(Press-News.org) Putnam Valley, NY. (Dec. 20, 2012) – A team of researchers from three medical institutions in Guangzhou, China, have found that iron oxide nanoparticles (INOPS) are a useful contrast agent for in vivo magnetic resonance tracking of transplanted human endothelial cells. However, the impact of INOPS on the cells varies with a number of factors including the INOPS load. They found that the percentage of iron-labeled cells was significantly lower after 48 hours post-transplantation than at 24 hours post-transplantation. They also found that high INOPS concentration can affect cell activity. High INOPS concentration can induce cell death (apoptosis).
Their study is published in the current issue of Cell Transplantation (21:9), now freely available on-line at http://www.ingentaconnect.com/content/cog/ct/.
"A good MRI contrast agent must possess a number of features," said study co-author Dr. Wen-Li Chen, at South China Normal University's MOE Key Laboratory of Laser Life Science. "Those features are: low toxicity and good stabilization, high sensitivity, good solubility and the ability to remain in the target cell for a long time. In our study, we found that INOPS are sensitive and can perturb the static magnetic field and provide a string change in MR signals."
The researchers found that the INOPS could be taken up by the cell rather than adhering to the exterior of the cell membrane. However, they also found that a proportional relationship might exist between the number of labeled cells and signal intensity.
"For the first time, we identified that autophagy death could take place at high INOPS loading concentrations," said the researchers.
They also discovered that an increased incubation time, from 24 to 48 hours, did not increase cellular uptake of INOPS and that the percentage of labeled cells declined after 24 hours to be significantly lower by 48 hours.
"It is possible that when the intracellular iron becomes saturated, the particles may start to be expelled out of cells," they concluded. "Thus, the determination of optimal loading concentration is an important step in maintaining the quality of cell labeling and cell activity."
###
Contact: Dr. Wen-Li Chen, MOE Key Laboratory of Laser Life Science, South China Normal University, Guangzhou, China
Tel. +86-20-85224007
Email: chenwl@scnu.ch
Citation: Yang, F-Y.; Yu, M-X.; Zhou, Q.; Chen, W-L.; Gao, P.; Huang, Z. Effects of Iron Oxide Nanoparticle Labeling on Human Endothelial Cells. Cell Transplant. 21(9):1805-1820; 2012.
The Coeditors-in-chief for CELL TRANSPLANTATION are at the Diabetes Research Institute, University of Miami Miller School of Medicine and Center for Neuropsychiatry, China Medical University Hospital, TaiChung, Taiwan. Contact, Camillo Ricordi, MD at ricordi@miami.edu or Shinn-Zong Lin, MD, PhD at shinnzong@yahoo.com.tw or David Eve, PhD at celltransplantation@gmail.com
News release by Florida Science Communications www.sciencescribe.net
Study reports iron oxide nanoparticles effective for labeling human endothelial cells
Loading cells too heavily with INOPS can cause cell death
2012-12-21
ELSE PRESS RELEASES FROM THIS DATE:
Doing the math for how songbirds learn to sing
2012-12-21
Scientists studying how songbirds stay on key have developed a statistical explanation for why some things are harder for the brain to learn than others.
"We've built the first mathematical model that uses a bird's previous sensorimotor experience to predict its ability to learn," says Emory biologist Samuel Sober. "We hope it will help us understand the math of learning in other species, including humans."
Sober conducted the research with physiologist Michael Brainard of the University of California, San Francisco.
Their results, showing that adult birds correct ...
Young scientist helps identify cause of widespread eye disease
2012-12-21
Branch retinal vein occlusion – blockage of the blood vessels that channel blood from the retina – is a common eye disease. A type of blood clot in the eye, the disease causes reduced vision, and people with the disease also typically have an increased risk of hypertension, diabetes and other serious conditions. A young scientist from the University of Copenhagen has made a significant contribution to finding the cause of the disease.
Mette Bertelsen and her colleagues photographically verified the diagnosis of branch retinal vein occlusion in 1168 people.
A team of ...
NJ Association of Verismo Opera to Hold Auditions for Boys to Perform in Gianni Schicchi
2012-12-21
The NJ Association of Verismo Opera is known for developing the stars of tomorrow. Artistic Director Lucine Amara announces boys, nine to eleven years of age, with a soprano voice are invited to audition for the role Gherardino in the grand, professional opera company's production of Giacomo Puccini's Gianni Schicchi that will be performed on Sunday, April 21 at the Bergen Performing Arts Center (bergenPAC) in Englewood, New Jersey.
Open auditions will be held on January 7, 2013 from 4-7 p.m. at the bergenPAC in the Cabaret Room, 30 North Van Brunt Street. The application ...
Powerstone Property Management Reports Double Digit Growth in 2012
2012-12-21
PowerStone Property Management Inc. a full service Orange County, California based property management firm, today announced that in 2012 it has added twenty-two new Home Owner Associations to its client roster representing a 25% growth jump from the previous year. Its professional staff has also increased by 12% over last year with the addition of 5 new employees. Client additions include a mix of new condominium, master planned, single family, and commercial properties.
"Out of the 22 or so associations we gained this year, most came in the 3rd and 4th quarters." ...
MediPurpose Donates babyLance Heelsticks to Matthew: 25 Ministries
2012-12-21
MediPurpose(tm), a master distributor and manufacturer of medical products, today announced that it donated 1900 cases of babyLance(tm) infant heelsticks to international humanitarian aid and disaster relief organization Matthew 25: Ministries.
Working closely with U.S. hospitals, corporations, businesses and individuals, Matthew 25: Ministries has shipped an estimated 115 million pounds of donated humanitarian supplies to the needy in the United States of America and impoverished countries in Central and South America, the Caribbean, the Balkans and Africa.
"MediPurpose's ...
Metropolis Iron Releases Learn More Section on Website
2012-12-21
Metropolis Iron, a fabricator of custom drapery hardware, address plaques and cornices, has released a new section to their website targeted to the needs of designers and buyers of custom fabricated metal home decor items. The new Metropolis Iron Learning Center features tidbits on Metropolis' line of products and general items related to drapery medallions and hardware.
The new Learn More feature can be found at http://metroiron.net/metropolis-iron-learning-center/ on their website under the "About Metropolis Iron" tab at the top of the Home Page. With new ...
DRS and Associates Named Agency of Record for Public Relations, Advertising and Marketing by Sonneman.
2012-12-21
DRS and Associates, a full-service, marketing and public relations agency renowned for guiding and branding major home design and architectural brands and building materials, has been named agency of record for Sonneman - A Way of Light. DRS will oversee the seamless integration of Sonneman - A Way of Light's public relations, advertising, digital and social media campaigns. Work on the account begins immediately.
"In choosing a partner for our brand," said Robert Sonneman, founder and CEO of Sonneman - A Way of Light, "we wanted a firm with strong ties ...
Nutrilys Del Mar Offers Exclusive Christmas Sweepstakes
2012-12-21
Nutrilys Del Mar, a leading marine supplements company based in San Diego, launched its Secret Santa Sweepstakes this week. The Nutrilys Del Mar Facebook contest runs through the 24th and requires no purchase in order to participate.
"Nutrilys Del Mar is really feeling the Christmas spirit this year," said Nutrilys Del Mar founder and CEO, Thierry Lerond. "We wanted to give the free gift of health for the holidays where people could boost their immune system, increase their energy, and get through the hustle and bustle of the holiday season. And our supplements ...
Sunflower Systems Supports Community Lodgings This Holiday Season
2012-12-21
On Saturday, December 15, 2012, Sunflower Systems Solutions Team members, spouses, and friends took time out of their busy holiday schedule to give back to the community. Our volunteers gathered to provide food, service and entertainment at Community Lodgings' annual Christmas Party. Community Lodgings (CLI), located in Alexandria, opens "doors of opportunity" for homeless and disadvantaged families with affordable housing, training, and support.
"All of us here at Community Lodgings are extremely grateful to Sunflower Systems and your entire staff for ...
GammaTech Rugged, Convertible U12Ci Notebook: Ideal for Critical Enterprise Applications
2012-12-21
GammaTech Computer Corp., a major international manufacturer and supplier of innovative notebook and tablet computers, has the perfect solution for critical enterprise applications calling for a rugged computer: its convertible U12Ci notebook. Featuring the advanced Intel Pentium processor, the unit is designed to meet the many varied needs encountered daily by companies of all sizes and in scores of industries.
"Our Durabook U12Ci rugged tablet starts at under $1,000 and is ready to ship, which makes it a perfect last-minute 2012 company IT purchase," stated ...
LAST 30 PRESS RELEASES:
Thirty-year mystery of dissonance in the “ringing” of black holes explained
Less intensive works best for agricultural soil
Arctic rivers project receives “national champion” designation from frontiers foundation
Computational biology paves the way for new ALS tests
Study offers new hope for babies born with opioid withdrawal syndrome
UT, Volkswagen Group of America celebrate research partnership
New Medicare program could dramatically improve affordability for cancer drugs – if patients enroll
Are ‘zombie’ skin cells harmful or helpful? The answer may be in their shapes
University of Cincinnati Cancer Center presents research at AACR 2025
Head and neck, breast, lung and survivorship studies headline Dana-Farber research at AACR Annual Meeting 2025
AACR: Researchers share promising results from MD Anderson clinical trials
New research explains why our waistlines expand in middle age
Advancements in muon detection: Taishan Antineutrino Observatory's innovative top veto tracker
Chips off the old block
Microvascular decompression combined with nerve combing for atypical trigeminal neuralgia
Cutting the complexity from digital carpentry
Lung immune cell type “quietly” controls inflammation in COVID-19
Fiscal impact of expanded Medicare coverage for GLP-1 receptor agonists to treat obesity
State and sociodemographic trends in US cigarette smoking with future projections
Young adults drive historic decline in smoking
NFCR congratulates Dr. Robert C. Bast, Jr. on receiving the AACR-Daniel D. Von Hoff Award for Outstanding Contributions to Education and Training in Cancer Research
Chimpanzee stem cells offer new insights into early embryonic development
This injected protein-like polymer helps tissues heal after a heart attack
FlexTech inaugural issue launches, pioneering interdisciplinary innovation in flexible technology
In Down syndrome mice, 40Hz light and sound improve cognition, neurogenesis, connectivity
Methyl eugenol: potential to inhibit oxidative stress, address related diseases, and its toxicological effects
A vascularized multilayer chip reveals shear stress-induced angiogenesis in diverse fluid conditions
AI helps unravel a cause of Alzheimer's disease and identify a therapeutic candidate
Coalition of Autism Scientists critiques US Department of Health and Human Services Autism Research Initiative
Structure dictates effectiveness, safety in nanomedicine
[Press-News.org] Study reports iron oxide nanoparticles effective for labeling human endothelial cellsLoading cells too heavily with INOPS can cause cell death