Four papers from 9 October connect variant responses, cross-species chromosomes, Cas9 metal dependence and downstream RNA targets. Read the observation beside its denominator, comparison and next useful test.
4 articles · About 24 minutes in total · Read at your own pace
A new single-cell method connects a genetic change with the RNA response around it. Our reading guide examines coverage, comparison labels and the gap between a functional score and a diagnosis.
Read the guide · 6 minCROSS replaces the mouse X chromosome with a rat counterpart. The useful lesson is the difference between keeping DNA intact, regulating it correctly and supporting development.
Read the guide · 6 minSimulations, NMR and biochemical experiments probe a transient regulatory pocket. Our guide keeps a predicted movement, an observed structural response and a cleavage measurement separate.
Read the guide · 6 minDownstream RNA can be a target for antisense oligonucleotides. Our guide examines a potential source of unintended effects and the evidence needed to explain a fall in gene output.
Read the guide · 6 min