(Press-News.org) DENVER – The International Association for the Study of Lung Cancer (IASLC), the American Thoracic Society (ATS), and the European Respiratory Society (ERS), have proposed a new sub-classification of lung adenocarcinomas. A growing number of publications from Australia, Germany and South America have validated the new sub-classification. However, there are only few reports of this type of validation for the Asian population. A new study published in the January 2013 issue of the International Association for the Study of Lung Cancer's (IASLC) Journal of Thoracic Oncology, concludes the new IASLC/ATS/ERS classification identifies histologic subtypes of lung adenocarcinomas with prognostic value among Japanese patients.
Researchers looked at patients with lung adenocarcinoma who underwent pul¬monary resection between January 2001 and December 2009 at Kyoto University Hospital, Japan. The histological investigation included 440 lung adenocarcinomas, which met the 2004 WHO crite¬ria for primary lung adenocarcinoma. Tumor staging was performed according to the 7th edition of the tumor, node, metastasis classification of the International Union Against Cancer.
Researchers concluded that the new classification identifies histologic subtypes of lung adenocarcinomas with prognostic value among Japanese patients. Moreover, they say, "EGFR mutations were significantly identified in AIS/MIA/Lepidic/Pap subtypes. Conversely, KRAS mutations were frequently identified in mucinous sub¬types."
On the basis of these findings, they conclude, "that histologic subtyping and molecular testing for EGFR and KRAS muta¬tions are helpful for predicting prognosis among patients with resectable lung cancer and may be helpful in selecting patients who require adjuvant chemotherapy."
The lead author of this work is Dr. Akihiko Yoshizawa. Co-authors include IASLC members Dr. Masashi Kobayashi, Dr. William Travis and Dr. Hiroshi Date.
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About the IASLC:
The International Association for the Study of Lung Cancer (IASLC) is the only global organization dedicated to the study of lung cancer. Founded in 1974, the association's membership includes more than 3,500 lung cancer specialists in 80 countries. To learn more about IASLC please visit www.iaslc.org.
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DENVER – Chronic obstructive pulmonary disease (COPD) and lung cancer are two of the most important smoking-related diseases worldwide, with a huge combined mortality bur¬den. Many consider the presence of COPD itself to be an independent risk factor for lung cancer. Others argue that smoking contributes to both COPD and lung cancer. A recent study published in the January 2013 issue of the International Association for the Study of Lung Cancer's (IASLC) Journal of Thoracic Oncology, concludes that COPD is not an independent risk factor for lung cancer.
Researchers from ...
DENVER – Favorable results have led to crizotinib gaining approval for the treatment of advanced stage ALK-positive non-small cell lung cancer (NSCLC) in Japan, the United States, Canada, and several other countries in Europe and Asia. Now, the identification of an effective therapy for ALK-positive NSCLC places great emphasis on rapid, accurate, and cost-effective way to find patients with this subtype of lung cancer. A recent study published in the January 2013 issue of the International Association for the Study of Lung Cancer's (IASLC) Journal of Thoracic Oncology, ...
Today at the International Osteoporosis Foundation's Asia-Pacific Osteoporosis Meeting, researchers from the National Institute of Nutrition in Hanoi presented a new research study that showed the benefits of educational intervention in increasing calcium intake and retarding bone loss in postmenopausal women.
Researchers carried out a controlled trial in the Red River Delta in Vietnam involving a total of 140 women. The women, aged 55 years, had been postmenopausal for at least 5 years, and had low dietary calcium intake (less than 400 mg/day). An intervention group ...
Cambridge, UK (December 15, 2012)--Piraye Yurttas Beim, PhD, Founder and CEO of the biotech firm Celmatix Inc., and a leading international expert in the genetics of female infertility, presented A Report from the Front Lines of the Personalized Reproductive Medicine Revolution at the Futures in Reproduction Conference at the Churchill College, Cambridge, a two- day meeting celebrating the spirit of inquiry personified by Nobel Prize winner Professor Sir Robert Edwards.
In the not so distant future, Dr. Beim predicts things will be very different for women who struggle ...
Executive function (EF), frequently associated with the frontal lobes, guides complex behavior such as planning, decision-making, and response control. EF impairment due to alcohol dependence (AD) has been linked to alcohol's toxic effects on the frontal lobes. A study of EF in a group of adult offspring of AD individuals has found that increased impulsiveness and decreased EF may comprise an inherited trait that signifies greater risk for developing AD.
Results will be published in a special online issue of Alcoholism: Clinical & Experimental Research and are currently ...
Prior research has shown that sensitivity to the stimulating effects of alcohol and other drugs is a risk marker for heavy or problematic use of those substances. Prior research has also shown that the personality trait of negative emotionality can have an effect on substance use. A new study examining how the response to an amphetamine interacts with negative emotionality to influence alcohol and drug use has found that a high level of negative emotionality may lead to problem drinking when it occurs together with sensitivity to a drug-based reward.
Results will be ...
While exposure to alcohol marketing is prevalent, and associated with both initiation and progression of alcohol use in underage youth, exactly how it works is not well understood. A new study of alcohol-specific cognitions – whether someone thinks of him/herself as a drinker or having a favorite brand of alcohol – has found that drinker identity and brand allegiance are indeed factors linking alcohol marketing and problematic drinking among experimental underage drinkers.
Results will be published in a special online issue of Alcoholism: Clinical & Experimental Research ...
Contact: Emmanuel Kuntsche
ekuntsche@addictionsuisse.ch
41-213-212-952
Addiction Switzerland
Contact: Allaman Allamani
allamana@gmail.com
39-55-462-4331 (Italy)
Regional Health Agency, Tuscany
Alcoholism: Clinical & Experimental Research
Early drunkenness may be riskier than an early age at first drink for problem behaviors
Many researchers and clinicians believe that an early age at first drink (AFD) can lead to alcohol problems.
A new study challenges that belief by examining linkages between AFD and problem behaviors.
Findings show that early ...
Contact: Jan W. Wijnia
j.wijnia@zorggroeprijnmond.nl
31-102-931-555
Slingedael Korsakoff Center
Contact: Frits A. J. Muskiet
f.a.j.muskiet@umcg.nl
31-50-361-2733 or 9228
University Medical Center Groningen
Alcoholism: Clinical & Experimental Research
Vitamin D deficiency may contribute to alcohol-related muscular weakness
Myopathy refers to a disease characterized by muscular weakness and wasting.
Vitamin D deficiency is a well-recognized cause of myopathy, and excessive drinking is often associated with low or subnormal levels of vitamin D.
A ...
Chronic use of alcohol and marijuana during youth is associated with poorer neural structure, function, and metabolism, as well as worsened neurocognitive abilities into later adolescence and adulthood. This may be due to biological and psychosocial transitions occurring during adolescence that impart increased vulnerability to neurotoxic influences. A study of longitudinal changes in fiber tract integrity associated with adolescent alcohol and marijuana use during 1.5 years supports previous findings of reduced white-matter integrity in these youth.
Results will be ...
