used, for example, in the treatment of hypertension, heart failure and diabetic kidney disease. The drug Aggrastat, which is used for chest pain, was developed using a peptide from an African viper.

Herbal healing in Africa

Historically plants have always been a major source of drugs. A quarter of all new medicinal products registered worldwide, come from plants or other natural resources. This impressive potential has its origins in the fact that plants have evolved to contain substances that prevent them being eaten or attacked by diseases. These biologically active defence compounds can sometimes be useful for developing new drugs. And Africa's poor use nature as their medicine cabinet.

"In Africa where much of the population can't afford medicine, there is a tradition of seeking out healers and alternative therapists, before turning to conventional medicine. Eighty percent visit the healer before they go to the hospital. Traditional herbal medicine is based on centuries of traditions and achievement, so the local shamans and medicine men are often a good place to start when you are looking for active substances with real pharmaceutical effects," says Marianne Molander.

### Contact information:

PhD Student
Marianne Molander
Department of Drug Design and Pharmacology
Faculty of Health and Medical Sciences
Mobile: +45 61 18 56 33
E-mail: mmo@sund.ku.dk

Communications Officer
Stine Rasmussen
University of Copenhagen
Mobile: +45 24 34 03 22
E-mail: stine.rasmussen@sund.ku.dk