PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Study of how eye cells become damaged could help prevent blindness

Study of how eye cells become damaged could help prevent blindness
2013-01-22
(Press-News.org) Light-sensing cells in the eye rely on their outer segment to convert light into neural signals that allow us to see. But because of its unique cylindrical shape, the outer segment is prone to breakage, which can cause blindness in humans. A study published by Cell Press on January 22nd in the Biophysical Journal provides new insight into the mechanical properties that cause the outer segment to snap under pressure. The new experimental and theoretical findings help to explain the origin of severe eye diseases and could lead to new ways of preventing blindness.

VIDEO: This video explains how mutant opsin aggregates in rod photoreceptor outer segments.
Click here for more information.

"To our knowledge, this is the first theory that explains how the structural rigidity of the outer segment can make it prone to damage," says senior study author Aphrodite Ahmadi of the State University of New York Cortland. "Our theory represents a significant advance in our understanding of retinal degenerative diseases."

The outer segment of photoreceptors consists of discs packed with a light-sensitive protein called rhodopsin. Discs made at nighttime are different from those produced during the day, generating a banding pattern that was first observed in frogs but is common across species. Mutations that affect photoreceptors often destabilize the outer segment and may damage its discs, leading to cell death, retinal degeneration, and blindness in humans. But until now, it was unclear which structural properties of the outer segment determine its susceptibility to damage.

To address this question, Ahmadi and her team examined tadpole photoreceptors under the microscope while subjecting them to fluid forces. They found that high-density bands packed with a high concentration of rhodopsin were very rigid, which made them more susceptible to breakage than low-density bands consisting of less rhodopsin. Their model confirmed their experimental results and revealed factors that determine the critical force needed to break the outer segment.

VIDEO: This video explains how vision is affected by a bending rod.
Click here for more information.

The findings support the idea that mutations causing rhodopsin to aggregate can destabilize the outer segment, eventually causing blindness. "Further refinement of the model could lead to novel ways to stabilize the outer segment and could delay the onset of blindness," says Ahmadi.



INFORMATION:



Biophysical Journal, Haeri et al.: "Modeling the Flexural Rigidity of Rod Photoreceptors."


[Attachments] See images for this press release:
Study of how eye cells become damaged could help prevent blindness

ELSE PRESS RELEASES FROM THIS DATE:

Controlling spine metastases with tumor 'separation surgery' and high-dose stereotactic radiosurgery

2013-01-22
Charlottesville, VA (January 22, 2013). Researchers from Memorial Sloan-Kettering Cancer Center (New York, NY) have found that tumor "separation surgery" followed by high-dose hypofractionated stereotactic radiosurgery (SRS) or high-dose single-fraction SRS is safe and effective in controlling spinal metastases regardless of the radiosensitivity of the particular tumor type that has invaded the spine. This finding is fleshed out in the article "Local disease control for spinal metastases following 'separation surgery' and adjuvant hypofractionated or high-dose single-fraction ...

Evidence mounts for role of mutated genes in development of schizophrenia

2013-01-22
Johns Hopkins researchers have identified a rare gene mutation in a single family with a high rate of schizophrenia, adding to evidence that abnormal genes play a role in the development of the disease. The researchers, in a report published in the journal Molecular Psychiatry, say that family members with the mutation in the gene Neuronal PAS domain protein 3 (NPAS3) appear at high risk of developing schizophrenia or another debilitating mental illnesses. Normally functioning NPAS3 regulates the development of healthy neurons, especially in a region of the brain known ...

A diffusion trap

A diffusion trap
2013-01-22
KANSAS CITY, MO – Over the past several years, Rong Li, Ph.D., at the Stowers Institute for Medical Research has been making crucial discoveries about the development of cell polarity—the process by which one side of a cell becomes different from the other side. Such polarity is critical for the functioning of the vast majority of cells. The outside surface of skin cells is very different from the surface inside the body, for example, while nerve cells have delicately branching dendrites on one end and axons on the other. Li's lab studies yeast cells, which form a unique ...

Synchrotron infrared unveils a mysterious microbial community

Synchrotron infrared unveils a mysterious microbial community
2013-01-22
In the fall of 2010, Hoi-Ying Holman of the U.S. Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) was approached by an international team researching a mysterious microbial community discovered deep in cold sulfur springs in southern Germany. "They told me what they were doing and said, 'We know what you contributed to the oil-spill research,'" recalls Holman, who heads the Chemical Ecology group in Berkeley Lab's Earth Sciences Division. "They wondered if I could help them determine the biochemistry of their microbe samples." Holman had ...

Immune cells engineered in lab to resist HIV infection, Stanford study shows

2013-01-22
STANFORD, Calif. — Researchers at the Stanford University School of Medicine have found a novel way to engineer key cells of the immune system so they remain resistant to infection with HIV, the virus that causes AIDS. A new study describes the use of a kind of molecular scissors to cut and paste a series of HIV-resistant genes into T cells, specialized immune cells targeted by the AIDS virus. The genome editing was made in a gene that the virus uses to gain entry into the cell. By inactivating a receptor gene and inserting additional anti-HIV genes, the virus was blocked ...

Sex of early birds suggests dinosaur reproductive style

2013-01-22
In a paper published in Nature Communications on January 22, 2013, a team of paleontologists including Dr. Luis Chiappe, Director of the Natural History Museum of Los Angeles County's (NHM) Dinosaur Institute, has discovered a way to determine the sex of an avian dinosaur species. Confuciusornis sanctus, a 125-million-year-old Mesozoic bird, had remarkable differences in plumage — some had long, almost body length ornamental tail feathers, others had none — features that have been interpreted as the earliest example of avian courtship. However, the idea that male Confuciusornis ...

The skin aging regulator

The skin aging regulator
2013-01-22
These mechanisms, described in vivo in mice, engage molecule CD98hc, which is involved in epidermis renewal and could be an indicator of the skin's capacity for regeneration. The results were published in the Journal of Experimental Medicine review. The epidermis, the surface layer of the skin, is mainly composed of keratinocytes cells, which, in humans, are renewed continuously over a 21-day cycle. These cells are located on a membrane made up of components from the extracellular matrix that provides the junction with the dermis, the deep layer of the skin (see diagram). ...

Harmful effects of bisphenol A proved experimentally

2013-01-22
Bisphenol A (BPA) is a chemical compound that is included in the composition of plastics and resins. It is used, for example, in the manufacture of food containers such as bottles and babies' feeding bottles. It is also found in the protective films used inside food and drink cans and on till receipts where it used as a discloser. Significant levels of BPA have also been found in human blood, urine, amniotic fluid and placentas. Recent studies have shown that this industrial component has harmful effects on reproductive ability, development and the metabolism of laboratory ...

Analysis of fracking wastewater yields some surprises

2013-01-22
DURHAM, N.C. -- Hydraulically fractured natural gas wells are producing less wastewater per unit of gas recovered than conventional wells would. But the scale of fracking operations in the Marcellus shale region is so vast that the wastewater it produces threatens to overwhelm the region's wastewater disposal capacity, according to new analysis by researchers at Duke and Kent State universities. Hydraulically fractured natural gas wells in the Marcellus shale region of Pennsylvania produce only about 35 percent as much wastewater per unit of gas recovered as conventional ...

EARTH: The dangers of solar storms

2013-01-22
Alexandria, VA – Throughout history, humanity has steadily increased its dependence upon technology. Although technology has vastly improved the quality of life for billions of people, it has also opened us up to new risks and vulnerabilities. Terrorism and natural disasters might be at the forefront of the minds of policymakers and the U.S. population, but a significant threat lurks over our heads: the sun. A massive solar storm, the size last seen a century and a half ago, could easily leave hundreds of millions of people in the dark for days, weeks or even months. The ...

LAST 30 PRESS RELEASES:

Power plants may emit more pollution during government shutdowns

Increasing pressures for conformity de-skilling and demotivating teachers, study warns

Researchers develop smarter menstrual product with potential for wearable health monitoring

Microwaves for energy-efficient chemical reactions

MXene current collectors could reduce size, improve recyclability of Li-ion batteries

Living near toxic sites linked to aggressive breast cancer

New discovery could open door to male birth control

Wirth elected Fellow of American Physical Society

The Journal of Nuclear Medicine Ahead-of-Print Tip Sheet: October 10, 2025

Destined to melt

Attitudes, not income, drive energy savings at home

The playbook for perfect polaritons

‘Disease in a dish’ study of progressive MS finds critical role for unusual type of brain cell

Solar-powered method lights the way to a ‘de-fossilized’ chemical industry

Screen time linked to lower academic achievement among Ontario elementary students

One-year outcomes after traumatic brain injury and early extracranial surgery in the TRACK-TBI Study

Enduring outcomes of COVID-19 work absences on the US labor market

Affirmative action repeal and racial and ethnic diversity in us medical school admissions

Cancer progression illuminated by new multi-omics tool

Screen time and standardized academic achievement tests in elementary school

GLP-1RA order fills and out-of-pocket costs by race, ethnicity, and indication

Study finds HEPA purifiers alone may not be enough to reduce viral exposure in schools

UVA Health developing way to ID people at risk of dangerous lung scarring even before symptoms appear

How can we know when curing cancer causes myocarditis?

Male infertility in Indian men linked to lifestyle choices and hormonal imbalances

An acoustofluidic device for sample preparation and detection of small extracellular vesicles

The advent of nanotechnology has ushered in a transformative era for oncology, offering unprecedented capabilities for targeted drug delivery and controlled release. This paradigm shift enhances thera

A prototype LED as thin as wallpaper — that glows like the sun

Transnational electoral participation of undocumented Mexican immigrants in the US

A new method to build more energy-efficient memory devices for a sustainable data future

[Press-News.org] Study of how eye cells become damaged could help prevent blindness