During failure of core protein quality control in the nematode C. elegans, a specialized anti-aggregation mechanism relying on pathogen response factors and lysosomal mediated degradation is triggered, promoting tissue-specific resilience to age-dependent protein aggregation and its proteotoxicity. ##### In your coverage, please use this URL to provide access to the freely available paper in PLOS Biology: http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002284 Article Title: A safety mechanism enables tissue-specific resistance to protein aggregation during aging in C. ...

Researchers from the University of Tokyo reveal how the presynaptic Ube3a E3 ligase, a causal factor in Angelman syndrome, eliminates neural chat. The study helps find a better drug target for the Angelman syndrome treatment.  Neurons chat through electrical signals, transmitting information via connection sites between neurons—the synapses. After birth, the number of synapses increases. During childhood, the brain starts to mature and removes many unnecessary synapses. But sometimes, the development of the nervous system goes awry, leading to developmental disorders.  Kotaro ...

Vocal learning complexity, or the ability to imitate sounds, is associated with better problem-solving abilities and larger brains in songbird species, according to a new study. Whether vocal learning complexity was linked with such cognitive phenotypes was previously unknown. The approach used in the study, to study a lineage of birds, serves as a model for testing similar patterns in other vocal learning species. Complex vocal learning – the ability to imitate heard sounds – is a crucial component of human spoken language and has been assumed to be associated with more advanced cognitive abilities. Outside of humans, it has ...

In a Policy Forum, Frank Biermann and colleagues outline demanding – yet realistic – policy reforms to strengthen the governance and implementation of the United Nations’ (UN) ambitious Sustainable Development Goals (SDGs). In 2015, the UN General Assembly agreed on 17 SDGs with 169 targets intended to be achieved by 2030. However, recent research has shown that the political impact of these goals has been limited and has not yet succeeded in reorienting political systems, institutions, or societies ...

Constant exposure of cells to stressing agents, such as pathogens, may disturb an organism’s normal functioning. To fight stress, cells have developed several coping mechanisms, including the inflammatory response.  While inflammation is necessary, too much of it can impair cell and organ function. This is the case with cytokine storms – inflammatory cascades during an infection that can spiral out of control and lead to severe disease and even death, as recently highlighted during the COVID-19 pandemic. In a new paper published in Science, EMBL Grenoble and University ...

Researchers at the Francis Crick Institute, King’s College London and Guy’s and St Thomas’ NHS Foundation Trust have characterised a specialised type of immune cell, which plays a key role in protecting and repairing the cells in the healthy human gut. These protective immune cells are depleted in inflammatory bowel disease (IBD), leaving patients vulnerable to disease progression and severe complications. The findings could lead to better clinical management and treatment options for people living ...

On 18-19 September, the United Nations will convene a major summit to review the state of the Sustainable Development Goals (SDGs)—the 17 global goals that governments agreed upon in 2015 to guide action towards a prosperous and just future. With research showing that the SDGs have since then had little political impact, the UN Summit must pave the way for four major changes in how the SDGs are implemented and governed globally, argues an international group of experts in Science. The article, based on research led by Utrecht University in the Netherlands, brought together a group of scholars with broad expertise in global sustainability governance. “Our ...

Key points:  Protein aggregation in certain tissues is a hallmark of diseases such as neurodegeneration and occurs during ageing, but little is known about how protein quality control mechanisms acting to prevent toxic protein build-up vary on a tissue-by-tissue basis.  Dr Della David and her team have discovered a safety mechanism that acts to lower levels of protein aggregation in C. elegans pharyngeal muscles, but is not active in body-wall muscles.  This new mechanism was identified by comparing protein accumulation in different tissues in ageing nematode worms when ...

Researchers have genetically engineered a marine microorganism to break down plastic in salt water. Specifically, the modified organism can break down polyethylene terephthalate (PET), a plastic used in everything from water bottles to clothing that is a significant contributor to microplastic pollution in oceans. “This is exciting because we need to address plastic pollution in marine environments,” says Nathan Crook, corresponding author of a paper on the work and an assistant professor of chemical and biomolecular engineering ...

CAMBRIDGE, MA -- This block is broken or missing. You may be missing content or you might need to enable the original module. Cancer drugs known as checkpoint blockade inhibitors have proven effective for some cancer patients. These drugs work by taking the brakes off the body’s T cell response, stimulating those immune cells to destroy tumors. Some studies have shown that these drugs work better in patients whose tumors have a very large number of mutated proteins, which scientists believe is because those proteins offer plentiful ...

The growing number of large operators and developers opening coworking premises threatens to end the availability of grassroots community-oriented spaces designed to bring isolated workers together, a new study warns. These coworking communities were originally set up to create serendipitous encounters, knowledge-sharing opportunities, and social capital. But the increasing numbers of big companies running flexible offices means they are less likely to offer services matching these aims. Smaller operators see the incursion by large commercial real estate developers ...

PROVIDENCE, R.I. [Brown University] — The fact that humans and other living organisms can develop and grow from a single cell relies on a process called embryonic development. For healthy tissue to form, cells in the embryo have to organize themselves in the right way in the right place at the right time. When this process doesn’t go right, it can result in birth defects, impaired tissue regeneration or cancer. All of which makes understanding how different cell types organize into a complex tissue ...

Energy system models fail to accurately represent energy storage and might recommend decarbonization strategies that make electric grids less reliable. Policy makers and utilities need robust energy system models to determine the best strategies to decarbonize the world’s electric grids. But most existing models were designed for grids operating more than a decade ago. Today’s grids are much different. New technologies such as solar power and grid energy storage are being rapidly deployed. To accommodate these and other technologies, utilities must run grids in completely new ways. Improvements are needed in energy system ...

Justifying policies through unsubstantiated or slightly invalid arguments can have a significantly negative effect on the public opinion of politicians, according to new research from City, University of London. With increasing scrutiny on global government policies in a ‘post-truth’ era, and in the aftermath of the Covid-19 pandemic that polarised international responses and reactions to the virus, an increased focus has been placed on policymakers to justify their actions and validate reasons for taking decisions. Short of lying, this can often politicians “stretching arguments” – making invalid claims that are difficult to both prove and disprove. The study, ...

The Aegis Consortium, an initiative of the University of Arizona Health Sciences, awarded approximately $650,000 in seed funding to eight pilot research projects in the areas of pandemic control, prediction or preparedness; post-acute effects of pandemics on individuals and societies; and the resilience of built and natural environments. “As we explore the challenges of pandemics such as COVID-19, we will continue to expand our investigative reach with domestic and international research teams to provide a range ...

Under the leadership of UNIST Education Innovation Task Force, a comprehensive guidebook titled ‘A Guide to the Use of Generatvie AI‘ was released on July 28, 2023. This guidebook presents alternative approaches to utilize generative AI, like ChatGPT more efficiently rather than simply prohibiting their use. With a focus on teachers, researchers, and students, the 50-page guidebook provides practical examples of generative AI utilization. To gain insights into the purpose and development ...

Cells are capable of translating mechanical changes into biological responses. This process is known as mechanotransduction and plays a fundamental role in the progression of solid tumors, such as breast cancer. It is well-established that a common mechanical alteration in cancer progression involves tissue hardening. This stiffness is precisely what is detected during self-examinations or breast palpations for potential tumor detection. The stiffness of breast tissue triggers a chain reaction, inducing tension within cells and distorting their nuclei. Ultimately, this nuclear deformation activates genes responsible for controlling cell proliferation, which are closely associated ...

September 14, 2023 — More than 90% of the active members of the National Association of Neonatal Nurses (NANN) believe the organization should pursue racial equity work, and many have specific suggestions for a strategic plan. This feedback comes from the survey results the association released this month in its journal, Advances in Neonatal Care. The journal is published in the Lippincott portfolio by Wolters Kluwer.  "Neonatal care has advanced significantly in recent years, yet ...

The rate at which the universe is expanding, known as the Hubble constant, is one of the fundamental parameters for understanding the evolution and ultimate fate of the cosmos. However, a persistent difference called the “Hubble Tension” is seen between the value of the constant measured with a wide range of independent distance indicators and its value predicted from the big bang afterglow. NASA’s James Webb Space Telescope provides new capabilities to scrutinize and refine some of the strongest observational evidence for this tension. Nobel Laureate Adam Riess from the Johns Hopkins University and ...

PHILADELPHIA – CAR T cell therapy pioneer Carl June, MD, the Richard W. Vague Professor in Immunotherapy in the Perelman School of Medicine at the University of Pennsylvania and director of the Center for Cellular Immunotherapies (CCI) at Penn Medicine’s Abramson Cancer Center, has been named a winner of the 2024 Breakthrough Prize in Life Sciences for the development of chimeric antigen receptor (CAR) T cell immunotherapy, a revolutionary cancer treatment approach in which each patient’s T cells are modified to target and kill their cancer cells. The invention sparked a new path in cancer care, harnessing the power of patients’ own immune systems, a once-elusive ...

One quarter of food consumed in the EU-27 originates from outside the region, highlighting the vulnerability of the EU’s food system.  New research coordinated by Global Footprint Network’s sustainability scientists in collaboration with food system experts published the article “EU-27 Ecological Footprint was primarily driven by food consumption and exceeded regional biocapacity from 2004 to 2014” today in Nature Food. The way food is provided to and consumed by Europeans represents ...

UNIVERSITY PARK, Pa. — Rivers are warming and losing oxygen faster than oceans, according to a Penn State-led study published today (Sept. 14) in the journal Nature Climate Change. The study shows that of nearly 800 rivers, warming occurred in 87% and oxygen loss occurred in 70%. The study also projects that within the next 70 years, river systems, especially in the American South, are likely to experience periods with such low levels of oxygen that the rivers could “induce acute death” for certain species of fish and threaten aquatic diversity at large. “This is a wake-up call,” ...

A model to map energy demand down to street level shows cooling demand in the capital grew by 5% per year between 1980 and 2022 as summers heat up. The Demand.ninja model, created by researchers at Imperial College London and TU Delft, was designed to show how the weather influences hourly energy consumption in buildings. It can also account for changes in demand as the climate changes, including the increase in cooling demand in the summer as heatwaves become more common and more intense. Countries ...

Researchers have discovered a new way to target and kill cancer cells in hard-to-treat brain tumours using electrically charged molecules to trigger self-destruction, that could be developed into a spray treatment used during surgery. A multidisciplinary team of researchers from the University of Nottingham, led by the School of Pharmacy found a new way to harness the extraordinary capabilities of bio-nanoantennae—gold nanoparticles intricately coated with specialised redox active molecules to induce programmed cell death, or apoptosis, in cancer cells on electrical stimulation. The research ...

About The Study: The findings of this study of 805,000 patients ages 18 or older suggest that receipt of physical therapy (PT) after presentation for dizziness was associated with a reduction in fall risk during the subsequent 12 months; thus, timely PT referral for dizziness may be beneficial for these patients. Future research, ideally with a clinical trial design, is needed to explore the independent impact of PT on subsequent falls for adults with dizziness.  Authors: Meredith E. Adams, M.D., M.S., of ...