As conceived by Charles Darwin in the 1800s, evolution is a slow, gradual process during which species adaptations are inherited incrementally over generations. However, today biologists can see how evolutionary changes unfold on much more accelerated timescales. Rather than the evocative plants and animals of the Galapagos Islands that Darwin studied in forming his theory of evolution, Postdoctoral Scholar Joshua Borin and Associate Professor Justin Meyer of UC San Diego’s School of Biological Sciences are documenting rapid evolutionary processes in simple laboratory flasks. Borin ...

Although the group’s work has been freely available since its inception in March 2020, the COVID Moonshot Consortium is finally formally reporting their results. The COVID Moonshot – an open-science, crowdsourced, and patent-free drug discovery campaign targeting the SARS-CoV-2 virus – has yielded a wealth of data on the virus’s main protease, including insights that could pave the way for the development of new and better therapeutics. “The lead therapeutics described by [these researchers] may not be ready in time to affect the current pandemic, considering the timelines and challenges of drug approval,” write Brian Shoichet and Charles ...

Setting out to improve a technology that usually requires bulky, bench-top equipment, Quishi Guo and colleagues have shrunk a mode-locked laser (MLL) to the size of an optical chip with an integrated nanophotonic platform. The results show promise for developing ultrafast nanophotonic systems for a wide range of applications. Mode-locked lasers (MLLs) can produce coherent ultrashort pulses of light at extremely fast speeds – on the order of picoseconds and femtoseconds. These devices have enabled numerous technologies in photonics, including extreme nonlinear optics, two-photon microscopy, ...

Drawing on 30 years of data, researchers show that the number of homes within wildfire perimeters in the U.S. has doubled since the 1990s. This increasing risk is driven by both an increase in wildfires and the expansion of new homes into wildfire-prone areas, especially in the wildland-urban interface. Wildfire risks to homes are increasing, particularly in the wildland-urban interface (WUI), where houses and wildland vegetation are in close proximity. Over the last 12 years, more than 55,000 homes in the U.S. have been lost to wildfires due to rapid increases ...

Two studies highlight new glass- and ceramic-based passive radiative cooling materials. Unlike passive radiative cooling approaches that rely on polymers, these hard materials are more durable and versatile, making them more attractive for a wide range of outdoor passive cooling applications, including those that could help reduce the need for air conditioning. The energy demand for cooling continues to rise, particularly in regions rapidly warming due to climate change. To make matters worse, the growing carbon footprint of cooling systems further contributes to global warming, exacerbating the need for cooling solutions. Passive radiative cooling (PRC) materials, which ...

UCLA researchers have described a previously unknown step in the complex process by which dietary cholesterol is processed in the intestines before being released into the bloodstream – potentially revealing a new pathway to target in cholesterol treatment. Although an existing drug and statins impact part of the process, an experimental drug being studied in UCLA research labs appears to specifically target the newfound pathway, possibly adding a new approach to the cholesterol management toolbox. “Our results show that certain proteins in the Aster family play a critical role in moving cholesterol through the absorption and uptake process,” said ...

Desert birds lay larger eggs when they have more helpers to feed their chicks, new research shows. White-browed sparrow weavers live in family groups in which only a dominant pair breeds and their grown-up offspring, particularly females, help to feed nestlings. The study, by researchers at the University of Exeter, found that mothers increased the size of their eggs when they had more female helpers on hand. The number of male helpers did not affect egg size, probably because male helpers feed chicks at substantially lower rates than female helpers. “We don’t yet fully understand why helped mothers are laying heavier ...

People are beginning to reconsider their reproductive decisions due to complex concerns about climate change, with many choosing to forego childbearing, or reduce the number of children they have as a result, finds a new study by UCL researchers. The research, published in PLOS Climate, is the first systematic review to explore how and why climate change-related concerns may be impacting reproductive decision-making. The team examined 13 studies, involving 10,788 participants, which were conducted between 2012 and 2022, primarily in Global North countries ...

Lasers are essential tools for observing, detecting, and measuring things in the natural world that we can’t see with the naked eye. But the ability to perform these tasks is often restricted by the need to use expensive and large instruments. In a newly published cover-story paper in the journal Science, researcher Qiushi Guo demonstrates a novel approach for creating high-performance ultrafast lasers on nanophotonic chips. His work centers on miniaturizing mode-lock lasers — a unique laser that emits a train of ultrashort, coherent light pulses in femtosecond intervals, which is an astonishing quadrillionth ...

An international group of 35 scientists is calling out conflicts of interest plaguing global plastic treaty negotiations and that have interfered with timely action on other health and environmental issues. They urge the implementation of strict guidelines to prevent the same problems from affecting the UN’s upcoming Science Policy Panel on chemicals. Their concerns and recommendations are outlined in a featured paper in the journal Environmental Science & Technology. “From Big Tobacco to Big Oil, powerful industries use the same playbook to manufacture doubt and sow misinformation,” said co-author Bethanie ...

The work of the COVID Moonshot Consortium is being published in the prestigious journal Science on 10 November, revealing their discovery of a potent SARS-CoV-2 antiviral lead compound.  It also reflects on the success of its open science approach in launching a patent-free antiviral discovery program to rapidly develop a differentiated lead in response to a pandemic emergency.   Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors ) DOI 10.1126/science.abo7201.    The COVID Moonshot initiative ...

ITHACA, N.Y. -- Synthetic polymers are everywhere in our society – from nylon and polyester clothing to Teflon cookware and epoxy glue. At the molecular level, these polymers’ molecules are made of long chains of monomer building blocks, the complexity of which increases functionality in many such materials. In particular, copolymers, which consist of different types of monomers in the same chain, allow for fine-tuning of the material’s properties, said Peng Chen, the Peter J.W. Debye Professor of Chemistry in the College of Arts and Sciences (A&S). The monomer sequence plays a critical role in a material’s properties, but scientists until ...

Philadelphia, November 9, 2023 – Research and treatment of psychiatric disorders are stymied by a lack of biomarkers – objective biological or physiological markers that can help diagnose, track, predict, and treat diseases. In a new study, researchers use a very large dataset to identify predictive brain imaging-based biomarkers of mental illness in adolescents. The work appears in Biological Psychiatry, published by Elsevier. Traditionally, psychiatric disorders such as depression have been diagnosed based on symptoms according to subjective assessments. The identification of biomarkers to aid in diagnosis and treatment selection would greatly advance treatments. In ...

Many wild animals can carry COVID-19, including those that live among us, such as deer mice, red foxes, white-tailed deer, and more. These species may act as reservoirs, offering new opportunities for the virus to mutate and spill back into people. The omicron variant, for example, is thought to have emerged from mice.  With $3 million in federal grant funding, a new five-year research project will bring together virology, disease ecology, and artificial intelligence to better understand how SARS-CoV-2 (the virus that causes COVID-19) behaves ...

  New research is underway to decipher a fascinating biological puzzle—how some animals can naturally discard more than half of their genetic information during embryonic development.   This radical natural phenomenon has captivated scientists for over 130 years, presenting a tantalizing question in the field of developmental biology and genetics.   Equipped with the latest in genetic engineering tools, the team at The University of Warwick is working to dissect the mechanisms behind this selective genomic editing. By uncovering the processes that allow some nematode worms to abandon up to ...

New URI lab developing adaptive technology, secures National Science Foundation grant Reza Abiri and Yalda Shahriari receive National Science Foundation award totaling $460,000 for work to improve stroke patient rehabilitation Passing by Reza Abiri’s office at the University of Rhode Island, one might suspect him of nursing a serious coffee habit. A colorful collection of various mugs and cups dot his office, and though he is friendly enough to likely welcome any visitors stopping by to chat, the cups serve a larger purpose. Abiri and Yalda Shahriari, professors in ...

HOUSTON ― The University of Texas MD Anderson Cancer Center today announced the launch of its Institute for Data Science in Oncology (IDSO), which integrates the most advanced computational and data science approaches with the institution’s extensive scientific and clinical expertise to significantly improve patient’s lives by transforming cancer care and research. Bringing top data scientists from a variety of fields together with clinicians and cancer scientists, the institute builds on MD Anderson’s culture of collaboration and connectivity to tackle the field’s most pressing needs in new and innovative ways. IDSO’s efforts have been catalyzed by philanthropic ...

The MAF protein interacts with the estrogen receptor, alters its function, and promotes the spread of cancer. The KDM1A enzyme plays a fundamental role in the epigenetic remodelling that facilitates the function of pro-metastatic genes. The work carried out in Dr. Roger Gomis Lab at IRB Barcelona has been published in the journal Nature Cell Biology. Barcelona, 9 November 2023 – Breast cancer is the most common form of cancer among women, with more than 2 million new cases diagnosed each year. In cases where the tumour remains localised in the breast, survival rates are remarkably high, ...

New research: Fivefold increase in the melting of Greenland's glaciers over the last 20 years In the largest survey of its kind ever conducted, using both satellite imagery and old aerial photos from the Danish National Archives, researchers from the University of Copenhagen firmly establish that Greenland’s glaciers are melting at an unprecedented pace. Melting has increased fivefold in the past 20 years. The study eliminates any lingering doubts about the impact of climate change on Greenland's more than 20,000 glaciers. Based on the most comprehensive monitoring ...

A drug currently in clinical trials as a cancer therapy can also stimulate pancreatic beta cells to secrete insulin, revealing a previously unknown mechanism for insulin regulation in type 2 diabetes, according to a new study by Weill Cornell Medicine investigators. The preclinical discovery, reported Nov. 9 in Nature Chemical Biology, provides a new chemical tool for probing the biology of diabetes, and could point the way toward better treatments for the disease. “We have known about insulin for a century, but when it comes to the major mechanisms controlling insulin secretion, there ...

A University of Texas at Dallas bioengineer has developed synthetic enzymes that can control the behavior of the signaling protein Vg1, which plays a key role in the development of muscle, bone and blood in vertebrate embryos. The team of researchers is using a new approach, called the Synthetic Processing (SynPro) system, in zebrafish to study how Vg1 is formed. By learning the molecular rules of signal formation in a developing animal, researchers aim to engineer mechanisms — such as giving cells new instructions — that could play a role in treating or preventing disease. Dr. P.C. Dave P. Dingal, assistant professor of bioengineering in the Erik Jonsson ...

Researchers from Tokyo Medical and Dental University (TMDU) report the construction of a synthetic polymer biomaterial that successfully recapitulates the pancreatic adenocarcinoma microenvironment and could be used to identify novel treatment targets Tokyo, Japan – One of the biggest challenges in biomedical research is finding a way to capture the complexity of the human body in laboratory-based techniques, to enable them to be investigated accurately. Now, researchers from Japan report an approach for precisely imitating a key feature of aggressive cancers in the laboratory. In a study published recently in Inflammation and Regeneration, researchers from Tokyo Medical and ...

The 11 young firefighters went through a rigorous training exercise, carrying up to 40 pounds of gear over hilly terrain during a 45-minute training exercise in the California sun. Gloves, helmets, flashlights, goggles, and more weighted them down as they sprinted through the countryside wearing fire-resistant clothing to show they were ready to serve as wildland firefighters.   When the training was over, they immediately went to the medical tent—not to rest and recover but to give samples of their blood, ...

The reactivation of patterns of neuronal activity based on experience is crucial for learning and memory, but these patterns and the associated brain waves vary widely and are difficult to classify. Such events, dubbed ripples, are characteristic of the hippocampus, a brain region responsible for memory. Until now, the most common way to study ripples was using frequency analysis, but a project led by the Spanish National Research Council (CSIC) has proposed a new classification strategy. Using data science tools, a research group from the Instituto Cajal (IC-CSIC) headed by Liset M. de la Prida has managed to figure out the temporal structure of hippocampal ripples. The scientists ...

Francis Crick Institute press release Under strict embargo: 16:00hrs GMT Thursday 9 November 2023 Peer reviewed Experimental study People and animals Reducing vitamin B5 slows breast cancer growth in mice A group of researchers led by the Francis Crick Institute, working with the National Physical Laboratory (NPL) and Imperial College London, have discovered that breast cancer cells expressing a cancer-driving gene heavily rely on vitamin B5 to grow and survive. The researchers are part of Cancer Grand Challenges team Rosetta, funded by Cancer Research UK. In their research published today in Nature Metabolism, the team studied the metabolic effects of one of the major cancer-driving ...