Four connected guides to assignment, treatment changes, missing outcomes and the document trail behind the final claim.
4 articles · About 23 minutes in total · Read at your own pace
Follow an invented trial from enrolment to outcome assessment, and learn why a random sequence, concealed allocation and blinding solve different problems.
Read the guide · 6 minA practical guide to intention-to-treat analysis, per-protocol comparisons and the research question hidden behind an estimand.
Read the guide · 5 minWork through a study where the apparent advantage changes under different assumptions about participants whose outcomes were not observed.
Read the guide · 6 minBuild a simple document trail from registration to publication, and learn how to investigate changed outcomes without assuming every amendment is misconduct.
Read the guide · 6 min